Search results for "SSTA"
showing 10 items of 105 documents
The triad hsp60-mirnas-extracellular vesicles in brain tumors: Assessing its components for understanding tumorigenesis and monitoring patients
2021
Brain tumors have a poor prognosis and progress must be made for developing efficacious treatments, but for this to occur their biology and interaction with the host must be elucidated beyond current knowledge. What has been learned from other tumors may be applied to study brain tumors, for example, the role of Hsp60, miRNAs, and extracellular vesicles (EVs) in the mechanisms of cell proliferation and dissemination, and resistance to immune attack and anticancer drugs. It has been established that Hsp60 increases in cancer cells, in which it occurs not only in the mitochondria but also in the cytosol and plasma-cell membrane and it is released in EVs into the extracellular space and in cir…
Myeloid dendritic cell: From sentinel of immunity to key player of peripheral tolerance?
2009
Myeloid dendritic cells (DC) are "sentinels" of immunity, ideally positioned throughout the body gateways and equipped with unique properties to transport antigens from the periphery to lymphoid tissues. They are professional antigen-presenting cells transmitting incoming infectious signals to T cells, the key players of adaptive immunity. For induction of effective antigen-specific T-cell immunity, crosstalk of DC and naive T cells is mandatory. However, besides this essential immunostimulatory function of DC, consolidated findings from the DC research field in the last 10 years have shown that DC have an additional important function. They act as pivotal players in the peripheral toleranc…
Early life adversity targets the transcriptional signature of hippocampal NG2+ glia and affects voltage gated sodium (Nav) channels properties
2021
The precise mechanisms underlying the detrimental effects of early life adversity (ELA) on adult mental health remain still elusive. To date, most studies have exclusively targeted neuronal populations and not considered neuron-glia crosstalk as a crucially important element for the integrity of stress-related brain function. Here, we have investigated the impact of ELA, in the form of a limited bedding and nesting material (LBN) paradigm, on a glial subpopulation with unique properties in brain homeostasis, the NG2+ cells. First, we have established a link between maternal behavior, activation of the offspring's stress response and heterogeneity in the outcome to LBN manipulation. We furth…
The Crosstalk Between Signaling Pathways and Cancer Metabolism in Colorectal Cancer.
2021
Colorectal cancer (CRC) is one of the most frequently diagnosed cancers worldwide. Metabolic reprogramming represents an important cancer hallmark in CRC. Reprogramming core metabolic pathways in cancer cells, such as glycolysis, glutaminolysis, oxidative phosphorylation, and lipid metabolism, is essential to increase energy production and biosynthesis of precursors required to support tumor initiation and progression. Accumulating evidence demonstrates that activation of oncogenes and loss of tumor suppressor genes regulate metabolic reprogramming through the downstream signaling pathways. Protein kinases, such as AKT and c-MYC, are the integral components that facilitate the crosstalk bet…
Molecular Mechanisms of the Crosstalk Between Mitochondrial and NADPH Oxidase Derived Reactive Oxygen Species in White Blood Cells - Implications for…
2012
Confined crystallization of a HKUST-1 metal–organic framework within mesostructured silica with enhanced structural resistance towards water
2017
A HKUST-1 metal–organic framework was crystallized in the NH2-modified mesostructured silica FDU-12 in order to improve its structural stability upon water exposure. In-depth structural characterization studies of the designed composite confirmed successful formation of the MOF phase within the ordered spherical mesopores of the silica matrix. In spite of the confinement within the cavities, MOF exhibits full accessibility for the adsorbed gas molecules. In contrast to the bulk HKUST-1, which undergoes slow phase transition in a humid environment, the structural integrity of the HKUST-1 in the humid-protective matrix remains unchanged even after immersion and stirring in water at elevated t…
Photoplethysmograhic sensors, potential and limitations: Is it time for regulation? A comprehensive review
2023
Healthcare is expected to increasingly shift care out of inpatient settings thanks to wearable monitoring systems. Photoplethysmography (PPG) is an optical technique already integrated into wrist-worn commercial products which presents significant advantages in terms of cost and dimensions. PPG-based devices, despite their ability to detect multiple cardiovascular parameters, are affected by several influencing conditions that depend both on technological or environmental variables, and on intra- and inter-subject variability that influences the whole measurement chain and reliability, hindering an objective characterization of PPG devices. Plus, the lack of standardization for data collect…
Two-photon microscopy and neuroinflammation: Crosstalk between T cells and neurons
2014
Spectral imaging system for money counterfeit detection
2019
A prototype with three different wavelength lasers (448nm, 532nm and 659nm) for money counterfeit illumination, analyzation and detection using RGB crosstalk correction and comparing spectral image ration for different banknote elements will be presented.
Molecular Mechanisms of the Crosstalk Between Mitochondria and NADPH Oxidase Through Reactive Oxygen Species—Studies in White Blood Cells and in Anim…
2014
Aims: Oxidative stress is involved in the development of cardiovascular disease. There is a growing body of evidence for a crosstalk between different enzymatic sources of oxidative stress. With the present study, we sought to determine the underlying crosstalk mechanisms, the role of the mitochondrial permeability transition pore (mPTP), and its link to endothelial dysfunction. Results: NADPH oxidase (Nox) activation (oxidative burst and translocation of cytosolic Nox subunits) was observed in response to mitochondrial reactive oxygen species (mtROS) formation in human leukocytes. In vitro, mtROS-induced Nox activation was prevented by inhibitors of the mPTP, protein kinase C, tyrosine kin…