Search results for "SISTA"

Acute Neuromuscular and Hormonal Responses to Power, Strength, and Hypertrophic Protocols and Training Background

2022

This study investigated how two slightly different athlete groups would differ in acute neuromuscular and endocrine responses to specific resistance exercise loadings and recovery compared to untrained participants. Power athletes (PA, n = 8), strength athletes (SA, n = 8) and non-athletes (NA, n = 7) performed power (PL, 7 × 6 × 50% of 1RM), maximal strength (MSL, 7 × 3 × 3RM), and hypertrophic (HL, 5 × 10 × 10RM) loadings in Smith-machine back-squat. Neuromuscular performance, serum testosterone, growth hormone, and cortisol concentrations, and blood lactate (BL) were measured before (Pre), at Mid and after (Post) loading, and after recovery for 24 and 48 h. All loadings led to acute decr…

Effects of Task-Specific and Strength Training on Simulated Military Task Performance in Soldiers.

2020

A soldier’s occupational physical task requirements are diverse and varied. However, the type of physical training that most effectively improves soldiers’ occupational task requirements has not been studied previously. The purpose of this study was to determine the important strength characteristics for soldiers during a repeated simulated military task course, and the type of training that may be effective to improve these abilities during a specialized military training period. Forty-two (n = 42) soldiers participated in the study. They were divided into three training groups; a soldier task-specific training group (TSG, n = 17), a strength training group (STG, n = 15), and a control gro…

Onset of Insulin Resistance in Hippocampal Synapses After Traumatic Brain Injury: Relevance to Alzheimer’s disease and Therapeutic Implications

Use of driving simulators for advanced driver assistance Systems evaluation in emergency situations

2012

Introducing advanced driver assistance systems in cars has numerous consequences, particularly on drivers' behavior and their interaction with the vehicle. The expected safety benefits of assistance systems can thus be jeopardized. In order to assess the actual safety benefits, driving simulators offer a safe and cheap alternative. This doctoral work relies on experiments carried out on driving simulators with different assistance systems. A first experimental part focuses on longitudinal control assistance: we studied drivers' familiarization with a Forward Collision Warning system in critical situations. A second experimental part focuses on lateral control assistance: we studied drivers'…

Surrogate-assisted evolutionary multiobjective shape optimization of an air intake ventilation system

2017

We tackle three different challenges in solving a real-world industrial problem: formulating the optimization problem, connecting different simulation tools and dealing with computationally expensive objective functions. The problem to be optimized is an air intake ventilation system of a tractor and consists of three computationally expensive objective functions. We describe the modeling of the system and its numerical evaluation with a commercial software. To obtain solutions in few function evaluations, a recently proposed surrogate-assisted evolutionary algorithm K-RVEA is applied. The diameters of four different outlets of the ventilation system are considered as decision variables. Fr…

The construction of academic identity in the changes of Finnish higher education

2013

This article sets out to explore how academics make sense of the current transformations of higher education and what kinds of academic identities are thereby constructed. Based on a narrative analysis of 42 interviews with Finnish academics, nine narratives are discerned, each providing a different answer as to what it means to be an academic in the present-day university. Narratives of resistance, loss, administrative work overload and job insecurity are embedded in a regressive storyline, describing deterioration of academic work and one's standing. In a sharp contrast, narratives of success, mobility and change agency rely on a progressive storyline which sees the current changes in a p…

Ultraviolet B radiation induced alterations in immune function of fish : in relation to habitat preference and disease resistance

2009

Runsas altistuminen auringolle on tunnetusti haitallista ihmisten ja eläinten hyvinvoinnille. Eveliina Markkula tutki väitöskirjatyössään, miten ultravioletti B (UVB) -säteilylle altistuminen vaikuttaa kalojen vastustuskykyyn ja tautialttiuteen.- Ilmakehän otsonikerroksen oheneminen viime vuosikymmenten aikana on johtanut UVB-säteilyn lisääntymiseen maan pinnalla. UVB-säteily tunkeutuu myös kirkkaisiin järvi- ja merivesiin ja voi näin aiheuttaa haittaa kaloille, Markkula kertoo.UVB-säteilyn on jo aiemmin todettu lisäävän kalojen varhaisten elinvaiheiden epämuodostumia ja kuolleisuutta. Kertaluonteinenkin altistuminen lampuilla tuotetulle UVB-säteilylle aiheuttaa muutoksia kalan immuunijärje…

The role of circulating and exosomal miRNAs as biomarkers of drug-resistant epilepsy

Epilepsy is estimated to affect about 65 million individuals worldwide, with up to 30 percent of drug-resistant patients who do not have remission despite appropriate therapy with antiepileptic drugs (AEDs). Therefore, it is important to distinguish drug-resistant epilepsy early in the course of disease to start a specific therapeutical approach as soon as possible. Recently circulating miRNAs have been proposed as promising biomarkers for different neurodegenerative disorders, including epilepsy. MiRNAs are a class of small non-coding RNA that regulate gene expression at a post-transcriptional level. The regulatory mechanisms controlling translation of mRNA transcripts represents to date a…

Production and Properties of Starch Citrates—Current Research

2020

Starch modification by chemical reaction is widely used to improve the properties of native starch. Modified by citric acid, starch is characterized by specific properties resulting from the presence of citrate residues and as a result of cross-linking starch. The chemicals used for preparing starch citrates are safe for human health and the natural environment compared to the harsh chemicals used for conventional modifications. Starch citrates are traditionally produced by heating starch–citric acid mixtures in semi-dry conditions or by a heat moisture treatment. The conditions of the modification process (roasting temperature, heating time, citric acid dose) and the botanic source or geno…

MTOR inhibitor-based combination therapies for pancreatic cancer

2018

Background: Although the mechanistic target of rapamycin (MTOR) kinase, included in the mTORC1 and mTORC2 signalling hubs, has been demonstrated to be active in a significant fraction of patients with pancreatic ductal adenocarcinoma (PDAC), the value of the kinase as a therapeutic target needs further clarification. Methods: We used Mtor floxed mice to analyse the function of the kinase in context of the pancreas at the genetic level. Using a dual-recombinase system, which is based on the flippase-FRT (Flp-FRT) and Cre-loxP recombination technologies, we generated a novel cellular model, allowing the genetic analysis of MTOR functions in tumour maintenance. Cross-species validation and pha…