Search results for "SIG"
showing 10 items of 19670 documents
La organización del trabajo por proyectos: La fábrica de la precariedad laboral
2019
The project-based organization, considered as a radical reorganization of work around one or more simultaneous projects, is nowadays widespread in large companies and public administrations. According to the managerial way of thinking, this system would be virtuous: by giving more autonomy to the employees in the act of production and by developing their skills through mobility and interdisciplinarity of work teams, it would be able to arouse their full commitment. This study confirms in some way how this opinion has been imposed, but at the expense of precarious working conditions, increasing the dedication of employees and silencing any form of criticism. The research is based on a review…
The mitogen-activated protein kinase p38 pathway is conserved in metazoans: Cloning and activation of p38 of the SAPK2 subfamily from the sponge Sube…
2000
Our recent data suggest that during auto- and allograft recognition in sponges (Porifera), cytokines are differentially expressed. Since the mitogen-activated protein kinase (MAPK) signal transduction modulates the synthesis and release of cytokines, we intended to identify one key molecule of this pathway. Therefore, a cDNA from the marine sponge Suberites domuncula encoding the MAPK was isolated and analyzed. Its encoded protein is 366 amino acids long (calculated Mr 42 209), has a TGY dual phosphorylation motif in protein kinase subdomain VIII and displays highest overall similarity to the mammalian p38 stress activated protein kinase (SAPK2), one subfamily of MAPKs. The sponge protein w…
Signal Recognition Particle 54 kD Protein (SRP54) from the Marine Sponge Geodia cydonium
2002
In the systematic search for phylogenetically conserved proteins in the simplest and most ancient extant metazoan phylum – Porifera, we have identified and analyzed a cDNA encoding the signal recognition particle 54 kD protein (SRP54) from the marine sponge Geodia cydonium (Demospongiae). The signal recognition particle (SRP) is a universally conserved ribonucleoprotein complex of a very ancient origin, comprising SRP RNA and several proteins (six in mammals). The nucleotide sequence of the sponge cDNA predicts a protein of 499 amino acid residues with a calculated Mr of 55175. G. cydonium SRP54 displays unusually high overall similarity (90 %) with human/mammalian SRP54 proteins, higher th…
Regulation of motility of cells from marine sponges by calcium ions
1996
Sponges are known not to contain muscle and nerve cells. Since sponge cells are characterized by high motility we determined the effect of intracellular calcium ion concentration ([Ca2+]i) on their motility. Addition of the Ca2+ ionophore ionomycin to dissociated cells from the marine sponge Suberites domuncula caused in Ca(2+)-containing artificial seawater (ASW) an increase in motility from 0.2 micron/min (absence of the ionophore) to 3.7 microns/min (presence of ionomycin). When the experiments were performed in Ca(2+)-free medium, no effect of ionomycin could be observed. In parallel experiments the changes of [Ca2+]i using the dye Fura-2 were measured. The experiments revealed that ion…
Search for inelastic scattering of WIMP dark matter in XENON1T
2021
We report the results of a search for the inelastic scattering of weakly interacting massive particles (WIMPs) in the XENON1T dark matter experiment. Scattering off $^{129}$Xe is the most sensitive probe of inelastic WIMP interactions, with a signature of a 39.6 keV de-excitation photon detected simultaneously with the nuclear recoil. Using an exposure of 0.89 tonne-years, we find no evidence of inelastic WIMP scattering with a significance of more than 2$\sigma$. A profile-likelihood ratio analysis is used to set upper limits on the cross-section of WIMP-nucleus interactions. We exclude new parameter space for WIMPs heavier than 100 GeV/c${}^2$, with the strongest upper limit of $3.3 \time…
XENON1T Dark Matter Data Analysis: Signal Reconstruction, Calibration and Event Selection
2019
The XENON1T experiment at the Laboratori Nazionali del Gran Sasso is the most sensitive direct detection experiment for dark matter in the form of weakly interacting particles (WIMPs) with masses above $6\,$GeV/$c^2$ scattering off nuclei. The detector employs a dual-phase time projection chamber with 2.0 metric tons of liquid xenon in the target. A one metric $\mathrm{ton}\times\mathrm{year}$ exposure of science data was collected between October 2016 and February 2018. This article reports on the performance of the detector during this period and describes details of the data analysis that led to the most stringent exclusion limits on various WIMP-nucleon interaction models to date. In pa…
Sodanikäiset eivät vanhene
2022
How to apply privacy by design in osint and big data analytics?
2019
In a world where technology grows exponentially, more information is available to us every day. States and their governments have collected information on their citizens for a long time now. On the other hand, people give out more and more personal information voluntarily through social media. Information available on the Internet is easier to analyze with modern technologies and the original source of information is also easier to track down. Information is available to all of us and that information can be used to investigate personal data, defeat competitors in a corporate world, solve crimes or even win wars. This study analyses open source intelligence (OSINT) and big data analytics (B…
Korkeakoulutuksen eriytyvät työelämätulokset
2018
Tässä väitöskirjassa tarkastellaan korkeakoulutettujen tutkinnollaan saavuttamien työelämätulosten eriytymistä ja eriytymisen yhteyttä koulutusalaan sekä muihin tutkinnon suorittaneiden taustaan liittyviin tekijöihin. Näitä tekijöitä ovat sukupuoli, pohjakoulutus ja ikä. Lisäksi eriytymistä tarkastellaan työantajasektorin (julkinen/yksityinen) mukaan, joka on olennaisesti yhteydessä sekä koulutusalaan että sukupuoleen. Tutkimuksen teoreettisessa kehyksessä korkeakoulututkinto ymmärretään resurssina, joka valmistuneella on hyödynnettävissä työelämään sijoittumisessa, mutta jonka hyödynnettävyys eriytyy henkilöiden muiden ominaisuuksien mukaan. Resurssinäkökulma perustuu signaaliteoriaan, jon…
Zero Waste principu īstenošanas iespējas interjerā
2019
Šajā darbā tiek pētītas zero waste principu implementācijas iespējas interjerā, analizējot literatūru, kas apraksta ilgtspējīgu dizainu un bezatkritumu kustības attīstības virzienus. Pētījumā izvirzīts jautājums par to, kādi nosacījumi jāievēro, projektējot zero waste koncepta veikalu. Darba mērķis sevī ietver zero waste (beziepakojuma) veikala interjera dizaina projekta izstrādi. Darba pirmajā nodaļā tiek aprakstīts, kas ir zero waste, kā tas izpaužas interjerā un ko sevī ietver šī koncepta veikali. Otrajā nodaļā tiek salīdzināti esošie beziepakojuma veikali Latvijā (“Burka”, “Turza”, “Tavs Zeroveikals”, “Neiepakots”, “Zemes Draugs”) un tam seko veikalu salīdzinājums pasaulē, konkrētāk, Ba…