Search results for "SPS"
showing 10 items of 2517 documents
The neurochaperonopathies: Anomalies of the chaperone system with pathogenic effects in neurodegenerative and neuromuscular disorders
2021
The chaperone (or chaperoning) system (CS) constitutes molecular chaperones, co-chaperones, and chaperone co-factors, interactors and receptors, and its canonical role is protein quality control. A malfunction of the CS may cause diseases, known as the chaperonopathies. These are caused by qualitatively and/or quantitatively abnormal molecular chaperones. Since the CS is ubiquitous, chaperonopathies are systemic, affecting various tissues and organs, playing an etiologic-pathogenic role in diverse conditions. In this review, we focus on chaperonopathies involved in the pathogenic mechanisms of diseases of the central and peripheral nervous systems: the neurochaperonopathies (NCPs). Genetic …
Exosomal Chaperones and miRNAs in Gliomagenesis: State-of-Art and Theranostics Perspectives
2018
Gliomas have poor prognosis no matter the treatment applied, remaining an unmet clinical need. As background for a substantial change in this situation, this review will focus on the following points: (i) the steady progress in establishing the role of molecular chaperones in carcinogenesis; (ii) the recent advances in the knowledge of miRNAs in regulating gene expression, including genes involved in carcinogenesis and genes encoding chaperones; and (iii) the findings about exosomes and their cargo released by tumor cells. We would like to trigger a discussion about the involvement of exosomal chaperones and miRNAs in gliomagenesis. Chaperones may be either targets for therapy, due to their…
Assessment of genetically modified sugar beet H7‐1 for renewal of authorisation under Regulation (EC) No 1829/2003 (application EFSA‐GMO‐RX‐006)
2017
Efsa Panel On Genetically Modified Organisms (gmo)Scientific opinionRequestor: European Commission (DG SANTE)Question number: EFSA-Q-2017-00026; Following the submission of application EFSA-GMO-RX-006 under Regulation (EC) No 1829/2003 fromKWS SAAT SE and Monsanto Company, the Panel on Genetically Modified Organisms of the EuropeanFood Safety Authority (GMO Panel) was asked to deliver a scientific risk assessment on the datasubmitted in the context of the renewal of authorisation application for the herbicide-tolerantgenetically modified sugar beet H7-1. The data received in the context of this renewal applicationcontained a systematic search and evaluation of literature, updated bioinforma…
“Minding the gap” in the research on human trafficking for sexual purposes
2017
Since the signature of the United Nations Trafficking Protocol in December 2000 that human trafficking has been labelled as a transnational, complex criminal phenomenon. However, despite the implementation of international soft law instruments to tackle the phenomenon, human trafficking is constantly evolving by the frequent changes of strategies, routes, types of exploitation and methodologies applied by the criminal networks. This flexibility of the phenomenon does not only difficult the implementation of effective tackling measures, but it also demonstrates to be an obstacle to produce accurate information on the subject (Cusick et al, 2009). Furthermore, due to the hidden nature of the …
Acceptance and Commitment Therapy for Health Behavior Change: A Contextually-Driven Approach.
2018
Promoting health behavior change presents an important challenge to theory and research in the field of health psychology. In this paper, we introduce a context-driven approach, the Acceptance and Commitment Therapy (ACT) model which is built on Relational Frame Theory. The ACT-based intervention aims to promote individuals’ new health behavior patterns through the improvement of the key construct of psychological flexibility, which is defined as the ability to contact the present moment more fully with acceptance and mindfulness as a conscious human being. Building on the psychological flexibility model, implemented through the six core ACT processes, individuals improve maintenance of lon…
I contratti di rete: valutazioni oltre l'emergenza
2018
The network contract: some evaluations after the emergency. The debate over the Italian network contract develops in the phase of the heaviest crisis for Italians firms. This article evaluates limits and opportunities of network contracts. Findings are based on 14 network cases selected among declining or growing productive sectors in the context of two regions of the South: Apulia and Sicily. Formal networks, although initiated later than in the Northern regions, are indeed now widespread also in the South. The main findings concern the inability of formal networks to support actors to come out of the crisis. Actually, the decline of the sector is one of the most relevant factors that can …
Mafia Methods, Extortion Dynamics and Social Responses
2016
This chapter is devoted to exploring both the empirical results and the policy proposals produced by the GLODERS project. Based on 631 cases of extortions, the Sicily and Calabria extortion database represents a relevant achievement in the field of the research on extortion racket and it is one of the main results of the GLODERS project. Gathering a great amount of information, our empirical analysis revealed the existence of several differences in the extortive conducts carried on within these two regions, which are presented. Moreover, the chapter introduces the legislation related to the crime of extortion. Social and legal responses to the phenomenon are then discussed.
Dal 15M al 24M: il maggio spagnolo da Democracia Real Ya (DRY) a Podemos
2015
Gli elementi che indignarono gli aderenti al movimento del 15M erano connessi alla politica dettata dall’austerity, alla disoccupazione record, alla precarizzazione dei giovani con l’incremento dei contratti a termine, alle misure di ristrutturazione e riduzione dello Stato sociale, attuate allora dal Governo Zapatero su pressione di BCE e FMI, e appoggiate dal Partito Popolare. Un forte sdegno investiva inoltre una classe politica percepita come altamente corrotta in un Paese in crisi (nel 2009 – c’erano stati ben 730 processi pendenti a carico di amministratori pubblici, con il primato del PSOE con 264 casi di corruzione aperti, seguito dai 200 casi del PP). Già nel giugno 2011 si assiste…
Bagheria e l’amministrazione Cinque Stelle (Bagheria and Five Star local government)
2016
Il paper studierà il caso di Bagheria in provincia di Palermo, Comune amministrato da Patrizio Cinque sindaco del Movimento 5 Stelle da giugno 2014. A partire dall’analisi degli elementi che ne hanno contribuito a determinare il successo elettorale (connessi allo scenario e alla campagna elettorale), si prenderanno in considerazione le peculiarità dell’amministrazione locale pentastellata nei suoi primi due anni, approfondendo in particolare la relazione tra portavoce, attivisti ed elettori prima e durante il mandato, i rapporti con gli altri Meetup locali e nazionali, le strategie comunicative, i progetti, la capacità di resistenza agli scandali che hanno colpito l’assessore all’urbanistic…
Social suffering as structural and symbolic violence. LGBT experiences in the Face of AIDS film archive
2018
The chapter aims to summarize the main sociological approaches that acknowledge the link that exists between AIDS and the stigmatization of nonnormative sexual conducts and then we will address the issue of structural violence and how it can be discerned in the impact of HIV/AIDS on oppressed and marginalized groups on a global scale, as manifested in the Face of AIDS film archive.