Search results for "SIMULATION"

Simulation d’un Affichage Tête Haute - Réalité Augmentée pour l’aide visuelle à la conduite automobile

2016

Head-Up Display is the emerging solution for visual aid while driving a car, especially during reduced visibility conditions, such as bad weather or when the road is poorly lighted. The HUD device allows to project virtual information in the central field of view of the driving scene, enabling the driver to keep his attention on the road. The visual perception of the driver is therefore augmented, with a coexistence between the real and virtual world. However, it is necessary to ensure an optimal setting in order to guarantee the good perception of the virtual information, and allow drivers to take appropriate actions at the right moment. This thesis project is dedicated to study three impo…

MATHEMATICAL MODEL AND SOFTWARE SIMULATION OF SUSPENSION'S SYSTEM FROM OPEL CARS

2014

Investigating Potential Alignments between Modelica Standard Library and SAREF Ontologies

2021

International audience; Simulation tools based on the Modelica language provide comprehensive modelling and simulation approaches for building energy systems. However, the simulation and optimisation of such systems are data-driven processes, lacking a common understanding of information structure within the process. This paper investigates the possible semantic alignments of the Smart Appliances REFerence (SAREF) ontology and its extension for building domain, SAREF4BLDG, with the Modelica Standard Library (MSL). Using the MSL, a residential heating system has been modelled in OpenModelica, an open-source modelling and simulation environment. Then, SAREF and its extension SAREF4BLDG semant…

Targeting SARS-CoV-2 Main Protease for Treatment of COVID-19: Covalent Inhibitors Structure-Activity Relationship Insights and Evolution Perspectives

2022

The viral main protease is one of the most attractive targets among all key enzymes involved in the SARS-CoV-2 life cycle. Covalent inhibition of the cysteine145 of SARS-CoV-2 MPRO with selective antiviral drugs will arrest the replication process of the virus without affecting human catalytic pathways. In this Perspective, we analyzed the in silico, in vitro, and in vivo data of the most representative examples of covalent SARS-CoV-2 MPRO inhibitors reported in the literature to date. In particular, the studied molecules were classified into eight different categories according to their reactive electrophilic warheads, highlighting the differences between their reversible/irreversible mech…

Synthesis, computational docking and biological evaluation of celastrol derivatives as dual inhibitors of SERCA and P-glycoprotein in cancer therapy.

2021

Abstract A series of eleven celastrol derivatives was designed, synthesized, and evaluated for their in vitro cytotoxic activities against six human cancer cell lines (A549, HepG2, HepAD38, PC3, DLD-1 Bax-Bak WT and DKO) and three human normal cells (LO2, BEAS-2B, CCD19Lu). To our knowledge, six derivatives were the first example of dipeptide celastrol derivatives. Among them, compound 3 was the most promising derivative, as it exhibited a remarkable anti-proliferative activity and improved selectivity in liver cancer HepAD38 versus human normal hepatocytes, LO2. Compound 6 showed higher selectivity in liver cancer cells against human normal lung fibroblasts, CCD19Lu cell line. The Ca2+ mob…

Additional Evidence for a Pulsar Wind Nebula in the Heart of SN 1987A from Multiepoch X-Ray Data and MHD Modeling

2022

Since the day of its explosion, supernova (SN) 1987A has been closely monitored to study its evolution and to detect its central compact relic. In fact, the formation of a neutron star is strongly supported by the detection of neutrinos from the SN. However, besides the detection in the Atacama Large Millimeter/submillimeter Array (ALMA) data of a feature that is compatible with the emission arising from a proto-pulsar wind nebula (PWN), the only hint for the existence of such elusive compact object is provided by the detection of hard emission in NuSTAR data up to ~ 20 keV. We report on the simultaneous analysis of multi-epoch observations of SN 1987A performed with Chandra, XMM-Newton and…

Outside-host phage therapy as a biological control against environmental infectious diseases

2018

Background Environmentally growing pathogens present an increasing threat for human health, wildlife and food production. Treating the hosts with antibiotics or parasitic bacteriophages fail to eliminate diseases that grow also in the outside-host environment. However, bacteriophages could be utilized to suppress the pathogen population sizes in the outside-host environment in order to prevent disease outbreaks. Here, we introduce a novel epidemiological model to assess how the phage infections of the bacterial pathogens affect epidemiological dynamics of the environmentally growing pathogens. We assess whether the phage therapy in the outside-host environment could be utilized as a biologi…

SITA/G - Description and simulation tools for public utility systems on IBM PC

1991

Abstract Simulation is a powerful and universal systems research tool for the analysis of discrete event model's functional quality. The simulation is used very widely in different areas of our everyday life. Simulation system SITA/G is produced in the Latvia University Research Institute of Mathematics and Computer Science. SITA/G softwares is proposed for using on IBM PC. SITA/G offers the facilities to describe, build and edit graphic programs by means of specification language SITA. Also the proposed system allows: 1) the visual demonstration of the simulation process of the graphic simulation programs; 2) obtaining of the probability characteristics of the systems under research. SITA/…

An ontology-based metamodel for multiagent-based simulations

2014

Multiagent-based simulations enable us to validate dierent use-case scenarios in a lot of application domains. The idea is to develop a realistic virtual environment to test particular domain-specic procedures. This paper presents our general framework for interactive multiagent-based simulations in virtual environments. The major contribution of this paper is the integration of the notion of ontology as a core element to the design process of a behavioral simulation. The proposed metamodel describes the concepts of a multiagent simulation using situated agents moving in a semantically enriched 3D environment. The agents perceive the geometric and semantic data in the surrounding environmen…

AX-PET: A novel PET detector concept with full 3D reconstruction

2009

We describe the concept and first experimental tests of a novel 3D axial Positron Emission Tomography (PET) geometry. It allows for a new way of measuring the interaction point in the detector with very high precision. It is based on a matrix of long Lutetium-Yttrium OxyorthoSilicate (LYSO) crystals oriented in the axial direction, each coupled to one Geiger Mode Avalanche Photodiode (G-APD) array. To derive the axial coordinate, Wave Length Shifter (WLS) strips are mounted orthogonally and interleaved between the crystals. The light from the WLS strips is read by custom-made G-APDs. The weighted mean of the signals in the WLS strips has proven to give very precise axial resolution. The ach…