Search results for "SINS"

Inhibition of KIF20A by BKS0349 reduces endometriotic lesions in a xenograft mouse model

2019

AbstractSeveral studies have suggested a possible etiological association between ovarian endometriosis and ovarian cancer. Evidence has shown that KIF20A overexpression might confer a malignant phenotype to ovarian tumors by promoting proliferation and inhibiting apoptosis. However, no data about the role of KIF20A in endometriosis have been described. In this study, the human endometrium (n = 4) was transfected by mCherry adenovirus and intraperitoneally implanted in mice. Subsequently, mice were divided in three groups (n = 8/group) that were treated with Vehicle, BKS0349 (KIF20A-antagonist) or cabergoline (dopamine receptor agonist) for 21 days. mCherry-labeled endometriotic lesions wer…

Risk of Low Energy Availability, Disordered Eating, Exercise Addiction, and Food Intolerances in Female Endurance Athletes

2022

Relative energy deficiency in sport (RED-S) is a complex syndrome describing health and performance consequences of low energy availability (LEA) and is common among female endurance athletes. Various underlying causes of LEA have been reported, including disordered eating behavior (DE), but studies investigating the association with exercise addiction and food intolerances are lacking. Therefore, the aim of this cross-sectional study was to investigate the association between DE, exercise addiction and food intolerances in athletes at risk of LEA compared to those with low risk. Female endurance athletes, 18–35 years, training ≥5 times/week were recruited in Norway, Sweden, Ireland, and Ge…

Comparison of condensed versus noncondensed cycling test methods and correlation to a 185 minutes’ indoor race simulation

2017

Master's thesis Sports Science ME517 - University of Agder 2017 Background: The validity of a currently used condensed indoor test protocols (C-TP) as measurement of competitive cycling performance is questioned. Purpose: C-TP contain testing of wattage at lactate threshold (LTW), maximum oxygen consumption (VO2max) and a Wingate anaerobic test (WAnT), performed consecutively during one session. As comparison these tests were separated and performed individually over three consecutive days, giving a non-condensed test protocol (NC-TP). The results were compared to a 5min all-out cycling test (5min all-out) performed individually and as part of a 185 minutes’ race simulation. Method: During …

Screening for Low Energy Availability in Male Athletes: Attempted Validation of LEAM-Q

2022

A questionnaire-based screening tool for male athletes at risk of low energy availability (LEA) could facilitate both research and clinical practice. The present options rely on proxies for LEA such screening tools for disordered eating, exercise dependence, or those validated in female athlete populations. in which the female-specific sections are excluded. To overcome these limitations and support progress in understanding LEA in males, centres in Australia, Norway, Denmark, and Sweden collaborated to develop a screening tool (LEAM-Q) based on clinical investigations of elite and sub-elite male athletes from multiple countries and ethnicities, and a variety of endurance and weight-sensiti…

Prevalence and associations of injury and illness among high school elite sport-students in the south of Norway

2018

Master's thesis Sports Science ME517 - University of Agder 2018 Introduction Youth participating in sports are often associated with a healthy lifestyle, however illness and injuries are frequently reported in sports. The aims for this master thesis were; (1) to examine the prevalence of sport injuries and illnesses among elite sport students at high school with regard to sport group and (2) to examine anthropometry, bone health, performance variables, energy availability and sleep time with associations to sport injuries and illness prevalence in the same sample. Methods Thirty-six high school elite sport students, endurance athletes (n=24) and ball game athletes (n=12) [age: 16.3±0.2 year…

Classification of EEG signals for prediction of epileptic seizures

2022

Epilepsy is a common brain disorder that causes patients to face multiple seizures in a single day. Around 65 million people are affected by epilepsy worldwide. Patients with focal epilepsy can be treated with surgery, whereas generalized epileptic seizures can be managed with medications. It has been noted that in more than 30% of cases, these medications fail to control epileptic seizures, resulting in accidents and limiting the patient’s life. Predicting epileptic seizures in such patients prior to the commencement of an oncoming seizure is critical so that the seizure can be treated with preventive medicines before it occurs. Electroencephalogram (EEG) signals of patients recorded to ob…

EPOXY RESIN SYSTEMS CURABLE BY HIGH ENERGY RADIATION FOR ADVANCED COMPOSITES. STUDY OF THE EFFECTS OF PROCESS TEMPERATURE ON THERMAL PROPERTIES

2006

EPOXY RESIN VS BIOCERAMIC: SYSTEMATIC REVIEW WITH META-ANALYSIS

2021

Unpacking Relational Dignity: In Pursuit of an Ethic of Care for Outdoor Therapies

2022

Dignity is a universal principle that requires us to treat every person as having worth beyond who a particular person is or what they do. Dignity is a complex and sometimes contested idea, that at times can be compromised in health care and allegedly also within the practice of outdoor therapy. Outdoor therapies comprise a range of therapeutic approaches including nature-based therapy, adventure therapy, animal-assisted therapy, forest therapy, wilderness therapy, surf therapy, and more. Within the literature of outdoor therapies there has been limited research on ethics related to common understandings of care concepts such as relational dignity and human rights. The aim of this paper is …

Exploring Moderators of the Effect of High vs. Low-to-Moderate Intensity Exercise on Cardiorespiratory Fitness During Breast Cancer Treatment – Analy…

2022

IntroductionThe results from the physical training and cancer randomized controlled trial (Phys-Can RCT) indicate that high intensity (HI) strength and endurance training during (neo-)adjuvant cancer treatment is more beneficial for cardiorespiratory fitness (CRF, measured as peak oxygen uptake [VO2peak]) than low-to-moderate intensity (LMI) exercise. Adherence to the exercise intervention and demographic or clinical characteristics of patients with breast cancer undergoing adjuvant treatment may moderate the exercise intervention effect on VO2peak. In this study, the objective was to investigate whether baseline values of VO2peak, body mass index (BMI), time spent in moderate- to vigorous-…