Search results for "SLM"
showing 10 items of 11 documents
Mucoadhesive solid lipid microparticles for controlled release of a corticosteroid in the chronic obstructive pulmonary disease treatment.
2017
Therapeutic efficacy of inhaled drugs is limited by rapid clearance from the site of action due to absorption into systemic circulation or metabolic degradation by alveolar macrophages. Drug delivery systems offer new solutions to clinical problems especially in the treatment of pulmonary diseases. In particular, Solid Lipid Microparticles (SLM) in the range of 3-5 µm are suggested as systems for delivery of therapeutics to the lung as, because of their size, they are able to deposit into secondary bronchi, avoiding systemic absorption typical of alveolar regions. Here, we describe two novel different SLMs prepared with chitosan and alginate for sustained release of fluticasone propionate (…
Sng1 associates with Nce102 to regulate the yeast Pkh–Ypk signalling module in response to sphingolipid status
2016
International audience; All cells are delimited by biological membranes, which are consequently a primary target of stress-induced damage. Cold alters membrane functionality by decreasing lipid fluidity and the activity of membrane proteins. In Saccharomyces cerevisiae, evidence links sphingolipid homeostasis and membrane phospholipid asymmetry to the activity of the Ypk1/2 proteins, the yeast orthologous of the mammalian SGK1-3 kinases. Their regulation is mediated by different protein kinases, including the PDK1 orthologous Pkh1/2p, and requires the function of protein effectors, among them Nce102p, a component of the sphingolipid sensor machinery. Nevertheless, the mechanisms and the act…
The Effect of Building Direction on Microstructure and Microhardness during Selective Laser Melting of Ti6Al4V Titanium Alloy
2021
AbstractDuring the last few years, additive manufacturing has been more and more extensively used in several industries, especially in the aerospace and medical device fields, to produce Ti6Al4V titanium alloy parts. During the Selective Laser Melting (SLM) process, the heterogeneity of finished product is strictly connected to the scan strategies and the building direction. An optimal managing of the latter parameters allows to better control and defines the final mechanical and metallurgical properties of parts. Acting on the building direction it is also possible to optimize the critical support structure. In particular, more support structures are needed for the sample at 0°, while very…
Sample building orientation effect on porosity and mechanical properties in Selective Laser Melting of Ti6Al4V titanium alloy
2022
Abstract In recent decades, the focus of research has shifted towards new production technologies with the aim of optimizing production and reducing costs. These innovative technologies include additive manufacturing processes as Selective Laser Melting (SLM). The analysis of the literature on the identification of optimal building orientation to maximize the mechanical properties and minimize porosity of the final products highlights contrasting results, denoting that the thermomechanical complexity of the process, as associated with the variation of the building orientation, has not been fully clarified. A study in which the building orientation effect was evaluated together with the geom…
Fast multi-directional DSLM for confocal detection without striping artifacts
2020
In recent years light-sheet fluorescence microscopy (LSFM) has become a cornerstone technology for neuroscience, improving the quality and capabilities of 3D imaging. By selectively illuminating a single plane, it provides intrinsic optical sectioning and fast image recording, while minimizing out of focus fluorescence background, sample photo-damage and photo-bleaching. However, images acquired with LSFM are often affected by light absorption or scattering effects, leading to un-even illumination and striping artifacts. In this work we present an optical solution to this problem, via fast multi-directional illumination of the sample, based on an acousto-optical deflector (AOD). We demonstr…
Selective Laser Melting of Ti6Al4V: Effects of Heat Accumulation Phenomena Due to Building Orientation
2022
Titanium alloy Ti6Al4V is one of the most utilized alloys in the field of additive manufacturing due to the excellent combination of mechanical properties, density and good corrosion behavior. These characteristics make the use of this material particularly attractive for additively manufacturing components with complex geometry in sectors such as aeronautics and biomedical. Selective Laser Melting (SLM), by which a component is fabricated by selectively melting of stacked layers of powder using a laser beam, is the one of most promising additive manufacturing technologies for Ti6Al4V alloy. Although this technique offers numerous advantages, it has some critical issues related to the high …
Additive manufacturing, new elaboration technique of metallic materials : impact of the microstructure on high temperature durability of AISI 316L st…
2021
Additive Manufacturing (AM) processes are able to elaborate, in a single step, metallic parts with very complex geometry, as close as possible to their final dimensions, based on 3D CAD model. Despite a very large number of studies on AM parameters, very few studies report on the high temperature behavior of the metallic materials produced by these processes. This thesis work evaluates the impact of the Selective Laser Melting (SLM) process on the high temperature durability of the austenitic stainless steel AISI 316L, commercial grade widely used in the industry. For this purpose, the reactivity of SLM samples was studied in different conditions (atmosphere, temperature, isothermal or cycl…
On improving the accuracy of Visible Light Positioning system using deep autoencoder
2020
International audience; DC-biased optical Orthogonal Frequency DivisionMultiplexing (DCO-OFDM)-based visible light positioning (VLP)technology along with the Received Signal Strength(RSS) po-sitioning algorithm is widely used to achieve centimeter levelpositioning accuracy for incoming 5G era, especially indoorenvironment. However, the DCO-OFDM has the peak-to-averagepower ratio (PAPR) issue which imposes the nonlinear distortionand it will directly affect the positioning accuracy in the VLPsystem. The PAPR reduction scheme is urgently needed. There-fore, in this paper, the impact of PAPR reduction scheme onpositioning accuracy is investigated. The positioning accuracywith and without the s…
Influence of temperature on mass transfer in an incomplete trapping single hollow fibre supported liquid membrane extraction of triazole fungicides.
2008
The influence of temperature in a single hollow fibre supported liquid membrane extraction of triazole fungicides with a stagnant acceptor phase was investigated. The mass transfer parameters such as diffusion coefficient, flux and apparent viscosity were determined at temperature ranging from 278 K to 313 K. Increase in temperature led to an increase in diffusion coefficient and flux. The apparent viscosity also decreased with an increase in temperature. The degree of trapping in the acceptor phase influenced the mass transfer at higher temperature. At lower temperature, the transport of analytes from the donor solution through the donor-membrane interface and through the membrane mainly a…
SLMotion - An extensible sign language oriented video analysis tool
2014
We present a software toolkit called SLMotion which provides a framework for automatic and semiautomatic analysis, feature extraction and annotation of individual sign language videos, and which can easily be adapted to batch processing of entire sign language corpora. The program follows a modular design, and exposes a Numpy-compatible Python application programming interface that makes it easy and convenient to extend its functionality through scripting. The program includes support for exporting the annotations in ELAN format. The program is released as free software, and is available for GNU/Linux and MacOS platforms. peerReviewed