Search results for "SOCE"

Thalassocella blandensis gen. nov., sp. nov., a novel member of the family Cellvibrionaceae

2020

9 pages, 1 figure, 3 tables

Monitoring campaign over an edible dormouse population (Glis glis; rodentia: Gliridae) in Sicily: First report of mesocestodiasis

2021

Simple Summary In Nebrodi Park (Sicily, Italy), live many wild mammal species that move closer to human beings every day. The edible dormouse (Glis glis), in 2017 and 2018, was responsible for nut crop damage in the area. For this reason, a sanitary monitoring campaign involving 30 dormice was carried out by collecting rectal and conjunctival swabs and fur and nest content, which were then processed for laboratory examinations. A large presence of fleas belonging to Monopsyllus sciurorum was found. Necropsy of a dead dormouse revealed an infection of Mesocestoides lineatus, whose cysts were found in the abdomen cavity and on the liver; this is the first report of this in this species. Furth…

Cestode parasites release extracellular vesicles with microRNAs and immunodiagnostic protein cargo.

2017

Intercellular communication is crucial in multiple aspects of cell biology. This interaction can be mediated by several mechanisms including extracellular vesicle (EV) transfer. EV secretion by parasites has been reported in protozoans, trematodes and nematodes. Here we report that this mechanism is present in three different species of cestodes, Taenia crassiceps, Mesocestoides corti and Echinococcus multilocularis. To confirm this we determined, in vitro, the presence of EVs in culture supernatants by transmission electron microscopy. Interestingly, while T. crassiceps and M. corti metacestodes secrete membranous structures into the culture media, similar vesicles were observed in the int…

First Data on the Helminth Community of the Smallest Living Mammal on Earth, the Etruscan Pygmy Shrew, Suncus etruscus (Savi, 1822) (Eulipotyphla: So…

2021

Suncus etruscus is the smallest living mammal on Earth by mass. Most adults weigh 1.8–3 g with a body length of 35–48 mm. Catching it in small mammal traps in nature is extremely difficult due to its minute size, and therefore special trapping methods must be used. We had the unique opportunity of studying, for the first time, the helminth parasites of 166 individuals of S. etruscus, part of the largest collection in the world, which belonged to the French scientist Dr Roger Fons (1942–2016). A total of 150 individuals were captured in the Banyuls-Cerbère area (France) and 16 in the island of Corsica (France). We found seven helminth species, specifically, the cestodes Joyeuxiella pasqualei…

The plasma membrane channel ORAI1 mediates detrimental calcium influx caused by endogenous oxidative stress.

2013

The mouse hippocampal cell line HT22 is an excellent model for studying the consequences of endogenous oxidative stress. Addition of extracellular glutamate depletes the cells of glutathione (GSH) by blocking the glutamate-cystine antiporter system x(c)(-). GSH is the main antioxidant in neurons and its depletion induces a well-defined program of cell death called oxytosis, which is probably synonymous with the iron-dependent form of non-apoptotic cell death termed ferroptosis. Oxytosis is characterized by an increase of reactive oxygen species and a strong calcium influx preceding cell death. We found a significant reduction in store-operated calcium entry (SOCE) in glutamate-resistant HT2…

SU-E-T-176: Commissiong and Initial Clinical Experience with Dosimetry Check, a Commercial Software for in Vivo Volumetric Dosimetry

2013

Purpose: The aim of this work is to study the differences of reference point doses between the commercial EPID based dosimetry software Dosimetry Check (DC) and TPS to establish an accuracy level of the system, to evaluate its use in clinical routine and to obtain results for the first patients. Methods: We used DC v.3.8 (Math Resolutions), two Varian Clinac iX accelerators equipped with EPID aS1000 and Eclipse v.10.0 with AAA algorithm. Several plans with and without air gap were generated over the phantoms: MP1 Water Tank and Solid Octavius 4D (PTW). 5 head and neck, 3 lung and 4 prostate cases were selected for clinical evaluation. We compared the calculated dose at the isocenter and in …

SU-E-J-69: Evaluation of the Lens Dose On the Cone Beam IGRT Procedures

2014

Purpose: With the establishment of the IGRT as a standard technique, the extra dose that is given to the patients should be taken into account. Furthermore, it has been a recent decrease of the dose threshold in the lens, reduced to 0.5 Gy (ICRP ref 4825-3093-1464 on 21st April, 2011).The purpose of this work was to evaluate the extra dose that the lens is receive due to the Cone-Beam (CBCT) location systems in Head-and-Neck treatments. Methods: The On-Board Imaging (OBI) v 1.5 of the two Varian accelerators, one Clinac iX and one True Beam, were used to obtain the dose that this OBI version give to the lens in the Head-and-Neck location treatments. All CBCT scans were acquired with the Sta…

LE VERITÀ REGOLARI. L’EIKOS NELLA MEDICINA IPPOCRATICA

2012

Short report - A new case report of human Mesocestoides infection in the United States

2003

The twenty-seventh documented case of human Mesocestoides infection, which corresponds to the seventh documented case in the United States, is reported. The case had its origin in Alexandria, Louisiana in the summer of 1998. The patient was a 19-month-old boy. The strobila consisted of 35 proglottids that included mature as well as gravid segments containing a ventral genital pore and a parauterine organ. After a detailed microscopic examination, the tapeworm was identified as belonging to the genus Mesocestoides. Mesocestoides variabilis is the probable species responsible for the infection, since the six cases previously reported in the United States were identified as this species. After…

Patient centring and scan length: how inaccurate practice impacts on radiation dose in CT colonography (CTC).

2019

Objective: The aim of this study was to acknowledge errors in patients positioning in CT colonography (CTC) and their effect in radiation exposure. Materials and methods: CTC studies of a total of 199 patients coming from two different referral hospitals were retrospectively reviewed. Two parameters have been considered for the analysis: patient position in relation to gantry isocentre and scan length related to the area of interest. CTDI vol and DLP were extracted for each patient. In order to evaluate the estimated effective total dose and the dose to various organs, we used the CT-EXPO ® software version 2.2. This software provides estimates of effective dose and doses to the other vario…