Search results for "SISTA"

Silicate modulates the cross-talk between osteoblasts (SaOS-2) and osteoclasts (RAW 264.7 cells): inhibition of osteoclast growth and differentiation

2012

It has been shown that inorganic monomeric and polymeric silica/silicate, in the presence of the biomineralization cocktail, increases the expression of osteoprotegerin (OPG) in osteogenic SaOS-2 sarcoma cells in vitro. In contrast, silicate does not affect the steady-state gene expression level of the osteoclastogenic ligand receptor activator of NF-κB ligand (RANKL). In turn it can be expected that the concentration ratio of the mediators OPG/RANKL increases in the presence of silicate. In addition, silicate enhances the growth potential of SaOS-2 cells in vitro, while it causes no effect on RAW 264.7 cells within a concentration range of 10-100 µM. Applying a co-cultivation assay system,…

Case series of fluoroscopic findings and 3D reconstruction of human spinal MRIs of the space of Okada.

2020

Objective To better understand the unexpected spread of contrast medium observed by conventional fluoroscopic X-ray images during standard neuraxial techniques used in the treatment of pain. The support of 3D reconstruction of MRI images of structures within the lumbar spine was used to better understand the space of Okada. Methods Lumbar facet joint and epidural corticosteroid injections in five patients under fluoroscopic guidance with loss of resistance to air or saline to identify the facet joints or epidural space. Next, in a retrospective study, the authors examined the retrodural space of Okada and the neighboring tissues with 3D reconstruction of spinal MRIs of seven patients withou…

Comparison of frictional resistance between passive self-ligating brackets and slide-type low-friction ligature brackets during the alignment and lev…

2019

Background To compare the frictional resistance between passive self-ligating brackets and conventional brackets with low-friction ligature under bracket/archwire and root/bone interface during dental alignment and leveling. Material and methods A tridimensional model of the maxilla and teeth of a patient treated with conventional brackets, and slide ligatures was generated employing the SolidWorks modeling software. SmartClip self-ligating brackets and Logic Line conventional brackets were assembled with slide low-friction ligatures, utilizing archwires with different diameters and alloys used for the alignment and leveling stage. Friction caused during the bracket/archwire interface and s…

New Modalities in Knee Osteoarthritis Treatment Using Autologous Bone Marrow-Derived Mononuclear Cells

2018

Abstract The clinical effects on knee osteoarthritis (OA) symptoms and tissue structure were evaluated after bone marrow-derived mononuclear cell intraarticular injection. A group of 32 patients with 34 knee joints in stage II–III osteoarthritis were treated by intraarticular injection of mononuclear cell suspension. Clinical results were obtained by KOOS (Knee Osteoarthritis Outcome Score) and KSS (Knee Society Score) scores during a 12 months follow-up period. Radiological evaluation was performed using magnetic resonance imaging. A comparison with a control group of 28 patients treated with routinely used three hyaluronic acid intra-articular injections was made. No adverse effects were …

An update on the relationships between rheumatoid arthritis and atherosclerosis

2010

Rheumatoid arthritis is a chronic inflammatory disease. Cardiovascular events are the most important cause of mortality and morbidity in patients with rheumatoid arthritis. Beyond the traditional cardiovascular risk factors, chronic systemic inflammation has been shown to be a crucial factor in atherosclerosis development and progression from endothelial dysfunction to plaque rupture and thrombosis. Many studies have shown that atherosclerosis is not a passive event like accumulation of lipids in the vessel walls; by contrast, it represents an active inflammation of the vessels. Inflammatory cells such as macrophages, monocytes and T cells play important roles in the development of both rhe…

Stiffness and Reinforcement Effect of electrical Resistance Strain Gauges

2007

:  The increasing use of low-modulus materials, on which the reinforcement effect of the electrical resistance strain gauge is not negligible, has re-opened the research interest into this issue. This study deals with the evaluation of stiffness, and of the strain gauge Young's modulus involved in the estimation of both the global and the local reinforcement effect; the relationship between the strain gauge stiffness and the local reinforcement effect is also analysed. In particular, the experimental technique used to determine the stiffness of some commercial strain gauges is described. The results show that the strain gauge stiffness alone does not permit an accurate evaluation of the loc…

Association of low 25-hydroxyvitamin D concentrations with elevated parathyroid hormone concentrations and low cortical bone density in early puberta…

2003

Background: Very few studies have evaluated both parathyroid hormone (PTH) and 25-hydroxyvitamin D [25(OH)D] and their effects on bone mass in children. Objective: We studied the associations of serum 25(OH)D and intact PTH (iPTH) with bone mineral content (BMC) and bone mineral density (BMD) at different bone sites and the relation between serum 25(OH)D and iPTH in early pubertal and prepubertal Finnish girls. Design: The subjects were 10‐12-y-old girls (n = 193) at Tanner stage 1 or 2, who reported a mean (± SD) dietary calcium intake of 733 ± 288 mg/d. 25(OH)D, iPTH, tartrate-resistant acid phosphatase 5b (TRAP 5b), urinary calcium excretion, BMC, areal BMD, and volumetric BMD were asses…

2020

The occupation of dental assistants (DAs) involves many health risks of the musculoskeletal system due to static and prolonged work, which can lead to musculoskeletal disorders (MSDs). The aim of the study was to investigate the prevalence of MSDs in DAs in Germany. Methods: For this purpose, an online questionnaire analyzed 406 (401 female participants and 5 male participants, 401w/5m) DAs. It was based on the Nordic Questionnaire (lifetime, 12-month, and seven-day MSDs’ prevalence separated into neck, shoulder, elbow, wrist, upper back, lower back, hip, knee, and ankle), and occupational and sociodemographic questions as well as questions about specific medical conditions. Results: 98.5% …

Prévenir et réduire les risques de sélection de résistances : de la théorie à la pratique, des pistes pour améliorer la durabilité des PPP

2015

SPEPôle GEAPSICT2communication orale invitée, résumé; La résistance est le résultat inéluctable de la sélection exercée par les PPP sur les populations de bio-agresseurs. On ne peut pas empêcher une résistance d’évoluer, mais on peut retarder substantiellement son évolution en mettant en place des stratégies appropriées avant (prévention) et après (gestion) la détection des premiers individus résistants. Le point-clef à retenir pour cela est que plus le contrôle d’un bio-agresseur est basé sur une chimie peu diversifiée, plus le risque de sélectionner rapidement une résistance est élevé. Un exemple type de ce qu’il ne faut pas faire est de contrôler un bio-agresseur présent sur de grandes s…

Réduire les risques de sélection de résistances : de la théorie à la pratique, des pistes pour améliorer la durabilité des PPP

2013

National audience; La résistance est le résultat inéluctable de la sélection exercée par les PPP sur les populations de bio-agresseurs. À terme, on ne peut pas empêcher une résistance d’évoluer. Mais on peut retarder substantiellement cette évolution. Le point-clef à retenir pour ce faire est que plus une pression de sélection est répétée dans le temps et homogène, plus elle conduit rapidement et efficacement à une adaptation. Autrement dit, plus les techniques de contrôle déployées contre un bio-agresseur sont peu diverses, plus le risque de sélectionner rapidement une résistance est élevé. En agriculture, un exemple type d’application d’une pression de sélection homogène et répétée est de…