Search results for "SPIONs"

showing 2 items of 12 documents

Ferritin-Coated SPIONs as New Cancer Cell Targeted Magnetic Nanocarrier

2023

Superparamagnetic iron oxide nanoparticles (SPIONs) may act as an excellent theragnostic tool if properly coated and stabilized in a biological environment, even more, if they have targeting properties towards a specific cellular target. Humanized Archaeoglobus fulgidus Ferritin (HumAfFt) is an engineered ferritin characterized by the peculiar salt-triggered assembly-disassembly of the hyperthermophile Archaeoglobus fulgidus ferritin and is successfully endowed with the human H homopolymer recognition sequence by the transferrin receptor (TfR1 or CD71), overexpressed in many cancer cells in response to the increased demand of iron. For this reason, HumAfFt was successfully used in this stud…

nanoparticleferritinOrganic ChemistrySPIONcoatingPharmaceutical ScienceSPIONs; cancer cell targeting; coating; ferritin; nanoparticlesAnalytical Chemistrycancer cell targetingSPIONsChemistry (miscellaneous)Drug DiscoveryMolecular MedicinenanoparticlesPhysical and Theoretical ChemistryMolecules
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Nanosystem for diagnosis and photothermal treatment of tumors

2022

The invention relates to a nanosystem for the diagnosis, image-guided treatment of tumors and monitoring of the tumor microenvironment. The nanosystem is a contrast agent comprising a polymer shell based on a hyaluronic acid nanogel, super-parameg-netic iron oxide nanoparticles (SPIONs) and carbon nanoparticles (CDs).

theranostics nanomedicine MRI photo thermal therapy SPIONs hyaluronic acid
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