Search results for "SIM"

Edificio bioclimatico - Tecniche di simulazione - Tecniche avanzate

2008

Molecular Dynamics Simulations of the Initial Adsorption Stages of Fibrinogen on Mica and Graphite Surfaces.

2015

Fibrinogen, a blood glycoprotein of vertebrates, plays an essential role in blood clotting by polymerizing into fibrin when activated. Upon adsorption on material surfaces, it also contributes to determine their biocompatibility and has been implicated in the onset of thrombosis and inflammation at medical implants. Here we present the first fully atomistic simulations of the initial stages of the adsorption process of fibrinogen on mica and graphite surfaces. The simulations reveal a weak adsorption on mica that allows frequent desorption and reorientation events. This adsorption is driven by electrostatic interactions between the protein and the silicate surface as well as the counterion …

L’ETICA TEOLOGICA E I PRINCIPI DELLA BIOETICA: UNA PROSPETTIVA PROTESTANTE

2012

In un confronto con le tesi di Sergio Rostagno sul rapporto tra etica e protestantesimo, si affronta il più circoscritto rapporto tra bioetica e telogia protestante, muovendo da Lutero e Calvino e alla luce del dibattito odierno, nella direzione di un personalismo laico.

Comparative genomics between two insect symbiotic models: Innate immune system and amino acid biosynthetic pathways of the rice weevil Sitophilus ory…

2019

Los insectos se pueden encontrar en la mayoría de los ecosistemas del planeta y son capaces de aprovechar prácticamente cualquier fuente de alimento. Son el grupo de animales más diverso con un número de especies estimado en cinco millones. Todos los insectos comparten un mismo plan corporal que consiste en tres segmentos (cabeza, tórax y abdomen), tres pares de patas, un par de antenas y ojos compuestos; sin embargo, cada especie tiene partes especializadas acordes con su estilo de vida. A pesar de que los insectos son capaces de aprovechar múltiples fuentes de alimento, en múltiples ocasiones dependen de compañeros microbianos para obtener nutrientes escasos en su dieta. Por ello, la simb…

Protein-protein interaction network querying by a "focus and zoom" approach

2008

We propose an approach to network querying in protein-protein interaction networks based on bipartite graph weighted matching. An algorithm is presented that first “focuses” the potentially relevant portion of the target graph by performing a global alignment of this one with the query graph, and then “zooms” on the actual matching nodes by considering their topological arrangement, hereby obtaining a (possibly) approximated occurrence of the query graph within the target graph. Approximation is related to node insertions, node deletions and edge deletions possibly intervening in the query graph. The technique manages networks of arbitrary topology. Moreover, edge labels are used to represe…

Ultrafast myoglobin structural dynamics observed with an X-ray free-electron laser.

2014

Light absorption can trigger biologically relevant protein conformational changes. The light-induced structural rearrangement at the level of a photoexcited chromophore is known to occur in the femtosecond timescale and is expected to propagate through the protein as a quake-like intramolecular motion. Here we report direct experimental evidence of such ‘proteinquake’ observed in myoglobin through femtosecond X-ray solution scattering measurements performed at the Linac Coherent Light Source X-ray free-electron laser. An ultrafast increase of myoglobin radius of gyration occurs within 1 picosecond and is followed by a delayed protein expansion. As the system approaches equilibrium it underg…

Solving gap metabolites and blocked reactions in genome-scale models: application to the metabolic network of Blattabacterium cuenoti

2013

Abstract Background Metabolic reconstruction is the computational-based process that aims to elucidate the network of metabolites interconnected through reactions catalyzed by activities assigned to one or more genes. Reconstructed models may contain inconsistencies that appear as gap metabolites and blocked reactions. Although automatic methods for solving this problem have been previously developed, there are many situations where manual curation is still needed. Results We introduce a general definition of gap metabolite that allows its detection in a straightforward manner. Moreover, a method for the detection of Unconnected Modules, defined as isolated sets of blocked reactions connect…

Individual repeatability in timing and spatial flexibility of migration routes of trans-Saharan migratory raptors

2015

Satellite-tracking technology has allowed scientists to make a quantum leap in the field of migration ecology. Nowadays, the basic description of migratory routes of many species of birds has been reported. However, the investigation of bird migration at individual level (i.e. repeatability in migratory routes and timing) still remains seldom explored. Here, we investigated repeated migratory trips of a trans-Saharan endangered migratory raptor, the Egyptian Vulture Neophron percnopterus, tracked by GPS satellite telemetry. We compared between- and within-individual variation in migratory routes and timing in order to assess the degree of repeatability (or conversely, the flexibility) in mi…

Kultūraugu savvaļas radinieka Trifolium fragiferum dažādu genotipu reakcija uz rizobiju simbiozi un papildus slāpekli

2022

Šajā pētījumā tika noteikts, kā augiem no astoņām Latvijas zemeņu āboliņa mikropopulācijām inokulācija ar to dabiskajām gumiņbaktērijām, mēslošana ar slāpekļa minerālmēslojumu un abi apstrādes varianti kopā ietekmē augšanu, morfoloģiskos un fizioloģiskos parametrus. Papildus slāpeklis minerālmēslojuma veidā visiem genotipiem veicināja līdzīgu sausās masas pieaugumu, 70 – 92% salīdzinājumā ar asimbiotiskās kontroles augiem, kas netika mēsloti ar papildus N. Inokulācija ar gumiņbaktērijām bez mēslošanas ar papildus slāpekli arī veicināja biomasas pieaugumu, salīdzinājumā ar kontroli, bet šajā apstrādes variantā bija novērojamas izteiktākas atšķirības starp genotipiem. Vairākiem genotipiem ino…

Enchytraeid population dynamics: Resource limitation and size-dependent mortality

2009

Abstract Enchytraeids are regarded as keystone soil organisms in forest ecosystems. Their abundance and biomass fluctuate widely. Predicting the consequences of anthropogenic disturbances requires an understanding of the mechanisms underlying enchytraeid population dynamics. Here I develop a simple model, which predicts that the type of dynamics is controlled by resource input rate. If fungal resource input is a discrete event once a year, an exponential growth phase is followed by starvation and sharp decline of enchytraeid abundance. Model simulations with three different forcing functions were compared to field data. Initial parameter values were obtained from various independent sources…