Search results for "SSIBL"

Admissible perturbations of alpha-psi-pseudocontractive operators: convergence theorems

2015

In the last decades, the study of convergence of fixed point iterative methods has received an increasing attention, due to their performance as tools for solving numerical problems. As a consequence of this fact, one can access to a wide literature on iterative schemes involving different types of operators; see [2, 4, 5]. We point out that fixed point iterative approximation methods have been largely applied in dealing with stability and convergence problems; see [1, 6]. In particular, we refer to various control and optimization questions arising in pure and applied sciences involving dynamical systems, where the problem in study can be easily arranged as a fixed point problem. Then, we …

Design and analysis of discrete choice experiments for models with response time

2013

Travelling with disability, welcoming disability. Destination management for accessible tourism

2010

A flux-split algorithm applied to conservative models for multicomponent compressible flows

2003

In this paper we consider a conservative extension of the Euler equations for gas dynamics to describe a two-component compressible flow in Cartesian coordinates. It is well known that classical shock-capturing schemes applied to conservative models are oscillatory near the interface between the two gases. Several authors have addressed this problem proposing either a primitive consistent algorithm [J. Comput. Phys. 112 (1994) 31] or Lagrangian ingredients (Ghost Fluid Method by Fedkiw et al. [J. Comput. Phys. 152 (1999) 452] and [J. Comput. Phys. 169 (2001) 594]). We solve directly this conservative model by a flux-split algorithm, due to the first author (see [J. Comput. Phys. 125 (1996) …

The Right to Legal Assistance in Criminal Proceedings

2021

Hybrid equilibrium element with high-order stress fields for accurate elastic dynamic analysis

2021

In the present article the two-dimensional hybrid equilibrium element formulation is initially developed, with quadratic, cubic, and quartic stress fields, for static analysis of compressible and quasi-incompressible elastic solids in the variational framework of the minimum complementary energy principle. Thereafter, the high-order hybrid equilibrium formulation is developed for dynamic analysis of elastic solids in the variational framework of the Toupin principle, which is the complementary form of the Hamilton principle. The Newmark time integration scheme is introduced for discretization of the stress fields in the time domain and dynamic analysis of both the compressible solid and qua…

The solvent-excluding surface as a descriptor of ionic channels: Gramicidin-A

1998

Abstract We have set out a methodology for checking the performance of the methods used to compute the Solvent-Excluding Surface. The method consists of computing the area of the Solvent-Excluding Surface of a model of channel, with a fixed pore size, for several values of the solvent radius. The graphical representation of the value of the area versus the radius of the solvent sphere shows a sharp change just at the radius of the pore. With this model we may analyze the ability of each method to describe small changes of the surface. We made the study with GEPOL93, older versions of GEPOL and MSDOT. The study is applied to a natural protein channel, as is Gramicidin-A, showing that this ty…

GEPOL: An improved description of molecular surfaces. III. A new algorithm for the computation of a solvent-excluding surface

1994

To understand and calculate the interactions of a solute with a solvent, a good method of computing the molecular surface is needed. Three kinds of surfaces may be used: the van der Waals Surface, the Accessible Surface, and the Molecular Surface. The latter is redefined in this article as the Solvent-Excluding Surface. The new algorithm for computing the Solvent-Excluding Surface included in the GEPOL93 program is described. GEPOL93 follows the same concept as former versions of GEPOL but with a full new algorithm. Thus, it computes the Solvent-Excluding Surface by filling the spaces not accessible to the solvent with a set of new spheres. The computation is controlled by three parameters:…

Determinants essential for the transmissible gastroenteritis virus-receptor interaction reside within a domain of aminopeptidase-N that is distinct f…

1994

The swine-specific coronavirus transmissible gastroenteritis virus (TGEV) uses pig aminopeptidase-N (pAPN) as a cellular receptor. We showed that the human aminopeptidase-N (hAPN) cannot substitute for pAPN in this respect, although the two enzymes have 80% amino acid sequence identity. In order to map the TGEV binding site on pAPN, we constructed a series of APN cDNA chimeras between pAPN and hAPN and analyzed them for their capacity to confer infectivity. The region between residues 717 and 813 was found to be essential for infectivity. This region also contains the epitopes for three TGEV-blocking monoclonal antibodies directed against pAPN. These data support the view that the catalytic…

Molecular study of porcine transmissible gastroenteritis virus after serial animal passages revealed point mutations in S protein

2010

Porcine respiratory coronavirus is related genetically to porcine transmissible gastroenteritis virus with a large deletion in S protein. The respiratory virus is a mutated form that may be a consequence of the gastroen- teritis virus's evolution. Intensive passages of the virus in its natural host may enhance the appearance of mutations and therefore may contribute to any attenuated form of the virus. The objective of this study was to characterize the porcine transmissible gastroenteritis virus TMK22 strain after passages in piglets from 1992 until 2007. A typical experimental infection, molecular characterization, and serological analysis were also carried out to further char- acterize a…