Search results for "STAGE"
showing 10 items of 1393 documents
Could the Combined Administration of Bone Antiresorptive Drug, Taxanes, and Corticosteroids Worsen Medication Related Osteonecrosis of the Jaws in Ca…
2018
The study presents a report of 58 metastatic cancer patients who developed osteonecrosis of the jaws after being treated with zoledronic acid and taxanes, plus corticosteroids. A retrospective analysis of data registered in the archives of two Italian osteonecrosis of the jaws treatment centers, who are based at the University of Messina and at the University of Palermo, was performed in order to study, in these patients, demographic data and characteristics such as frequency of cancer location, lines of therapy, frequency of cancer drugs, presence/absence of oral trigger, number, location, and stage of jaw osteonecrosis. It was found that the majority of patients developed advanced stages …
L’auto-évaluation au service du développement professionnel des personnels de direction stagiaires
2022
Données socio-économiques, in : Dépistage et gestion du mésusage de substances psychoactives (SPA) susceptibles de générer des troubles du comporteme…
2013
National audience
Quand des médecins libéraux participent à une politique publique sans toujours s’y impliquer : les généralistes et le dépistage organisé des cancers
2015
National audience
Methyl-CpG-binding domain sequencing reveals a prognostic methylation signature in neuroblastoma
2016
Accurate assessment of neuroblastoma outcome prediction remains challenging. Therefore, this study aims at establishing novel prognostic tumor DNA methylation biomarkers. In total, 396 low- and high-risk primary tumors were analyzed, of which 87 were profiled using methyl-CpG-binding domain (MBD) sequencing for differential methylation analysis between prognostic patient groups. Subsequently, methylation-specific PCR (MSP) assays were developed for 78 top-ranking differentially methylated regions and tested on two independent cohorts of 132 and 177 samples, respectively. Further, a new statistical framework was used to identify a robust set of MSP assays of which the methylation score (i.e.…
Within-host evolution decreases virulence in an opportunistic bacterial pathogen
2015
Abstract Background Pathogens evolve in a close antagonistic relationship with their hosts. The conventional theory proposes that evolution of virulence is highly dependent on the efficiency of direct host-to-host transmission. Many opportunistic pathogens, however, are not strictly dependent on the hosts due to their ability to reproduce in the free-living environment. Therefore it is likely that conflicting selection pressures for growth and survival outside versus within the host, rather than transmission potential, shape the evolution of virulence in opportunists. We tested the role of within-host selection in evolution of virulence by letting a pathogen Serratia marcescens db11 sequent…
The development of interests and the supporting role of the parent at the early childhood education stage
2019
Currently, we live in instant culture reality depicting quick and immediate changes, in the era of continuous creation and manifestation of people succeeding in sport, music, dance or acting. An effective measure to ensure the child’s success in the future is an intensive satisfaction of his/her cognitive needs through the child’s participation in extra-curricular activities fulfilling his/her free time. On the educational market we are currently observing an intense increase in parents and children’s interest in additional, paid, classes enabling their comprehensive development. The aim of the presented article is an attempt to assess the phenomenon of 1–3-grades children’s participation i…
Role of protozooplankton in the diet of North Sea autumn spawning herring (Clupea harengus) larvae
2022
AbstractThe role of small prey (< 200 µm) in larval marine fish nutrition is largely understudied. Here, we explore the contribution of protozooplankton (PZP 20–200 µm) to larval fish diets, compared to metazoan microzooplankton (MZP 55–200 µm). More specifically, we tested whether the contribution of PZP increased during the low productivity season and decreased as larvae grow. We used North Sea autumn spawning herring (Clupea harengus) as a case study, as it is a key species with high commercial and ecological importance. In autumn and winter, the potential PZP and MZP prey was dominated by cells < 50 µm (mainly Gymnodiniales, Pronoctiluca pelagica,Tripos spp. and Strombidium spp.),…
Use of physicochemical processing in treating urban waste waters
1994
The principal objective of the present study was to compare two clearly defined purification processes in two stages: the periods 1985–1987 (conventional) and 1988–1990 (physico‐chemical). In general, the mean concentrations obtained were lower in the second period. A z‐test for comparing means was applied, but no significant correlation was observed (p ≤ 0.05). The mean concentrations obtained (with some exceptions) are lower in the second period. With the passing of time, the total volume of sewage flow has increased, and hence the load of contaminants has become diluted. The use of physico‐chemical treatment prior to biological processing may be the cause of the increase in cost.
Lifting the Vendace, Coregonus albula, on the Life Table : Survival, Growth and Reproduction in Different Life-Stages during Very High and Low Abunda…
2021
We analyzed the variability in vendace population parameters in the context of a life table. Parameters related to growth, fecundity and survival were estimated for post-recruitment (age > 1 growing season) life stages of Lake Southern Konnevesi vendace in both very high and low population abundance regimes. Pre-recruitment survival producing population stability was then determined. We found a very strong compensatory density dependence in growth, fecundity and survival: during low abundance, a lifetime reproductive output of a female was almost 20 times that of the abundant regime. To maintain the low abundance regime, pre-recruitment survival must counterbalance it by decreasing to a ver…