Search results for "SIM"

showing 10 items of 10139 documents

A simplified method based on Beerkan infiltration run

2013

A simplified method based on Beerkan infiltration run (SBI) to determine field saturated soil hydraulic conductivity

A simplified method based on Beerkan infiltration run (SBI)soil hydraulic conductivityA simplified method based on Beerkan infiltration run (SBI) soil hydraulic conductivity
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Polyoxypregnanes as safe, potent, and specific ABCB1-inhibitory pro-drugs to overcome multidrug resistance in cancer chemotherapy in vitro and in vivo

2021

Multidrug resistance (MDR) mediated by ATP binding cassette subfamily B member 1 (ABCB1) is significantly hindering effective cancer chemotherapy. However, currently, no ABCB1-inhibitory drugs have been approved to treat MDR cancer clinically, mainly due to the inhibitor specificity, toxicity, and drug interactions. Here, we reported that three polyoxypregnanes (POPs) as the most abundant constituents of Marsdenia tenacissima (M. tenacissima) were novel ABCB1-modulatory pro-drugs, which underwent intestinal microbiota-mediated biotransformation in vivo to generate active metabolites. The metabolites at non-toxic concentrations restored chemosensitivity in ABCB1-overexpressing cancer cells v…

ABCC1 ATP binding cassette subfamily C member 1IC50 half maximal inhibitory concentrationMultidrug resistancePharmacologyNADPH reduced nicotinamide adenine dinucleotide phosphateF bioavailabilitychemistry.chemical_compoundPCR polymerase chain reaction0302 clinical medicineMDR multidrug resistanceECL electrochemiluminescencet1/2 elimination half-lifeLC–MS liquid chromatography coupled with mass spectrometryN.D. not detectedGeneral Pharmacology Toxicology and PharmaceuticsBBB blood–brain barriermedia_commonATF3 activating transcription factor 30303 health sciencesChemistryABC ATP-binding cassetteNMPA National Medical Products AdministrationPXR pregnane X receptorSDS-PAGE sodium dodecyl sulfate-polyacrylamide gel electrophoresisHBSS Hankʹs balanced salt solutionABCB1Combination chemotherapyProdrugMarsdenia tenacissimaCmax peak concentrationPaclitaxelGAPDH glyceraldehyde-3-phosphate dehydrogenase030220 oncology & carcinogenesisBHI brain heart infusionOriginal ArticleAUC0–∞ area under plasma concentration vs. time curveMRT mean residence timeDrugmedia_common.quotation_subjectRM1-950Vd volume of distributionABCB1 ATP binding cassette subfamily B member 1UIC-2 mouse monoclonal ABCB1 antibodyABCG2 ATP binding cassette subfamily G member 2Combination chemotherapyCYP cytochrome P450 isozymePI propidium iodideTEER transepithelial electrical resistance03 medical and health sciencesPBS phosphate buffer salineFBS fetal bovine serumDox doxorubicinIn vivoPOP polyoxypregnanemedicine030304 developmental biologyEVOM epithelial tissue voltohmmeterTmax time for peak concentrationCancerLBE lowest binding energyPE phycoerythrinmedicine.diseaseMultiple drug resistancePolyoxypregnanePapp apparent permeabilityN.A. not applicableCancer cellH&E hematoxylin and eosinMDR1a multidrug resistance protein 1aTherapeutics. PharmacologyqPCR quantitative PCRM. tenacissima Marsdenia tenacissimaCL clearanceSD standard derivationActa Pharmaceutica Sinica B
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Casimir-Lifshitz force out of thermal equilibrium between dielectric gratings

2014

We calculate the Casimir-Lifshitz pressure in a system consisting of two different 1D dielectric lamellar gratings having two different temperatures and immersed in an environment having a third temperature. The calculation of the pressure is based on the knowledge of the scattering operators, deduced using the Fourier Modal Method. The behavior of the pressure is characterized in detail as a function of the three temperatures of the system as well as the geometrical parameters of the two gratings. We show that the interplay between non-equilibrium effects and geometrical periodicity offers a rich scenario for the manipulation of the force. In particular, we find regimes where the force can…

ACS number(s): 12.20.−m42.79.Dj42.50.Ct42.50.Lc[PHYS.MPHY]Physics [physics]/Mathematical Physics [math-ph]Degrees of freedom (physics and chemistry)Non-equilibrium thermodynamicsFOS: Physical sciencesDielectricCasimir Force Out of Thermal equilibrium systems GratingsSettore FIS/03 - Fisica Della Materiasymbols.namesake[PHYS.QPHY]Physics [physics]/Quantum Physics [quant-ph]Lamellar structure[PHYS.COND.CM-SM]Physics [physics]/Condensed Matter [cond-mat]/Statistical Mechanics [cond-mat.stat-mech]PhysicsThermal equilibriumQuantum PhysicsCondensed matter physicsScatteringAtomic and Molecular Physics and OpticsCasimir effectFourier transformClassical mechanicssymbolsQuantum Physics (quant-ph)Physics - OpticsOptics (physics.optics)
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Influence of field crop plantations on microbial characteristics of runoff water: effect on plant growth and soil functioning

2006

International audience

ACTINOMYCETES[SDV] Life Sciences [q-bio][SDE] Environmental SciencesMYCORRHYZAS[SDV]Life Sciences [q-bio][SDE]Environmental SciencesFLUORESCENT PSEUDOMONASRUNOFFRAIN SIMULATIONComputingMilieux_MISCELLANEOUS
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Response of AGATA segmented HPGe detectors to gamma rays up to 15.1MeV

2013

WOS: 000314826000009

AGATA; Gamma-ray spectroscopy; Gamma-ray tracking; HPGe detectors; Pulse-shape and gamma-ray tracking algorithms; Semiconductor detector performance and simulationsNuclear and High Energy PhysicsPulse-shape and gamma-ray tracking algorithmsAstrophysics::High Energy Astrophysical PhenomenaFOS: Physical sciencesSemiconductor detector performance and simulationsTracking (particle physics)01 natural sciencesNuclear physicsGamma-ray tracking0103 physical sciencesGamma spectroscopyddc:530Gamma-ray spectroscopyNuclear Experiment (nucl-ex)010306 general physicsNuclear ExperimentInstrumentationNuclear ExperimentDetectors de radiacióPhysicsSpectrometer010308 nuclear & particles physicsDetectorHPGe detectorsGamma ray81V35Semiconductor detectorAGATAFísica nuclearHpge detectorAGATA
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Calibration of microscopic traffic simulation models for evaluating operation and safety performance at roundabouts

AIMSUN microsimulation roundabout genetic algorithmSSAM surrogate safety measureturbo-roundaboutsingle-lane roundabouts; double-lane roundabouts; turbo-roundabouts; entry capacity; operations; gap- acceptance parameters; Systematic Review; Meta-analysis; capacity uncertainty; AIMSUN microsimulation roundabout genetic algorithm; passenger car equivalent; SSAM surrogate safety measurecapacity uncertaintygap- acceptance parameteroperationsingle-lane roundaboutpassenger car equivalentSettore ICAR/04 - Strade Ferrovie Ed AeroportiMeta-analysiSystematic Reviewdouble-lane roundaboutentry capacity
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Endomicorrize: vantaggi e impiego

2020

AM symbiosis tropical fruit trees biological controlSettore AGR/12 - Patologia VegetaleSimbiosi AM fruttiferi tropicali difesa biologica
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Genetic structure and differentiation from early bronze age in the mediterranean island of sicily: Insights from ancient mitochondrial genomes

2022

Sicily is one of the main islands of the Mediterranean Sea, and it is characterized by a variety of archaeological records, material culture and traditions, reflecting the history of migrations and populations’ interaction since its first colonization, during the Paleolithic. These deep and complex demographic and cultural dynamics should have affected the genomic landscape of Sicily at different levels; however, the relative impact of these migrations on the genomic structure and differentiation within the island remains largely unknown. The available Sicilian modern genetic data gave a picture of the current genetic structure, but the paucity of ancient data did not allow so far to make p…

ANCIENT DNA mitochondrial genomes genetic structure coalescent simulations approximate bayesian computationa DNA Sicily Mediterranean Early Bronze Age MotyaMediterraneanSettore BIO/08 - AntropologiaMotyacoalescent simulationsmitochondrial genomesGeneticsEarly Bronze Agegenetic structureMolecular MedicineANCIENT DNAa DNASicilyGenetics (clinical)approximate bayesian computation
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Monte Carlo simulations of the solid-liquid transition in hard spheres and colloid-polymer mixtures

2010

Monte Carlo simulations at constant pressure are performed to study coexistence and interfacial properties of the liquid-solid transition in hard spheres and in colloid-polymer mixtures. The latter system is described as a one-component Asakura-Oosawa (AO) model where the polymer's degrees of freedom are incorporated via an attractive part in the effective potential for the colloid-colloid interactions. For the considered AO model, the polymer reservoir packing fraction is eta_p^r=0.1 and the colloid-polymer size ratio is q=sigma_p/\sigma=0.15 (with sigma_p and sigma the diameter of polymers and colloids, respectively). Inhomogeneous solid-liquid systems are prepared by placing the solid fc…

ANISOTROPIC SURFACE-TENSIONMaterials scienceMonte Carlo methodDegrees of freedom (physics and chemistry)General Physics and AstronomyThermodynamicsCondensed Matter - Soft Condensed MatterCAPILLARY WAVESAtomic packing factorCOMPUTER-SIMULATIONVAPOR INTERFACE3-DIMENSIONAL ISING-MODELColloidsymbols.namesakePhase (matter)Physical and Theoretical ChemistryCOEXISTING PHASESchemistry.chemical_classificationCondensed Matter - Materials ScienceINTERFACIAL FREE-ENERGYPROFILESHard spheresPolymerCondensed Matter::Soft Condensed MatterchemistryCRYSTAL-MELT INTERFACESBoltzmann constantsymbolsCRYSTALLIZATIONThe Journal of Chemical Physics
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Leon Battista Alberti archeologo

2007

Il Convegno rientra nelle celebrazioni ufficiali per il VI centenario della nascita del grande umanista del Quattrocento italiano. Il contributo, unico nel panorama della critica albertiana, mira a mettere a fuoco le propensioni antiquarie e archeologiche dell'Alberti, inquadrando questi interessi nel vasto panorama della cultura antiquaria del Quattrocento italiano. Ne rivela anche aspetti significativi nel suo concreto operare come architetto e ne ricostruisce le pratiche della ricerca sui monumenti antichi di Roma e di molte altre parti dell'Italia.

ANTIQUARIALEON BATTISTA ALBERTIARCHITETTURAUMANESIMOSTORIA DELL'ARCHEOLOGIASettore L-ANT/07 - Archeologia ClassicaLeon Battista Alberti storia dell'archeologia storia dell'architettura
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