Search results for "SOD"
showing 10 items of 2830 documents
Current and birth weights exert independent influences on nocturnal pressure-natriuresis relationships in normotensive children
1998
The objective was to study the impact of birth weight on the relationship between ambulatory blood pressure and urinary sodium excretion in children and adolescents. The study included 134 healthy children (61 boys), all Caucasians, who were born at term after a normotensive pregnancy. For each subject, a 24-hour ambulatory blood pressure monitoring and a complete urine collection were simultaneously performed according to the protocols designed. Average ambulatory blood pressure (BP) and the urinary excretion rates for sodium, potassium, and creatinine were calculated separately for 24-hour, awake, and sleep periods defined by a mini-diary. The excretion rate of sodium during sleep time wa…
Emisiones difusas: medidas experimentales y modelización aplicadas a instalaciones de tratamiento de aguas residuales
2015
Los olores emitidos por la actividad rutinaria de una planta de tratamiento de aguas residuales (EDAR) representan una importante fuente de molestia medioambiental que, por lo general, implica la liberación atmosférica de sustancias que causan mal olor y problemas de salud asociados. Actualmente, existe una preocupación pública sobre los olores que se generan con trabajos de tratamiento de residuos. Esta preocupación ha aumentado en la última década debido principalmente a la sobrecarga en las zonas de captación y la invasión de núcleos habitados en torno a instalaciones de tratamiento de aguas residuales (reduciendo los márgenes de seguridad impuestos a éstos). Estas potenciales emisiones …
Criterios de selección y caracterización de episodios de lluvia. Aplicación a la Confederación Hidrográfica del Júcar (1989-2003)
2006
El análisis espacio-temporal de la lluvia precisa de la identificación de episodios, en función del objetivo de la investigación y la escala de trabajo. En esta comunicación se proponen criterios de selección de episodios, con objetivos hidrológicos, y se aplican al territorio de la Confederación Hidrográfica del Júcar, en base a los datos diarios de 15 años (1989-2003), proporcionados por el Sistema Automático de Información Hidrológica. Se seleccionan 363 episodios y se caracterizan en base a indicadores de total, duración, intensidad e irregularidad, calculados en once unidades territoriales. El análisis de estos indicadores evidencia una dicotomía litoral-interior. El ámbito litoral (ex…
José María Ponsoda Bravo y la imagen escultórica religiosa de su tiempo en Valencia
2017
La presente tesis se centra en el estudio de la vida y la obra del escultor José María Ponsoda Bravo (Barcelona, 1882-Valencia, 1963), en el contexto de la imaginería valenciana de su tiempo. Valorado y apreciado en su tiempo como uno de los mejores imagineros valencianos, a raíz de su muerte, la figura de José María Ponsoda cayó en el olvido, percibiéndose un proceso de recuperación de su nombre desde los años noventa coincidiendo con el interés por la escultura en madera policromada. Juntamente con Barcelona, Valencia detentó un papel hegemónico como centro productor de imaginería con respecto a otros centros peninsulares, desde el segundo tercio del siglo XIX, como el número de obradores…
Religious-Philosophical Articles, XXXIII
2022
Žurnāla “Reliģiski-filozofiski raksti” XXXIII laidiens veltīts Latvijas sabiedrības vērtību analīzei salīdzinošā perspektīvā. Ņemot vērā vērtību jēdziena daudzdimensionālo raksturu, vērtību apraksts, analīze un klasifikācija visos laikos ir izraisījusi diskusijas, strīdus un pat konfliktus. Ideja veidot speciālu žurnāla numuru nolūkā veicināt teorētisko un empīrisko zināšanu attīstību par vērtībām Latvijā, aicinot sociālo un humanitāro zinātņu pētniekus dalīties ar jaunākajiem pētījumiem un atziņām šajā jomā, dzima projekta “Vērtību maiņa nestabilos apstākļos: sabiedrības saliedētība un neoliberālais ētoss” īstenošanas laikā. Pētnieciskā projekta tiešais mērķis bija sniegt jaunu salīdzinošu…
Canagliflozin and Renal Events in Diabetes with Established Nephropathy Clinical Evaluation and Study of Diabetic Nephropathy with Atrasentan : what …
2019
Albuminuria; Atrasentan; Canagliflozin Albuminuria; Atrasentan; Canagliflozina Albuminúria; Atrasentan; Canagliflozina In April 2019, two major Phase 3 randomized clinical trials were published that assessed primary renal outcomes in diabetic kidney disease (DKD) in type 2 diabetes mellitus (T2DM). The Canagliflozin and Renal Events in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE) tested an already available antidiabetic drug, canagliflozin, and the Study of Diabetic Nephropathy with Atrasentan (SONAR) tested a novel molecule, the endothelin-1 receptor blocker atrasentan, both on top of renin-angiotensin system blockade. Both trials demonstrated significant nephroprot…
Polyoxypregnanes as safe, potent, and specific ABCB1-inhibitory pro-drugs to overcome multidrug resistance in cancer chemotherapy in vitro and in vivo
2021
Multidrug resistance (MDR) mediated by ATP binding cassette subfamily B member 1 (ABCB1) is significantly hindering effective cancer chemotherapy. However, currently, no ABCB1-inhibitory drugs have been approved to treat MDR cancer clinically, mainly due to the inhibitor specificity, toxicity, and drug interactions. Here, we reported that three polyoxypregnanes (POPs) as the most abundant constituents of Marsdenia tenacissima (M. tenacissima) were novel ABCB1-modulatory pro-drugs, which underwent intestinal microbiota-mediated biotransformation in vivo to generate active metabolites. The metabolites at non-toxic concentrations restored chemosensitivity in ABCB1-overexpressing cancer cells v…
Quantification of atelectatic lung volumes in two different porcine models of ARDS.
2006
BACKGROUND: Cyclic recruitment during mechanical ventilation contributes to ventilator associated lung injury. Two different pathomechanisms in acute respiratory distress syndrome (ARDS) are currently discussed: alveolar collapse vs persistent flooding of small airways and alveoli. We compare two different ARDS animal models by computed tomography (CT) to describe different recruitment and derecruitment mechanisms at different airway pressures: (i) lavage-ARDS, favouring alveolar collapse by surfactant depletion; and (ii) oleic acid ARDS, favouring alveolar flooding by capillary leakage. METHODS: In 12 pigs [25 (1) kg], ARDS was randomly induced, either by saline lung lavage or oleic acid (…
Elektrophysiologische Untersuchung zum Einsatz von Streptolysin O und Natrium-Hyaluronat zur Permeabilitätsmodulation der Membran des runden Fensters…
2003
Background: The round window membrane (RWM) acts like a barrier for topically applied substances into the middle ear preventing diffusion into the perilymphatic fluid compartment. Material and Method: In an animal model, modulation of the permeability of the RWM was attempted using Streptolysin-O (SLO) in various concentrations and sodium hyaluronate. Thereafter, the effect of intratympanically applied Lidocain 2% on hearing threshold measured by auditory brainstem response was tested for Lidocain 2 % and Lidocain 2 % in combination with SLO or sodium hyaluronate. Results: The results show that both, SLO and sodium hyaluronate, influence the effect of Lidocain 2 % on hearing thresholds as a…
Hybrid layers of etch-and-rinse versus self-etching adhesive systems.
2010
Objective: To evaluate the effectiveness in the formation of resin tags, adhesive lateral branches and hybrid layers of five adhesive systems, when bonding to dentine. Material and Methods: Flat dentin surfaces from 25 molars were bonded with several adhesive systems according to the manufacturers? instructions. Composite build-ups were constructed incrementally with Tetric Ceram. The Specimens were sectioned parallel to the long axis. One section was treated with phosphoric acid and sodium hypochlorite in order to reveal the hybrid layer formation. The other section was stored in 30% hydrochloric acid to detect resin tags and adhesive lateral branch formation. Results: The two etch-and-rin…