Search results for "SKIN"
showing 10 items of 3630 documents
Skin Immunomodulation during Regeneration: Emerging New Targets
2021
Adipose-Derived Stem Cells (ADSC) are present within the hypodermis and are also expected to play a pivotal role in wound healing, immunomodulation, and rejuvenation activities. They orchestrate, through their exosome, the mechanisms associated to cell differentiation, proliferation, and cell migration by upregulating genes implicated in different functions including skin barrier, immunomodulation, cell proliferation, and epidermal regeneration. ADSCs directly interact with their microenvironment and specifically the immune cells, including macrophages and T and B cells, resulting in differential inflammatory and anti-inflammatory mechanisms impacting, in return, ADSCs microenvironment and …
Hopes and Limits of Adipose-Derived Stem Cells (ADSCs) and Mesenchymal Stem Cells (MSCs) in Wound Healing
2020
Adipose tissue derived stem cells (ADSCs) are mesenchymal stem cells identified within subcutaneous tissue at the base of the hair follicle (dermal papilla cells), in the dermal sheets (dermal sheet cells), in interfollicular dermis, and in the hypodermis tissue. These cells are expected to play a major role in regulating skin regeneration and aging-associated morphologic disgraces and structural deficits. ADSCs are known to proliferate and differentiate into skin cells to repair damaged or dead cells, but also act by an autocrine and paracrine pathway to activate cell regeneration and the healing process. During wound healing, ADSCs have a great ability in migration to be recruited rapidly…
Maturation of Epidermal Langerhans Cells In Vitro Is Accompanied by Downregulation of 4F2 (CD98) as Determined by Differential Display
1998
Following short-term culture, Langerhans cells mature morphologically and functionally into potent immunostimulatory cells. As regulation of gene expression accompanies this maturation process, it is likely that differentially expressed genes are involved in the maturation events. Using the recently described method of differential display, we generated cDNA expression patterns starting with mRNA of murine epidermal Langerhans cells isolated either directly (fLC) or following 3 d cultivation (cLC). Five hundred putative differentially expressed cDNA fragments were recovered from the gel. For a part of the fragments differential expression was confirmed by dot blot and Southern hybridization…
Dissimilar titanium-aluminum skin-stringer joints by FSW: process mechanics and performance
2022
Ever since its inception, friction stir welding (FSW) is being validated by scientific investigations as an effective substitution for fusion-based conventional joining technologies. One of the main strengths of FSW is the possibility to produce dissimilar joints, even using materials extremely different in terms of thermal and mechanical properties. The goal of the present research is to investigate the feasibility of both Al-Ti skin-stringer and reversed Ti-Al skin-stringer joints, highlighting the effect of joint configuration and main process parameters on material flow and joint mechanical properties. During the investigation, the essentiality of the proper heat input through balancing
Analysis of the molecular mechanisms that mediate the therapeutic actions of glucocorticoids in skin
2017
Tesis doctoral 189 páginas, 53 figuras, 1 tabla como material suplementario
Comparison of Machine Learning Methods in Stochastic Skin Optical Model Inversion
2020
In this study, we compare six different machine learning methods in the inversion of a stochastic model for light propagation in layered media, and use the inverse models to estimate four parameters of the skin from the simulated data: melanin concentration, hemoglobin volume fraction, and thicknesses of epidermis and dermis. The aim of this study is to determine the best methods for stochastic model inversion in order to improve current methods in skin related cancer diagnostics and in the future develop a non-invasive way to measure the physical parameters of the skin based partially on the results of the study. Of the compared methods, which are convolutional neural network, multi-layer …
Microneedle-Based Delivery: An Overview of Current Applications and Trends
2020
Microneedle arrays (MNA) are considered as one of the most promising resources to achieve systemic effects by transdermal delivery of drugs. They are designed as a minimally invasive, painless system which can bypass the stratum corneum, overcoming the potential drawbacks of subcutaneous injections and other transdermal delivery systems such as chemical enhancers, nano and microparticles, or physical treatments. As a trendy field in pharmaceutical and biomedical research, its applications are constantly evolving, even though they are based on very well-established techniques. The number of molecules administered by MNA are also increasing, with insulin and vaccines administration being the …
Septic skin lesions: An uncommon manifestation of peripheral prosthetic vascular graft infection
2014
Peripheral prosthetic vascular graft infection following lower limb surgical revascularization is a relatively rare but serious condition. A case of early infection and occlusion of a above-knee femoro-popliteal artery prosthetic bypass is here reported. It was accompanied by acute lower limb ischemia, fever and distally by embolic septic skin lesions.
Analysis of a database to predict the result of allergy testing in vivo in patients with chronic nasal symptoms.
2014
Background This article uses the logistic regression model for diagnostic decision making in patients with chronic nasal symptoms. We studied the ability of the logistic regression model, obtained by the evaluation of a database, to detect patients with positive allergy skin-prick test (SPT) and patients with negative SPT. The model developed was validated using the data set obtained from another medical institution. Methods The analysis was performed using a database obtained from a questionnaire administered to the patients with nasal symptoms containing personal data, clinical data, and results of allergy testing (SPT). All variables found to be significantly different between patients w…
Nostalgia, community and resistance : Counter-cultural politics in a Finnish skinzine
2019
Culture and community building are an essential part of the appeal of the far-right and fascist movements. Studying their cultural products is therefore important for a deeper understanding of the movement and their modus operandi. One elemental part of their culture are the so-called zines, small-scale do-it-yourself magazines intended for scene members. In certain respects, the far-right zines, skinzines, follow the forms and trends of other underground publications, especially punk-zines, with which they also share the resistance identity as stigmatized and marginalized actors. However, the political visions in skinzines are more or less opposite to ‘democratic zines’, creating certain t…