Search results for "SIM"

Integrated care pathways for airway diseases (AIRWAYS-ICPs)

2014

International audience; The objective of Integrated Care Pathways for Airway Diseases (AIRWAYS-ICPs) is to launch a collaboration to develop multi-sectoral care pathways for chronic respiratory diseases in European countries and regions. AIRWAYS-ICPs has strategic relevance to the European Union Health Strategy and will add value to existing public health knowledge by: 1) proposing a common framework of care pathways for chronic respiratory diseases, which will facilitate comparability and trans-national initiatives; 2) informing cost-effective policy development, strengthening in particular those on smoking and environmental exposure; 3) aiding risk stratification in chronic disease patien…

Effect of Foreperiod Duration and Handedness on Simple and Choice Auditory Reaction Time Among the Older People

2017

Objectives Cognitive functions such as reaction time undergo change with aging. Given the importance of preparation in response to reaction time in various life situations, this study aimed to examine the effect of various foreperiods (0.5, 1.5, 2.5, and 3.5 s), and handedness at the time of simple and choice auditory reaction time. Methods & Materials The current research followed a quasi-experimental methodology and was carried out using a self-made software. The study population comprised all old people living in Ahvaz City. Of them, 30 people were selected through purposive sampling method and allocated into two groups of right- and left-handed people. Each individual was randomly teste…

Adolfo Longhitano, Il vescovo di Catania Antonio Faraone (1530-1572). Tra fama di santit  e governo pastorale, Trapani, il Pozzo di Giacobbe, 2019 (D…

2022

Il volume pone questioni stimolanti, in particolare in merito alla costruzione dei modelli di santità che rispecchiano e rafforzano la coeva sensibilità religiosa, quando non ne creano di nuova. In questo contesto storiografico emerge chiaramente l’utilità euristica delle fonti agiografiche, soprattutto quando queste sono rilette e “corrette” alla luce di altre evidenze documentarie, nel caso in oggetto quelle attinenti la concreta (e spesso contrastata) azione pastorale di vescovi animati da spirito riformatore. The book focuses on stimulating issues, in particular the construction of holiness models that reflect and strengthen the contemporary religious sensibility, or maybe even do creat…

Exploring kainate receptor pharmacology using molecular dynamics simulations.

2010

Ionotropic glutamate receptors (iGluRs) are enticing targets for pharmaceutical research; however, the search for selective ligands is a laborious experimental process. Here we introduce a purely computational procedure as an approach to evaluate ligand–iGluR pharmacology. The ligands are docked into the closed ligand-binding domain and during the molecular dynamics (MD) simulation the bi-lobed interface either opens (partial agonist/antagonist) or stays closed (agonist) according to the properties of the ligand. The procedure is tested with closely related set of analogs of the marine toxin dysiherbaine bound to GluK1 kainate receptor. The modeling is set against the abundant binding data …

Structural Mechanism of N-Methyl-D-Aspartate Receptor Type 1 Partial Agonism

2012

N-methyl-D-aspartate (NMDA) receptors belong to a family of ionotropic glutamate receptors that contribute to the signal transmission in the central nervous system. NMDA receptors are heterotetramers that usually consist of two GluN1 and GluN2 monomers. The extracellular ligand-binding domain (LBD) of a monomer is comprised of discontinuous segments that form the functional domains D1 and D2. While the binding of a full agonist glycine to LBD of GluN1 is linked to cleft closure and subsequent ion-channel opening, partial agonists are known to activate the receptor only sub-maximally. Although the crystal structures of the LBD of related GluA2 receptor explain the mechanism for the partial a…

Trait Empathy associated with Agreeableness and rhythmic entrainment in a spontaneous movement to music task: Preliminary exploratory investigations

2017

The simulation theory of empathy suggests that we use motor processing to empathise, through modelling the actions of others. Similarly, research into embodied music cognition posits that music, particularly musical rhythm, is perceived as a motor stimulus. In both cases, the human Mirror Neuron System (MNS) is put forward as a potential underlying mechanism. If this is the case, some overlap may exist between the ability to empathise with others, and the ability to perceive rhythm in music. The present study investigated this relationship indirectly, through the study of individual differences in Trait Empathy and rhythmic entrainment. Undergraduate students ( N = 237) completed a questio…

A SIMPLE CULTIVATION CHAMBER FOR THE STUDY OF AERIAL REPRODUCTIVE ELEMENTS OF FUNGI

1970

Data from: Effects of undergrowth removal and edge proximity on ground beetles and vascular plants in urban boreal forests

2019

Urban forests are regularly managed for human safety and aesthetic reasons, but they are crucial habitat for many species. Removals of undergrowth occur commonly in these forests, yet the ecological consequences of these operations are poorly understood. We sampled ground beetles (Coleoptera, Carabidae) and vascular plants along 20-m edge gradients in Finnish urban forests, in five stands treated 0.5−2.5 years earlier with undergrowth removal and in five untreated stands. We hypothesized that undergrowth removal and edge proximity would benefit opportunistic and open-habitat species, whereas shady-habitat species would be affected negatively. (1) Regarding carabids, diversity and evenness i…

Un outil pour les politiques scolaires: "Prospective scolaire"

2012

Today, territorial, demographic evolutions can be quick, which encourages towns to reconsider the geography of public services. This is notably the case of General Councils that handle the localisation of public middle schools and establish school sectors. Carrying out these tasks requires taking into account several parameters: demographic dynamics, urban projects, social diversity within schools, and transportation conditions. The tool 'Prospective Scolaire' integrates these multiple data in order to help communities carry out their tasks.

Arbuscular mycorrhizal fungi positively affect growth of Ailanthus altissima (Mill.) Swingle seedlings and show a strong association with this invasi…

2015

Arbuscular mycorrhizal fungi (AMF) may promote plant invasion by enhancing plant performance and competitiveness. However, only a small number of studies have considered the interactions between local soil microbial communities and invasive plants, and even fewer have focused on alien trees. Ailanthus altissima is a serious problem in the Mediterranean Basin, where it has invaded many habitats. We investigated the symbiosis between A. altissima and indigenous AMF in two invaded, ecologically different Mediterranean woodlands. Mycorrhizal infection was high at both sites (> 60% of the root fragments were mycorrhizal), indicating that A. altissima roots may be infected by AMF under different …