Search results for "SSA"

Stratégies politiques et médiatiques dans la gestion de la post-crise catalane de 2017

2021

International audience

Mutant HRAS as novel target for MEK and mTOR inhibitors.

2015

HRAS is a frequently mutated oncogene in cancer. However, mutant HRAS as drug target has not been investigated so far. Here, we show that mutant HRAS hyperactivates the RAS and the mTOR pathway in various cancer cell lines including lung, bladder and esophageal cancer. HRAS mutation sensitized toward growth inhibition by the MEK inhibitors AZD6244, MEK162 and PD0325901. Further, we found that MEK inhibitors induce apoptosis in mutant HRAS cell lines but not in cell lines lacking RAS mutations. In addition, knockdown of HRAS by siRNA blocked cell growth in mutant HRAS cell lines. Inhibition of the PI3K pathway alone or in combination with MEK inhibitors did not alter signaling nor had an imp…

A linguistic limbo : migrants' perspectives and attitudes to the roles of English and Finnish in Finnish academic working life

2013

Tämän tutkielman tavoitteena on lisätä ymmärrystä siitä, millaisena suomalaisessa yliopistossa työskentelevät maahanmuuttajat kokevat suomen ja englannin kielen roolit suomalaisessa akateemisessa työelämässä. Tutkielma pyrkii selvittämään näiden kielten käyttöön liittyviä asenteita ja kuvaamaan missä konteksteissa niitä käytetään. Tutkielma nostaa myös esiin tilanteeseen liittyviä positiivisia ilmiöitä sekä mahdollisia haasteita. Tutkimus on laadullinen. Tutkimusaineisto kerättiin teemahaastattelujen avulla. Haastateltavia oli kuusi, ja heistä kaksi puhui äidinkielenään englantia. Haastattelut analysoitiin sisällönanalyysia käyttäen. Tutkimustulokset paljastivat, että haasteltavien näkemyks…

Brain Functional Effects of Psychopharmacological Treatment in Major Depression: A Focus on Neural Circuitry of Affective Processing

2015

In the last two decades, neuroimaging research has reached a much deeper understanding of the neurobiological underpinnings of major depression (MD) and has converged on functional alterations in limbic and prefrontal neural networks, which are mainly linked to altered emotional processing observed in MD patients. To date, a considerable number of studies have sought to investigate how these neural networks change with pharmacological antidepressant treatment. In the current review, we therefore discuss results from a) pharmacological functional magnetic resonance imaging (fMRI) studies investigating the effects of selective serotonin or noradrenalin reuptake inhibitors on neural activation…

the role of antidepressant treatments on cognitive deficits: a review of recent literature

2011

Objective: Nowadays, the interaction between cognition and emotions during a depressive disorder in an area of interest in the scientific literature. Patients with major depressive disorder (MDD) usually show alterations in various cognitive functions: attention, working memory, mental processing speed, executive functions. Clinical observation of the effects of cognitive deficits on quality of life in patients with MDD, in euthymic and relapse phases, needs a review of recent scientific literature on the impact of antidepressant treatment as a protective factor of the improvement of cognitive performances. Methods: Electronic PubMed and PsycInfo searches were conducted to identify research…

Le malentendu : un questionnement

2013

Le Breton David, Profita Gabriele. Le malentendu : un questionnement. In: Revue des sciences sociales, N°50, 2013. Malentendus. pp. 8-13.

Detailed modeling of the kraft pulping chemistry : carbohydrate reactions

2020

The article introduces a detailed model for carbohydrate chemistry in kraft pulping. This article is continuation to the modeling work carried out for hot water extraction and chemical pulp bleaching. The model includes galactoglucomannan, xylan, and cellulose acid–base equilibria, in addition to peeling, stopping, and alkaline hydrolysis reactions of the same carbohydrates, as well as hexenuronic acid formation and degradation reactions. The Arrhenius parameters were applied from the literature or regressed against experimental data in the present study. The model is very successful in predicting the experimental data of carbohydrate reactions during kraft pulping. Many features of the pul…

Modeling biomass char gasification kinetics for improving prediction of carbon conversion in a fluidized bed gasifier

2014

Gasification of biomass in a fluidized bed (FB) was modeled based on kinetic data obtained from previously conducted thermo- gravimetic analysis. The thermogravimetric analysis experiments were designed to closely resemble conditions in a real FB gasifier by using high sample heating rates, in situ devolatilization and gas atmospheres of H 2 O / H 2 and CO 2 / CO mixtures. Several char kinetic models were evaluated based on their ability to predict char conversion based on the thermogravimetric data. A modified version of the random pore model was shown to provide good fitting of the char reactivity and suitability for use in a reactor model. An updated FB reactor model which incorporates t…

Analysis of stability of axially moving orthotropic membranes and plates with a linear non-homogeneous tension profile

2011

Comparison of methods to model species habitat networks for decision-making in nature conservation : the case of the wildcat in southern Belgium

2020

Facing the loss of biodiversity caused by landscape fragmentation, implementation of ecological networks to connect habitats is an important biodiversity conservation issue. It is necessary to develop easily reproducible methods to identify and prioritize actions to maintain or restore ecological corridors. To date, several competing methods are used with recurrent debate on which is best and if expert-based approaches can replace data-driven models. We compared three methods: knowledge-driven (expert based), data-driven (based on species distribution model), and a mixed approach. We quantified their differences in habitat and corridor mapping, and prioritizations of landscape elements in t…