Search results for "SIM"
showing 10 items of 10139 documents
Modified nonsink equation for permeability estimation in cell monolayers: comparison with standard methods.
2014
Cell culture permeability experiments are valuable tools in drug development and candidate selection, but the monolayer preparation protocols and the calculations procedures can affect the permeability estimation. Hence, standardization and method suitability demonstration are necessary steps for using permeability data for regulatory and in vivo prediction purposes. Much attention is usually paid to experimental procedure validation and less to the mathematical analysis of the results although the standard equations used imply several assumptions that many times do not hold. The aim of this study was to use a simulation strategy to explore the performance of a new proposed modified nonsink…
Oscillation criteria for even-order neutral differential equations
2016
Abstract We study oscillatory behavior of solutions to a class of even-order neutral differential equations relating oscillation of higher-order equations to that of a pair of associated first-order delay differential equations. As illustrated with two examples in the final part of the paper, our criteria improve a number of related results reported in the literature.
Ejection and collision orbits of the spatial restricted three-body problem
1985
We begin by describing the global flow of the spatial two body rotating problem, μ=0. The remainder of the work is devoted to study the ejection and collision orbits when μ>-0. We make use of the ‘blow up’ techniques to show that for any fixed value of the Jacobian constant the set of these orbits is diffeomorphic to S2×R. Also we find some particular collision-ejection orbits.
Existence of doubling measures via generalised nested cubes
2012
Working on doubling metric spaces, we construct generalised dyadic cubes adapting ultrametric structure. If the space is complete, then the existence of such cubes and the mass distribution principle lead into a simple proof for the existence of doubling measures. As an application, we show that for each $\epsilon>0$ there is a doubling measure having full measure on a set of packing dimension at most $\epsilon$.
The Liouville theorem and linear operators satisfying the maximum principle
2020
A result by Courr\`ege says that linear translation invariant operators satisfy the maximum principle if and only if they are of the form $\mathcal{L}=\mathcal{L}^{\sigma,b}+\mathcal{L}^\mu$ where $$ \mathcal{L}^{\sigma,b}[u](x)=\text{tr}(\sigma \sigma^{\texttt{T}} D^2u(x))+b\cdot Du(x) $$ and $$ \mathcal{L}^\mu[u](x)=\int \big(u(x+z)-u-z\cdot Du(x) \mathbf{1}_{|z| \leq 1}\big) \,\mathrm{d} \mu(z). $$ This class of operators coincides with the infinitesimal generators of L\'evy processes in probability theory. In this paper we give a complete characterization of the translation invariant operators of this form that satisfy the Liouville theorem: Bounded solutions $u$ of $\mathcal{L}[u]=0$ i…
Fixed point theorems on ordered metric spaces and applications to nonlinear elastic beam equations
2012
In this paper, we establish certain fixed point theorems in metric spaces with a partial ordering. Presented theorems extend and generalize several existing results in the literature. As application, we use the fixed point theorems obtained in this paper to study existence and uniqueness of solutions for fourth-order two-point boundary value problems for elastic beam equations.
On a new proof of Moser's twist mapping theorem
1976
Based on a new idea of the author, a new proof of J. Moser's twist mapping theorem is presented.
ANALYSIS OF A SPHERICAL HARMONICS EXPANSION MODEL OF PLASMA PHYSICS
2004
A spherical harmonics expansion model arising in plasma and semiconductor physics is analyzed. The model describes the distribution of particles in the position-energy space subject to a (given) electric potential and consists of a parabolic degenerate equation. The existence and uniqueness of global-in-time solutions is shown by semigroup theory if the particles are moving in a one-dimensional interval with Dirichlet boundary conditions. The degeneracy allows to show that there is no transport of particles across the boundary corresponding to zero energy. Furthermore, under certain conditions on the potential, it is proved that the solution converges in the long-time limit exponentially f…
Figures of equilibrium in close binary systems
1992
The equilibrium configurations of close binary systems are analyzed. The autogravitational, centrifugal and tidal potentials are expanded in Clairaut's coordinates. From the set of the total potential angular terms an integral equations system is derived. The reduction of them to ordinary differential equations and the determination of the boundary conditions allow a formulation of the problem in terms of a single variable.
A geometrical criterion for nonexistence of constant-sign solutions for some third-order two-point boundary value problems
2020
We give a simple geometrical criterion for the nonexistence of constant-sign solutions for a certain type of third-order two-point boundary value problem in terms of the behavior of nonlinearity in the equation. We also provide examples to illustrate the applicability of our results.