Search results for "SINS"
showing 10 items of 1323 documents
Development of digital health messages for rural populations in Tanzania: Multi- And interdisciplinary approach
2021
Background Health workers have traditionally delivered health promotion and education to rural communities in the Global South in paper leaflet formats or orally. With the rise of digital technologies, health promotion and education can be provided in innovative and more effective formats, which are believed to have a higher impact on disease prevention and treatment. Objective The aim of this tutorial is to illustrate how a multi- and interdisciplinary approach can be applied in the design process of digital health messages for use in the Global South. Methods The multi- and interdisciplinary team of the Non-discriminating access for Digital Inclusion (DigI) project digitalized and custom…
Gravides røykevaner i Aust-Agder : rapport fra et prosjekt i regi av Høgskolen i Agder, på oppdrag av Fylkesmannen i Aust-Agder
2006
"Prosjektets varighet: 1/1-2004 - 31/12-2004" Målgruppe for surveyundersøkelsen var samtlige kvinner hjemmehørende i Aust-Agder som fødte fra 1/1-04 tom 31/12-2004. Det ble det utlevert 851 spørreskjemaer. 734 svar innkom, dvs. en svarprosent på 86,3 %. 241 kvinner (32,8 %) bekreftet at de røkte ved svangerskapets start. Undersøkelsen viste at hvorvidt kvinnene definerte seg som røykere i stor grad var avhengig av hvordan spørsmål om røykevaner ble stilt. Alle grader av røyking inkludert angav 200 (27,2 %) av kvinnene at de røkte etter fødsel. Røykenedgang i løpet av svangerskapet i forhold til totalutvalget var altså på 5,6 %. Det vil si at 17 % av de som røkte ved svangerskapets start slu…
Hiukkasherätteinen röntgen-emissio ohutkalvojen analysoinnissa
2013
Tässä tutkielmassa tavoitteena oli analysoida ohutkalvoja hiukkasherätteisellä röntgen-emissiolla (PIXE) käyttäen apuna takaisinsirontaa. Erityisesti tavoitteena oli selvittää pystytäänkö PIXEllä saamaan lisätietoa tilanteissa, joissa pelkän takaisinsironnan avulla ei saada tarkkaa tietoa. Tähän tarkoitukseen tutkittiin kahta eri tapausta: lähekkäisten alkuaineiden suhteen määritys ja pienten epäpuhtauksien määritys. Lähekkäisten alkuaineiden analysoinnissa käytettiin GeCu-näytettä. Täs- sä tapauksessa 1,5 MeV:n takaisinsirontaspektristä ei pystytty erottamaan germaniumin ja kuparin piikkejä, mutta se pystyttiin tekemään 3,0 MeV:n energialla. PIXE-mittauksissa germaniumin ja kuparin piikit …
Strutture deformative sindeposizionali nelle calcareniti Pleistoceniche del settore orientale dell'Isola di Favignana (Sicilia, Italia)
2013
ST elevāciju miokarda infarkta noteicošās artērijas intravaskulārās ultraskaņas audu raksturojuma saistība ar aterosklerozes asins biomarķieriem un s…
2013
Anotācija ST elevāciju miokarda infarkta gadījumā (STEMI) patofizioloģiskais substrāts ir rupturējusi vai erodējusi panga un tromboze. Šajā darbā veicām iMap IVUS audu analīzi STEMI mērķa bojājumiem 75 pacientiem, noteicām asinīs aterosklerozes biomarķierus un veicām 10 mēnešu apsekojumu. Mūsu rezultāti parādīja augstu nekrotisko audu daudzumu mērķa bojājumā un augstu, bet salīdzinoši zemāku, proksimālajā segmentā. Proksimālajā segmentā 10 mēnešu laikā samazinājās lipīdu audu daudzums par 10,2%. Neointimai 10 mēnešus pēc stenta implantācijas bija raksturīgs stabilāks audu sastāvs pēc iMap IVUS nekā natīvai aterosklerotiskai pangai šajā artērijā. Asins aterosklerozes biomarķieru saistību ar …
Dual Antimicrobial and Antiproliferative Activity of TcPaSK Peptide Derived from a Tribolium castaneum Insect Defensin
2021
Antimicrobial peptides (AMPs) found in the innate immune system of a wide range of organisms might prove useful to fight infections, due to the reported slower development of resistance to AMPs. Increasing the cationicity and keeping moderate hydrophobicity of the AMPs have been described to improve antimicrobial activity. We previously found a peptide derived from the Tribolium castaneum insect defensin 3, exhibiting antrimicrobial activity against several human pathogens. Here, we analyzed the effect against Staphyloccocus aureus of an extended peptide (TcPaSK) containing two additional amino acids, lysine and asparagine, flanking the former peptide fragment in the original insect defensi…
Molecular basis of human Usher syndrome: deciphering the meshes of the Usher protein network provides insights into the pathomechanisms of the Usher …
2006
Usher syndrome (USH) is the most frequent cause of combined deaf-blindness in man. It is clinically and genetically heterogeneous and at least 12 chromosomal loci are assigned to three clinical USH types, namely USH1A-G, USH2A-C, USH3A (Davenport, S.L.H., Omenn, G.S., 1977. The heterogeneity of Usher syndrome. Vth Int. Conf. Birth Defects, Montreal; Petit, C., 2001. Usher syndrome: from genetics to pathogenesis. Annu. Rev. Genomics Hum. Genet. 2, 271-297). Mutations in USH type 1 genes cause the most severe form of USH. In USH1 patients, congenital deafness is combined with a pre-pubertal onset of retinitis pigmentosa (RP) and severe vestibular dysfunctions. Those with USH2 have moderate to…
The GRIP1/14-3-3 Pathway Coordinates Cargo Trafficking and Dendrite Development
2014
SummaryRegulation of cargo transport via adaptor molecules is essential for neuronal development. However, the role of PDZ scaffolding proteins as adaptors in neuronal cargo trafficking is still poorly understood. Here, we show by genetic deletion in mice that the multi-PDZ domain scaffolding protein glutamate receptor interacting protein 1 (GRIP1) is required for dendrite development. We identify an interaction between GRIP1 and 14-3-3 proteins that is essential for the function of GRIP1 as an adaptor protein in dendritic cargo transport. Mechanistically, 14-3-3 binds to the kinesin-1 binding region in GRIP1 in a phospho-dependent manner and detaches GRIP1 from the kinesin-1 motor protein …
Isolation of the silicatein-α interactor silintaphin-2 by a novel solid-phase pull-down assay.
2011
The skeleton of siliceous sponges consists of amorphous biogenous silica (biosilica). Biosilica formation is driven enzymatically by means of silicatein(s). During this unique process of enzymatic polycondensation, skeletal elements (spicules) that enfold a central proteinaceous structure (axial filament), mainly comprising silicatein, are formed. However, only the concerted action of silicatein and other proteins can explain the genetically controlled diversity of spicular morphotypes, from simple rods with pointed ends to intricate structures with up to six rays. With the scaffold protein silintaphin-1, a first silicatein interactor that facilitates the formation of the axial filament and…
The role of the silicatein-alpha interactor silintaphin-1 in biomimetic biomineralization.
2008
Biosilicification in sponges is initiated by formation of proteinaceous filaments, predominantly consisting of silicateins. Silicateins enzymatically catalyze condensation of silica nanospheres, resulting in symmetric skeletal elements (spicules). In order to create tailored biosilica structures in biomimetic approaches it is mandatory to elucidate proteins that are fundamental for the assembly of filaments. Silintaphin-1 is a core component of modularized filaments and also part of a spicule-enfolding layer. It bears no resemblance to other proteins, except for the presence of an interaction domain that is fundamental for its function as scaffold/template. In the presence of silicatein sil…