Search results for "SIGNATURES"
showing 10 items of 45 documents
Diagnostic, Prognostic and Therapeutic Value of Gene Signatures
2012
Gene expression studies have revealed diagnostic profiles and upregulation of specific pathways in many solid tumors. Some gene-expression signatures are already used as predictors of relapse in early breast cancer patients. The explosion of new information in gene expression profiling could potentially lead to the development of tailored treatments in many solid tumors. In addition, many studies are ongoing to validate these signatures also in predicting response to hormonal, chemotherapeutic, and targeted agents in breast cancer as well as in other tumors. This book has been carried out with the aim of providing readers a useful and comprehensive resource about the range of applications o…
Effetto della cultivar e del regime colturale sulla risposta spettrale della chioma in Vitis vinifera L.
2008
Lo studio consente di caratterizzare le risposte spettrali all’invaiatura di chioma ed acino di alcune cultivar a bacca nera della piattaforma ampelografica siciliana. La variabilità tra le risposte spettrali delle foglie all’interno della stessa chioma, nonché le variazioni spettrali anche al variare del regime irriguo consentono di effettuare un’analisi comparativa delle cultivar. In questo quadro, le firme spettrali integrano la descrizione ampelografica di chioma e bacche che caratterizza la Vitis Vinifera L.. Infine l’applicazione su un’area pilota di tecniche di classificazione di immagini remote basate sulle caratteristiche spettrali delle cultivar, consente di valutarne le performan…
Genome-wide analyses reveal population structure and identify candidate genes associated with tail fatness in local sheep from a semi-arid area.
2021
Abstract Under a climate change perspective, the genetic make-up of local livestock breeds showing adaptive traits should be explored and preserved as a priority. We used genotype data from the ovine 50 k Illumina BeadChip for assessing breed autozygosity based on runs of homozygosity (ROH) and fine-scale genetic structure and for detecting genomic regions under selection in 63 Tunisian sheep samples. The average genomic inbreeding coefficients based on ROH were estimated at 0.017, 0.021, and 0.024 for Barbarine (BAR, n = 26), Noire de Thibar (NDT, n = 23), and Queue fine de l'Ouest (QFO, n = 14) breeds, respectively. The genomic relationships among individuals based on identity by state (I…
Seven Shades of Grey: A Follow-Up Study on the Molecular Basis of Coat Colour in Indicine Grey Cattle Using Genome-Wide SNP Data
2022
Shades of grey and brown are a dominant component in mammal coat colours, representing a fundamental trait involved in a great number of processes including cryptism, sexual selection and signalling. The genetic mechanisms of the grey colouration in mammals are very complex and controlled by hundreds of genes whose effects and interactions are still largely unclear. In this study, we adopted a robust multi-cohort Fst outlier approach based on pairwise contrasts between seven grey indicine cattle breeds and both taurine and indicine non-grey cattle breeds in order to find genomic regions potentially related to the grey colouration. On the basis of three main drawn settings, built in order to…
Capturing colorectal cancer inter-tumor heterogeneity in patient-derived xenograft (PDX) models
2019
Patient‐derived xenograft (PDX) models have become an important asset in translational cancer research. However, to provide a robust preclinical platform, PDXs need to accommodate the tumor heterogeneity that is observed in patients. Colorectal cancer (CRC) can be stratified into four consensus molecular subtypes (CMS) with distinct biological and clinical features. Surprisingly, using a set of CRC patients, we revealed the partial representation of tumor heterogeneity in PDX models. The epithelial subtypes, the largest subgroups of CRC subtype, were very ineffective in establishing PDXs, indicating the need for further optimization to develop an effective personalized therapeutic approach …
Runs of homozygosity in the Italian goat breeds: impact of management practices in low-input systems
2021
Abstract Background Climate and farming systems, several of which are considered as low-input agricultural systems, vary between goat populations from Northern and Southern Italy and have led to different management practices. These processes have impacted genome shaping in terms of inbreeding and regions under selection and resulted in differences between the northern and southern populations. Both inbreeding and signatures of selection can be pinpointed by the analysis of runs of homozygosity (ROH), which provides useful information to assist the management of this species in different rural areas. Results We analyzed the ROH distribution and inbreeding (FROH) in 902 goats from the Italia…
Mycorrhizal symbiosis changes host nitrogen source use
2021
Abstract Purpose The ecological importance of arbuscular mycorrhizal fungi (AMF) in plant acquisition of inorganic and organic sources of nitrogen (N) is not clear. To improve understanding of the plant N nutrition ecology, we tested the effect of intraspecific competition and AMF in plant N source use in growth and N acquisition. Methods Solidago virgaurea was grown in microcosms in a fully factorial experiment under greenhouse conditions. The factors tested were intraspecific competition between seedlings and adult plants (yes, no), N source (NH4, glycine) and AMF (inoculated with Glomus hoi, not inoculated). Results When grown separately, non-mycorrhizal seedling growth was highest when …
Human Activity Signatures Captured under Different Directions Using SISO and MIMO Radar Systems
2022
In this paper, we highlight and resolve the shortcomings of single-input single-output (SISO) millimeter wave (mm-Wave) radar systems for human activity recognition (HAR). A 2×2 distributed multiple-input multiple-output (MIMO) radar framework is presented to capture human activity signatures under realistic conditions in indoor environments. We propose to distribute the two pairs of collocated transmitter–receiver antennas in order to illuminate the indoor environment from different perspectives. For the proposed MIMO system, we measure the time-variant (TV) radial velocity distribution and TV mean radial velocity to observe the signatures of human activities. We deploy the Anc…
Lowstand carbonates, highstand sandstones?
2003
The sedimentary facies, sediment dynamics and sequence architecture of modern high-energy shelves in the mid and high latitudes are largely governed by wave abrasion processes. Cool-water carbonates may form there, if the influx and/or net accretion of siliciclastics is kept at a minimum. Little dilution of the carbonate produced in situ is generally promoted by a wide "epicontinental" shelf, subdued topography of the adjacent mainland, the predominance of limestone outcrops, and an arid climate. The aforementioned requirements are rarely met, and thus will automatically lead to the formation of mixed siliciclastic-cool-water carbonates. Such an example is found in the Early to Mid-Miocene …
A Combined Multi-Cohort Approach Reveals Novel and Known Genome-Wide Selection Signatures for Wool Traits in Merino and Merino-Derived Sheep Breeds.
2019
Merino sheep represents a valuable genetic resource worldwide. In this study, we investigated selection signatures in Merino (and Merino-derived) sheep breeds using genome-wide SNP data and two different approaches: a classical F-ST-outlier method and an approach based on the analysis of local ancestry in admixed populations. In order to capture the most reliable signals, we adopted a combined, multi-cohort approach. In particular, scenarios involving four Merino breeds (Spanish Merino, Australian Merino, Chinese Merino, and Sopravissana) were tested via the local ancestry approach, while nine pair-wise breed comparisons contrasting the above breeds, as well as the Gentile di Puglia breed, …