Search results for "SMIS"
showing 10 items of 2316 documents
Prevalencia de la enfermedad de Chagas en donantes y en mujeres embarazadas procedentes de Latinoamérica: estudio epidemiológico
2021
El objetivo de la tesis fue conocer la prevalencia de la enfe5rmedad de Chagas en población de riesgo de ambos sexos procedentes de Latinoamérica y la incidencia de la transmisión vertical (Chagas congénito en los bebés nacidos de mujeres diagnosticadas durante el periodo de estudio. Se diseñó un estudio epidemiológico transversal, descriptivo, con dos cohortes poblacionales (donantes de sangre y mujeres embarazadas) y dos fases temporales, una prospectiva (2006-2010) y otra retrospectiva (2011-2015. Los datos demográficos básicos y los resultados sobre el diagnóstico de la enfermedad de Chagas fueron facilitados por los laboratorios de los centros participantes en el estudio (Centro de tra…
Experimental Evolution Reveals a Genetic Basis for Membrane-Associated Virus Release
2021
Many animal viruses replicate and are released from cells in close association to membranes. However, whether this is a passive process or is controlled by the virus remains poorly understood. Importantly, the genetic basis and evolvability of membrane-associated viral shedding have not been investigated. To address this, we performed a directed evolution experiment using coxsackievirus B3, a model enterovirus, in which we repeatedly selected the free-virion or the fast-sedimenting membrane-associated viral subpopulations. The virus responded to this selection regime by reproducibly fixing a series of mutations that altered the extent of membrane-associated viral shedding, as revealed by fu…
Medical masks and Respirators for the Protection of Healthcare Workers from SARS-CoV-2 and other viruses
2020
The use of medical masks and respirators as personal protective equipment is pivotal to reducing the level of biological hazard to which healthcare workers are exposed during the outbreak of highly diffusible pathogens, such as the recent novel coronavirus SARS-CoV-2. Unfortunately, during this pandemic, supplies are rapidly running out worldwide, with potential consequences for the rate of occupational infections. Also, knowledge about specific characteristics of respirators is of utmost importance to select the proper type according to the clinical setting. A wide variety of literature is available on the topic, but mostly based on Influenza viruses infection models. Clinical evidence on …
Occlusion-derived baculovirus: interaction with human cells and evaluation of the envelope protein P74 as a surface display platform.
2008
To develop complementary baculovirus-based tools for gene delivery and display technologies, the interaction of occlusion-derived baculovirus (ODV) with human cells, and the functionality of the P74 ODV envelope protein for display of the IgG-binding Z domains (ZZP74) were evaluated. The cellular binding of ODV was concentration-dependent and saturable. Only minority of the bound virions were internalized at both 37 and 4 degrees C, suggesting usage of direct membrane fusion as the entry mode. The intracellular transport of ODV was confined in vesicular structures peripheral to the plasma membrane, impeding subsequent nuclear entry and transgene expression. Transduction of ODV was not rescu…
Why viruses sometimes disperse in groups?
2019
AbstractMany organisms disperse in groups, yet this process is understudied in viruses. Recent work, however, has uncovered different types of collective infectious units, all of which lead to the joint delivery of multiple viral genome copies to target cells, favoring co-infections. Collective spread of viruses can occur through widely different mechanisms, including virion aggregation driven by specific extracellular components, cloaking inside lipid vesicles, encasement in protein matrices, or binding to cell surfaces. Cell-to-cell viral spread, which allows the transmission of individual virions in a confined environment, is yet another mode of clustered virus dissemination. Nevertheles…
IEEE Access Special Section Editorial: Exploiting the Benefits of Interference in Wireless Networks: Energy Harvesting and Security
2018
Interference used to be viewed as a harmful factor in wireless networks, which can reduce the quality of information transmission. To combat against interference, many interference management techniques have emerged. Due to the latest research advances, interference (or noise) can also be exploited to offer some benefits to wireless networks. The first aspect is that interference in multi-user networks can be collected as a green power supply for the transceivers, known as wireless energy harvesting. Another application is that one can generate artificial noise to disrupt the adversarial eavesdropping, and guarantee the security of wireless networks. Therefore, conventional interference man…
Energy Efficient Optimization for Wireless Virtualized Small Cell Networks With Large-Scale Multiple Antenna
2017
Wireless network virtualization is envisioned as a promising framework to provide efficient and customized services for next-generation wireless networks. In wireless virtualized networks (WVNs), limited radio resources are shared among different services providers for providing services to different users with heterogeneous demands. In this paper, we propose a resource allocation scheme for an orthogonal frequency division multiplexing-based WVN, where one small cell base station equipped with a large number of antennas serves the users with different service requirements. In particular, with the objective to obtain the energy efficiency in the uplink, a joint power, subcarrier, and antenn…
L’oggetto dell’impugnazione nel sistema giuslavoristico delle decadenze oltre il licenziamento
2022
With judgements no. 30490/2021 and no. 40652/2021 the Supreme Court affirmed that if the employee, as part of a contract, claims that the relationship is attributed to another employer, there is no burden of appeal from the cessation of the activity, unless there is a written communication equivalent to a dismissal. The regulations regarding limitation are, in fact, strictly interpreted and are not susceptible of analogous application. The Author examines the two decisions in the light of the overall context of the rules on limitation through an analysis of the jurisprudence of legitimacy and merit, even if not in conformity, to finally clarify that the position taken by the Supreme Court i…
Kulturowa transmisja międzypokoleniowa na przykładzie zabaw i zabawek czterech pokoleń
2017
Zamiarem autora było podkreślenie wagi zabawy i zabawki w przekazywaniu kulturowych treści kolejnym pokoleniom. Niezależnie od losów państwa, biegu historii i różnych sytuacji, których nie da się przewidzieć, w człowieku istnieje potrzeba ciągłości gatunku, rodziny, tradycji, obyczajów, wierzeń i pamiętania o przeszłości. Są takie wzory zabaw oraz zabawek, które towarzyszą ludzkości od najdawniejszych czasów, zyskały miano dziedzictwa kulturowego, stając się znaczącym elementem naszej kultury. Wyniki badań dotyczą różnorodności, preferencji zabaw i zabawek czterech pokoleń, a także funkcji socjalizacyjnej, wpływu na rozwój emocjonalny jednostki oraz przemian owych funkcji, które nastąpiły n…
Phosphorus limitation enhances parasite impact: feedback effects at the population level
2014
Background Nutrient deficiency affects the growth and population dynamics of consumers. Endoparasites can be seen as consumers that drain carbon (C) or energy from their host while simultaneously competing for limiting resources such as phosphorus (P). Depending on the relative demands of the host and the parasite for the limiting nutrient, intensified resource competition under nutrient limitation can either reduce the parasite’s effect on the host or further reduce the fitness of the nutrient-limited host. So far, knowledge of how nutrient limitation affects parasite performance at the host population level and how this affects the host populations is limited. Results We followed the popu…