Search results for "SOCIAL STRESS"
showing 10 items of 138 documents
Resilience to social stress effects: depression and cocaine reward
2020
Poster presentado al congreso socidrogalcol 2020 PSI2017-83023
Characterization and enhancement of resilience to the effects of social stress on the rewarding properties of cocaine in male mice
2022
El principal foco de interés en la presente Tesis Doctoral es estudiar la resiliencia a desarrollar un trastorno por consumo de cocaína tras la exposición a estrés. Para ello utilizamos modelos animales de estrés social (la derrota social repetida intermitente, DSRI) y de efectos reforzantes de las drogas (el paradigma de Condicionamiento de Preferencia de Lugar, CPL), ya que en estudios previos hemos demostrado que la exposición a DSRI incrementa los efectos reforzantes de la cocaína en el CPL (García-Pardo y cols., 2019; Calpe-López y cols., 2020). Nuestro objetivo es identificar a los animales resilientes a este efecto de la DSRI, caracterizar su comportamiento tras el estrés, estudiar s…
Oxytocin Signaling as a Target to Block Social Defeat-Induced Increases in Drug Abuse Reward
2021
There is huge scientific interest in the neuropeptide oxytocin (OXT) due to its putative capacity to modulate a wide spectrum of physiological and cognitive processes including motivation, learning, emotion, and the stress response. The present review seeks to increase the understanding of the role of OXT in an individual’s vulnerability or resilience with regard to developing a substance use disorder. It places specific attention on the role of social stress as a risk factor of addiction, and explores the hypothesis that OXT constitutes a homeostatic response to stress that buffers against its negative impact. For this purpose, the review summarizes preclinical and clinical literature rega…
Hormonal responsiveness in the Trier Social Stress Test and the dexamethasone‐corticotropin releasing hormone test in healthy individuals
2021
A number of different laboratory procedures investigate the hormonal response in a standardized pharmacological challenge test (dexamethasone-corticotropin releasing hormone; DEX-CRH) or in a psychosocial stress induction on the hypothalamic-pituitary-adrenocortical axis by the Trier Social Stress Test (TSST). However, the magnitude of the response related to the different stressors and the interaction of the responsiveness between the two tests is still unclear. Fifty-two participants underwent both the DEX-CRH test and the TSST on two separate days. The cortisol and the plasma adrenocorticotropic hormone (ACTH) release were assessed before and after the stress tests. For a specification o…
Resilience to social defeat-induced increased in ethanol intake: neuroinflammation response
2022
El estrés social es el principal factor de riesgo de las conductas adictivas. El fenotipo susceptible al estrés se ha convertido en la última década en un objetivo de estudio para la aplicación de tratamientos eficaces que mejoren la resiliencia al estrés. La promoción del afrontamiento activo mediante intervenciones farmacológicas y ambientales positivas está científicamente validada en el tratamiento de las adicciones. Sin embargo, estas intervenciones para promover la resiliencia durante la adolescencia como medida preventiva de experiencias estresantes intensas durante la edad adulta no han sido ampliamente estudiadas. Por ello, el objetivo principal de la presente Tesis Doctoral fue de…
The Role of Spatial Exploration and Territoriality in Establishing Gilthead Seabream (Sparus aurata) Hierarchies, and Their Effects upon Underlying S…
2023
Territoriality, spatial exploration and social hierarchy are strictly related behaviors in gregarious fishes, and are often under-appreciated in farms where the individuals are confined within crowded spaces. In this study, we investigated the role of spatial exploration, elucidating the importance of time upon forming the social organization, and the role of the territoriality in gilthead seabream (Sparus aurata), using two experimental approaches. In the first approach, three fish were placed sequentially in the aquarium with an interval of two days (sequential model), while in the second (simultaneous model), two fish were simultaneously placed in an aquarium divided by a barrier which w…
High testosterone levels and sensitivity to acute stress in perpetrators of domestic violence with low cognitive flexibility and impairments in their…
2013
Hormonal and neuropsychological impairment in intimate partner violence (IPV) perpetrators could play a role in domestic violence. For characterizing whether there is a specific psychobiological response to stress, participants who had previously been jailed for IPV and controls were compared for testosterone and cortisol levels, tested for 2D:4D ratio (as an indicator of masculinization), and given several trait questionnaires and neuropsychological tests related to executive functions and theory of mind. After performing the Trier Social Stress Test (TSST), IPV perpetrators experienced decreases in salivary testosterone (T) levels, a moderate worsening of mood, slight anxiety, and a saliv…
Effects of Chronic Social Defeat Stress on Behavior and Dopamine Receptors in Adolescent Mice With 6-Hydroxydopamine Lesions of the Medial Prefrontal…
2021
Background: Social stress factors in schizophrenia have long-term effects, but will only induce symptoms in a portion of individuals, even if exposed to identical stress.Methods: In the current experiment, we examined mice with 6-hydroxydopamine (6-OHDA)-induced medial prefrontal cortical (mPFC) injury to select for members of a “stress-susceptible group,” and observed the changes in their behavior and the expression of D1 and D2 dopamine receptors in the amygdala and hippocampus.Results: We observed that after chronic social defeat stress, 72.6% of the 6-OHDA lesioned mice exhibited stress response to aggressors, compared to 52.3% of the blank control group. Both the 6-OHDA lesion + social…
Effects of Fasting and Glucose Load on Free Cortisol Responses to Stress and Nicotine1
1997
The availability of energy appears to exert important regulatory functions in pituitary-adrenal stress responses. In two studies, the effects of short-term fasting and subsequent glucose administration on the free cortisol response to psychological stress and nicotine consumption were investigated. Study 1: After fasting for 8-11 h, healthy young men ingested either 100 g glucose (n = 13) or water (n = 12). One hour later they were exposed to a psychosocial stress task (Trier Social Stress Test). A third group also ingested 100 g glucose, but they were not exposed to any additional treatment (n = 10). Capillary blood glucose levels were in the lower euglycemic range before and significantly…
Seabream (Sparus aurata) long-term dominant-subordinate interplay affects phagocytosis by peritoneal cavity cells.
2012
Fish are sensitive to stressful conditions that affect their innate immune systems and increase their susceptibility to diseases. We examined the social stress of paired gilthead seabream (Sparus aurata). Social hierarchies (dominant/subordinate) were characterised by behavioural changes, such as “aggressiveness” and “feeding order”; hierarchical positions were established within an hour of exposure to social stress and remained unchanged for approximately 1 year. To characterise physiological stress, we measured blood plasma levels of cortisol, glucose, and lactate as well as osmolarity and observed that the levels of these stress markers were higher in subordinate individuals than in domi…