Search results for "STAGE"
showing 10 items of 1393 documents
Nonlinear EEG dynamics during sleep in depression and schizophrenia.
1994
The article deals with the question, whether nonlinear analysis of the sleep EEG may give clues to understanding of disturbed information processing in psychiatric diseases. We point out how the nonlinear approach to EEG dynamics is motivated and review recent investigations concerning nonlinear dynamical properties of physiological systems. We present calculations of the correlation dimension D2 and the principal Lyapunov-exponent lambda 1 for sleep EEG data from 9 depressive and 11 schizophrenic inpatients compared to healthy controls. Combining the findings for D2 and lambda 1 our results point to altered nonlinear brain dynamics mainly during slow wave sleep in depression and during REM…
Estimation of the dimensionality of sleep-EEG data in schizophrenics
1993
Deterministic chaos could be regarded as a healthy flexibility of the human brain necessary for correct neuronal operations. Several investigations have demonstrated that in healthy subjects the dimensionality of REM sleep is much higher than that of slow wave sleep (SWS). We investigated the sleep-EEG of schizophrenic patients with methods from nonlinear system theory in order to estimate the dynamic properties of CNS. We hypothesized that schizophrenics would reveal alterations of their dynamic EEG features indicating impaired information processing. In 11 schizophrenic patients, the EEG's dimensionality during sleep stages II and REM was reduced. We suggest that such lower dimensional ch…
An analysis of the brain's transfer properties in schizophrenia: Amplitude frequency characteristics and evoked potentials during sleep
1998
Background: Classical analysis of spontaneous sleep electroencephalogram (EEG) in schizophrenia commonly reveals alterations of sleep continuity, number of awakenings, slow-wave sleep (SWS), and REM sleep compared to healthy controls; however, conventional analysis cannot help understand dynamic differences of the sleep EEG during different sleep stages. Methods: We measured late components of auditory evoked potentials (AEPs) and visual evoked potentials (VEPs) during different sleep stages of 11 schizophrenic inpatients and in a sex- and age-matched control group from scalp positions FZ, CZ, and PZ. According to linear system theory, we then computed the amplitude-frequency characteristic…
Lungscape: Resected Non–Small-Cell Lung Cancer Outcome by Clinical and Pathological Parameters
2014
INTRODUCTION: The Lungscape project was designed to address the impact of clinical, pathological, and molecular characteristics on outcome in resected non-small- cell lung cancer (NSCLC).MATERIALS AND METHODS: A decentralized biobank with fully annotated tissue samples was established. Selection criteria for participating centers included sufficient number of cases, tissue microarray building capability, and documented ethical approval. Patient selection was based on availability of comprehensive clinical data, radical resection between 2003 and 2009 with adequate follow-up, and adequate quantity and quality of formalin-fixed tissue.RESULTS: Fifteen centers contributed 2449 cases. The 5-yea…
Multicentric evaluation of model for end-stage liver disease-based allocation and survival after liver transplantation in Germany - Limitations of th…
2010
Summary Since the introduction of model for end-stage liver disease (MELD) in 2006, post-orthotopic liver transplantation (OLT) survival in Germany has declined. The aim of this study was to evaluate risk factors and prognostic scores for outcome. All adult OLT recipients in seven German transplant centers after MELD implementation (December 2006–December 2007) were included. Recipient data were analyzed for their influence on 1-year outcome. A total of 462 patients (mean calculated MELD = 20.5, follow-up: 1 year) were transplanted for alcoholic cirrhosis (33.1%), hepatocellular carcinoma (26.6%), Hepatitis-C (17.1%), Hepatitis-B (9.5%), primary sclerosing cholangitis (5.6%) and late graft-…
Infrequent early recanalization of greater saphenous vein after endovenous laser treatment
2003
Abstract Objective The frequency of recanalization of the greater saphenous vein (GSV) after endovenous laser treatment (ELT) is unclear. This study was undertaken to establish the incidence of early recanalization after ELT and to study the histopathologic features of reperfused and excised GSV. Methods One hundred nine GSV in 85 consecutive patients with clinical stage C 2-6 E P,S A S,P,D P R disease were treated with ELT. Twelve months of follow-up with duplex scanning at regular intervals was possible in 104 treated veins (95.4%) in 82 patients (96.5%). Recanalized vessels were removed surgically and examined at histopathology. Results ELT-induced occlusion proved permanent at duplex sc…
Human Hepatocyte Transplantation in Patients with Hepatic Failure Awaiting a Graft
2012
<b><i>Background:</i></b> Hepatocyte transplantation (HT) has the potential to become a promising treatment to temporarily support liver function in patients with liver failure. <b><i>Methods:</i></b> Two patients, who had already received a liver transplant (LT) in the past, with an end-stage liver disease due to recurrent hepatitis C virus cirrhosis, suffering acute-on-chronic liver failure while on the waiting list for an LT, received HT as a bridge to whole-organ retransplantation. After HT and during intensive care unit admission, blood tests and ammonia levels were determined every 12 and 24 h, respectively, before and after each hepatoc…
Sarcopenia as prognostic factor for survival after orthotopic liver transplantation
2020
Background and aim Body composition has emerged as a prognostic factor for end-stage liver disease. We therefore investigated muscle mass, body fat and other clinical-pathological variables as predictors of posttransplant survival. Methods A total of 368 patients, who underwent orthotopic liver transplantation (OLT) at our institution, were assessed prior to OLT and followed for a median of 9.0 years (range 2.0-10.0 years) after OLT. Psoas, erector spinae and the combined paraspinal muscle area, as well as the corresponding indices normalized by body-height squared, were quantified by a lumbar (L3) cross-sectional computed tomography. In addition, absolute body fat and bone density were est…
Analysis of sleep EEG microstructure in subchronic paroxetine treatment of healthy subjects
1997
Paroxetine is a selective and potent serotonin reuptake inhibitor and its efficacy for the treatment of depression has been proven. Under acute and subchronical treatment regimens, disturbances of the regular sleep pattern are a reported side effect of the drug. The present study was therefore performed to investigate the impact of subchronic treatment with the selective serotonin reuptake inhibitor paroxetine on the microstructure of the sleep EEG. The study especially addressed the question of subchronic effects of paroxetine medication (30 mg/day) in eight healthy male volunteers in a double blind, placebo-controlled crossover design. Conventional sleep EEG parameters and a spectral powe…
Excitability and susceptibility of the brain's electrical activity during sleep: an analysis of late components of AEPs and VEPs.
1991
We investigated ten healthy male subjects and measured late components of AEPs and VEPs during sleep. According to Rechtschaffen and Kales (1968) we performed an off-line scoring procedure of sleep-EEG and averaged the AEPs and VEPs of five different periods, corresponding to sleep stages I, II, III, IV and REM. From the averaged evoked potentials we computed the amplitude-frequency-characteristic (AFC) of the brain (Basar, 1980) during different sleep stages. These AFCs characterize transfer properties of an oscillating system. A comparison of different AFCs has shown that the excitability of the brain depicts a clear alpha resonance during stage I, a pronounced delta resonance during stag…