Search results for "SIM"
showing 10 items of 10139 documents
Sequential formula translation
1983
The syntax of an algorithmic language such as ALGOL is conveniently described as a sequence of states indicated by an element called cellar. Transitions are controlled by admissible state- s ymbol pairs which may be represented by a transition matrix. This description of syntax furnishes at the same time an extremely simple rule for translating into machine programs statements in the algorithmic language. Sequential treatment, however, is not feasible in the case of certain optimizing processes such as recursive address calculation.
Waveguiding properties of a photonic crystal fiber with a solid core surrounded by four large air holes
2009
The polarization-dependent guiding properties of a hexagonal-lattice photonic crystal fiber with a solid-core surrounded by four large air holes are investigated. The appearance of a polarization dependent cutoff frequency, together with several parameters as the birefringence, the modal effective area, the group velocity dispersion and the polarization dependent loss are analyzed. A collection of fibers with different structural parameters were fabricated and characterized. An effective anti-guide structure from at least 450 nm to 1750 nm, a polarizing fiber with a polarization dependent loss of 16 dB/m at 1550 nm, and an endlessly singlemode polarization-maintaining fiber with group biref…
Input of P, N-(phosphanyl, amino)-ferrocene hybrid derivatives in late transition metals catalysis
2018
International audience; Unequally functionalized ferrocenes give access to valuable hemilabile reactivity in catalytic reaction. We address the synthesis of hybrid (P, N)-ferrocenyl compounds for which recent catalytic breakthrough applications have been reported, transversely in late transition metals chemistry. Palladium, nickel, rhodium, iridium, and emerging iron and gold catalysis are illustrated from selected examples, which include CC bond formation from cross-coupling and polymerization, allylic substitution, cyanation, hydroformylation, CH arylation and silylation and hydrogenation reactions.
GRASP with exterior path-relinking and restricted local search for the multidimensional two-way number partitioning problem
2017
In this work, we tackle multidimensional two-way number partitioning (MDTWNP) problem by combining GRASP with Exterior Path Relinking. In the last few years, the combination of GRASP with path relinking (PR) has emerged as a highly effective tool for finding high-quality solutions for several difficult problems in reasonable computational time. However, in most of the cases, this hybridisation is limited to the variant known as interior PR. Here, we couple GRASP with the "exterior form" of path relinking and perform extensive experimentation to evaluate this variant. In addition, we enhance our GRASP with PR method with a novel local search method specially designed for the MDTWNP problem. …
The Effect of Electronic Properties of Anodized and Hard Anodized Ti and Ti6Al4V on Their Reactivity in Simulated Body Fluid
2022
The electronic properties of barrier and porous layers on Ti and Ti6Al4V were studied. Barrier anodic oxides grown to 40 V on Ti and on Ti6Al4V are both n-type semiconductors with a band gap of 3.3 eV and 3.4 eV respectively, in agreement with the formation of amorphous TiO2. Anodizing to 200 V at 20 mA cm−2 in calcium acetate and β-glycerol phosphate disodium pentahydrate leads to the formation of Ca and P containing porous films with a photoelectrochemical behaviour dependent on the metallic substrate. A band gap of 3.2 eV and the flat band potential of −0.5 V vs Ag/AgCl were measured for the porous oxide on Ti, while optical transitions at 2.15 eV and a significantly more positive flat b…
Health risks of Simulium (Boophthora) erythrocephalum (De Geer, 1776) in the Valencian Autonomous Region, Eastern Spain
2021
The presence and distribution of Simulium erythrocephalum (De Geer, 1776) in the Valencian Autonomous Region is analyzed, an arthropod of medical-sanitary importance due to the marked anthropophilic characteristics exhibited and the tendency to carry out massive attacks. The increasing incidence registered in certain areas as a consequence of their hematophagy, and the meager availability of epidemiological, fauna, bioecological, and distribution data, have led to this study. A field study of 137 samplings was carried out from 2013 to the present in the 14 hydrographic basins of the Valencian Autonomous Region. The study variables were the presence or absence of preimaginal states, environm…
Identification of a new series of amides as non-covalent proteasome inhibitors
2014
Proteasome inhibition has emerged as an important therapeutic strategy for the treatment of multiple myeloma (MM) and some forms of lymphoma, with potential application in other types of cancers. 20S proteasome consists of three different catalytic activities known as chymotrypsin-like (ChT-L), trypsin-like (T-L), and, post-glutamyl peptide hydrolyzing (PGPH) or caspase-like (C-L), which are located respectively on the β5, β2, and β1 subunits of each heptameric β rings. Currently a wide number of covalent proteasome inhibitors are reported in literature; however, the less widely investigated non-covalent inhibitors might be a promising alternative to employ in therapy, because of the lack o…
Synthesis and biological activities of a new class of heat shock protein 90 inhibitors, designed by energy-based pharmacophore virtual screening
2013
The design through energy-based pharmacophore virtual screening has led to aminocyanopyridine derivatives as efficacious new inhibitors of Hsp90. The synthesized compounds showed a good affinity for the Hsp90 ATP binding site in the competitive binding assay. Moreover, they showed an excellent antiproliferative activity against a large number of human tumor cell lines. Further biological studies on the derivative with the higher EC50 confirmed its specific influence on the cellular pathways involving Hsp90.
Due riferimenti di Ammiano Marcellino all'imperatore Giuliano
2018
Si richiamano due riferimenti , nelle Res gestae di Ammiano Marcellino, ad interventi normativi dell'imperatore Giuliano, caratterizzati, entrambi, dall'obiettivo di esprimere in modo chiaro ed inequivoco il disposto legislativo; e si segnala che i due brani attestano, già alla fine del IV secolo, l'esigenza di precisione e di semplificazione del dettato delle leges che sarebbe stato poi perseguito su larga scala da Teodosio II con la sua codificazione.
Optical gain, spontaneous and stimulated emission of surface plasmon polaritons in confined plasmonic waveguide
2010
International audience; We develop a theoretical model to compute the local density of states in a confined plasmonic waveguide. Based on this model, we derive a simple formula with a clear physical interpretation for the lifetime modification of emitters embedded in the waveguide. The gain distribution within the active medium is then computed following the formalism developed in a recent work [Phys. Rev. B 78, 161401 (2008)], by taking rigorously into account the pump irradiance and emitters lifetime modifications in the system. We finally apply this formalism to describe gain–assisted propagation in a dielectric–loaded surface plasmon polariton waveguide.