Search results for "SIMULATION"

Bodies That Matter: Miniaturisation and the Origin(s) of ‘Art’

2020

Small things matter, especially in the so-called ‘arts’. From the visual arts to music and literature, ‘miniatures’ are a transcultural and transhistorical phenomenon that involves our aesthetic attitudes but also our everyday life, our emotional, social and cognitive life. Miniaturisation characterises our cognitive life and, of course, the ‘cognitive life of things’ that we produce, manipulate and discard. My paper is articulated into two sections: the first gives a quick overview of the miniatures of Homo sapiens, especially those of the paleolithic age, and a brief survey of the very challenging history of miniature-interpretation in twentieth-century philosophy of culture. In the secon…

The role of SAXS and molecular simulations in 3D structure elucidation of a DNA aptamer against lung cancer

2021

Aptamers are short, single-stranded DNA or RNA oligonucleotide molecules that function as synthetic analogs of antibodies and bind to a target molecule with high specificity. Aptamer affinity entirely depends on its tertiary structure and charge distribution. Therefore, length and structure optimization are essential for increasing aptamer specificity and affinity. Here, we present a general optimization procedure for finding the most populated atomistic structures of DNA aptamers. Based on the existed aptamer LC-18 for lung adenocarcinoma, a new truncated LC-18 (LC-18t) aptamer LC-18t was developed. A three-dimensional (3D) shape of LC-18t was reported based on small-angle X-ray scattering…

Structure‐ and Interaction‐Based Design of Anti‐SARS‐CoV‐2 Aptamers

2022

Aptamer selection against novel infections is a complicated and time-consuming approach. Synergy can be achieved by using computational methods together with experimental procedures. This study aims to develop a reliable methodology for a rational aptamer in silico et vitro design. The new approach combines multiple steps: (1) Molecular design, based on screening in a DNA aptamer library and directed mutagenesis to fit the protein tertiary structure; (2) 3D molecular modeling of the target; (3) Molecular docking of an aptamer with the protein; (4) Molecular dynamics (MD) simulations of the complexes; (5) Quantum-mechanical (QM) evaluation of the interactions between aptamer and target with …

Assessing the Open Trenches in Screening Railway Ground-Borne Vibrations by Means of Artificial Neural Network

2009

Reducing ground borne vibrations in urban areas is a very challenging task in railway transportation. Many mitigation measures can be considered and applied; among these open trenches are very effective. This paper deals with the study of the effect, in terms of reduction of vertical and horizontal displacements and velocities, of the open trenches. 2D FEM simulations have been performed and several open trench configurations have been analysed varying the main geometric features such as width and depth, distance from the rail, thickness of the soil layer over the rigid bedrock, type of the ground, ratio between the depth of the trench, and the thickness of the soil layer. For quantifying t…

Application of the DORA 2D Model to some sicilian catchments

2005

Steady-State Convective Acceleration Computation in Shallow Water Equations

1995

Valmiuksia tulevaisuuden työelämään simulaatiopelioppimisen kautta

2021

Tänä päivänä työtä tehdään yhä useammin hajautetuissa di-gitaalisissa ympäristöissä, joissa yhteisöllisten digitaalistenja 21. vuosisadan taitojen merkitys korostuu. Myös liike-toimintaosaamista tarvitaan tänä päivänä laajalti eri aloilla.Dynaamisten ja monitahoisten ilmiöiden oppiminen tapah-tuu parhaiten aidon kaltaisissa oppimisympäristöissä, kutensimulaatiopeliympäristöissä. Tutkimusaineistomme koostuusimulaatiopeliympäristössä toteutetun korkeakoulukurssinopiskelijoiden reflektiivisistä esseistä. Tutkimuksen tulostenperusteella voidaan esittää, että tapauksemme kaltaisen si-mulaatiopeleillä voidaan tukea monipuolisesti työelämäval-miuksien kehittymistä Work is increasingly being conduc…

Comparing Guidance via Implicit and Explicit Model Progressions in a Collaborative Inquiry-Based Learning Environment with Different-Aged Learners

2022

There is a need for research on the effect of different types of model progressions and learner age on learning and engagement in inquiry-based science settings. This study builds on the Scientific Discovery as Dual Search model to introduce less specific implicit model progression and compares them to the traditional explicit model progression. The data come from Finnish 8-, 10-, and 12-year-olds collaboratively using two different configurations of an inquiry-based learning environment about balance. Balance scale tasks were used to assess learning. Students also rated their situation-specific engagement. Both types of model progressions were beneficial for learning but there was no diffe…

Characterization of a cylindrical plastic β-detector with Monte Carlo simulations of optical photons

2017

In this work we report on the Monte Carlo study performed to understand and reproduce experimental measurements of a new plastic β-detector with cylindrical geometry. Since energy deposition simulations differ from the experimental measurements for such a geometry, we show how the simulation of production and transport of optical photons does allow one to obtain the shapes of the experimental spectra. Moreover, taking into account the computational effort associated with this kind of simulation, we develop a method to convert the simulations of energy deposited into light collected, depending only on the interaction point in the detector. This method represents a useful solution when extens…

Solar radiative effects of a Saharan dust plume observed during SAMUM assuming spheroidal model particles

2011

The solar optical properties of Saharan mineral dust observed during the Saharan Mineral Dust Experiment (SAMUM) were explored based on measured size-number distributions and chemical composition. The size-resolved complex refractive index of the dust was derived with real parts of 1.51–1.55 and imaginary parts of 0.0008–0.006 at 550 nm wavelength. At this spectral range a single scattering albedo ω o and an asymmetry parameter g of about 0.8 were derived. These values were largely determined by the presence of coarse particles. Backscatter coefficients and lidar ratios calculated with Mie theory (spherical particles) were not found to be in agreement with independently measured lidar data.…