Search results for "SIM"
showing 10 items of 10139 documents
Conferència: "La dedicació de Sanchis Guarner a la filologia"
2011
Conferència "La dedicació de Sanchis Guarner a la filologia", han intervingut els membres de l'IEC Joan Veny i Brauli Montoya, i també Vicent Simbor, de la Universitat de València, moderats per Antoni Ferrando, membre de l'IEC i professor de la Universitat de València.
Exploration of the Activation Mechanism of the Epigenetic Regulator MLL3: A QM/MM Study
2021
The mixed lineage leukemia 3 or MLL3 is the enzyme in charge of the writing of an epigenetic mark through the methylation of lysine 4 from the N-terminal domain of histone 3 and its deregulation has been related to several cancer lines. An interesting feature of this enzyme comes from its regulation mechanism, which involves its binding to an activating dimer before it can be catalytically functional. Once the trimer is formed, the reaction mechanism proceeds through the deprotonation of the lysine followed by the methyl-transfer reaction. Here we present a detailed exploration of the activation mechanism through a QM/MM approach focusing on both steps of the reaction, aiming to provide new…
Uncertainty quantification on a spatial Markov-chain model for the progression of skin cancer
2019
AbstractA spatial Markov-chain model is formulated for the progression of skin cancer. The model is based on the division of the computational domain into nodal points, that can be in a binary state: either in ‘cancer state’ or in ‘non-cancer state’. The model assigns probabilities for the non-reversible transition from ‘non-cancer’ state to the ‘cancer state’ that depend on the states of the neighbouring nodes. The likelihood of transition further depends on the life burden intensity of the UV-rays that the skin is exposed to. The probabilistic nature of the process and the uncertainty in the input data is assessed by the use of Monte Carlo simulations. A good fit between experiments on mi…
Komētas 67P/Churyumov-Gerasimenko zemas kohēzijas daļiņu elektrostatiskā fragmentācija
2015
Pēc desmit ceļā pavadītiem gadiem un 2.5 gadiem pavadītiem hibernācijas periodā, Eiropas kosmosa aģentūras (angļu: European Space Agency, ESA) izpētes misija Rosetta uz komētu 67P/Churyumov-Gerasimenko ir pilnā datu ieguves režīmā, ar visiem tās 22 zinātniskajiem instrumentiem darbībā, lai izprastu mūsu Saules Sistēmas pirmsākumus. Komētas fizikālais raksturojums parāda, ka tās aptuvenais vidējais blīvums ir ~470 kg/m3 ar relatīvi mīkstu dabu un porozitāti no 70% līdz 80%. Šādām īpašībām apveltītas arī komētas mazākās daļiņas – putekļu graudi, ko parāda Rosettas COSIMA un MIDAS instrumenti - tām ir zema kohēzija tās viegli sadalās. Fizikālie procesi, kas iespējams apraksta šo sadalīšanos ir…
The Philae lander mission and science overview.
2017
The Philae lander accomplished the first soft landing and the first scientific experiments of a human-made spacecraft on the surface of a comet. Planned, expected and unexpected activities and events happened during the descent, the touch-downs, the hopping across and the stay and operations on the surface. The key results were obtained during 12–14 November 2014, at 3 AU from the Sun, during the 63 h long period of the descent and of the first science sequence on the surface. Thereafter, Philae went into hibernation, waking up again in late April 2015 with subsequent communication periods with Earth (via the orbiter), too short to enable new scientific activities. The science return of the…
Sublimation of icy aggregates in the coma of comet 67P/Churyumov–Gerasimenko detected with the OSIRIS cameras on board Rosetta
2016
Beginning in 2014 March, the OSIRIS (Optical, Spectroscopic, and Infrared Remote Imaging System) cameras began capturing images of the nucleus and coma (gas and dust) of comet 67P/Churyumov¿Gerasimenko using both the wide angle camera (WAC) and the narrow angle camera (NAC). The many observations taken since July of 2014 have been used to study the morphology, location, and temporal variation of the comet's dust jets. We analysed the dust monitoring observations shortly after the southern vernal equinox on 2015 May 30 and 31 with the WAC at the heliocentric distance Rh = 1.53 AU, where it is possible to observe that the jet rotates with the nucleus. We found that the decline of brightness a…
Formulations and exact algorithms for the distance-constrained generalized directed rural postman problem
2017
[EN] The generalized directed rural postman problem is an arc routing problem with many interesting real-life applications, such as routing for meter reading. In this application, a vehicle with a receiver travels through a series of neighborhoods. If the vehicle gets closer than a certain distance to a meter, the receiver is able to record the gas, water, or electricity consumption. Therefore, the vehicle does not need to traverse every street, but only a few, to get close enough to each meter. We study an extension of this problem in which a fleet of vehicles is available. Given the characteristics of the mentioned application, the vehicles have no capacities but there is a maximum distan…
El ritual festivo desde la perspectiva teórica de pierre bourdieu: el caso de las fallas de valencia.
2011
El objetivo de la presente contribución es apuntar nuevas perspectivas teóricas que permitan analizar la acción ritual en las sociedades modernas. Concretamente, se pondrá a prueba el concepto de campo, desarrollado por Pierre Bourdieu, como herramienta que nos permita acercarnos a una mejor comprensión de la fiesta de las Fallas. Se argumentará, en primer lugar, la pertinencia de la propuesta a partir de la bibliografía disponible para, a continuación, analizar desde una perspectiva sociohistórica la génesis y estructura del mundo fallero. Seguirán unas reflexiones sobre las relaciones de fuerzas en juego entre los agentes que compiten en dicho campo (ortodoxos y herejes); para concluir, s…
Mujer y representación política institucional en la Comunidad Valenciana. 1977-1995. Diputadas, ministras y cargos institucionales
2014
“Mujer y representación política institucional en la Comunidad Valenciana. 1977-1995. Diputadas, ministras y cargos institucionales” es la primera parte de un trabajo de documentación para un capítulo de “La democracia en la Comunidad Valenciana. Partidos, elites políticas, elecciones y programas políticos”. “Mujer, poder político y democracia paritaria”. Se recoge el papel de la mujer en la vida política de la Comunidad Valenciana en la democracia actual, desde 1977. Es documentación sin elaborar, pero que aporta datos de la presencia de la mujer en las instituciones, partidos y sindicatos. Cuando este completa será una parte de la investigación referida, y de la que ya hay dos publicacion…
Evolution and comparative genomics of di-symbiotic systems in aphids from the Lachninae subfamily and genome reduction in Serratia symbiotica
2016
Ph.D. thesis presented by Alejandro Manzano Marín Director: Prof. Dr. Amparo Latorre Castillo Institution: Universiat de València