Search results for "STELLA"
showing 10 items of 1995 documents
Increased intrahepatic and circulating levels of endoglin, a TGF-β1 co-receptor, in patients with chronic hepatitis C virus infection: relationship t…
2006
Endoglin, a transforming growth factor (TGF)-beta1 co-receptor, has been associated with renal and cutaneous fibrosis, as overexpression of this protein has been observed in biopsies from patients with glomerulosclerosis and scleroderma, respectively. Our aim was to evaluate whether endoglin may be associated with hepatic fibrosis featuring chronic hepatitis C virus (HCV) infection. Fifty-two anti-HCV+ patients, five anti-HCV- patients and 27 healthy subjects were studied. Western blot and immunohistochemistry were used to quantify the expression levels of endoglin and TGF-beta1 in liver biopsy samples, and serum concentrations of endoglin and hyaluronic acid were determined by enzyme-linke…
Hepatitis C virus-specific T-cell-derived transforming growth factor beta is associated with slow hepatic fibrogenesis.
2011
Up to 4 million persons in the USA have chronic hepatitis C (CHC) (1). Despite a decline in overall HCV infections, the number of patients with end stage liver disease due to CHC will increase for the next 2 decades (2). Even with highly effective novel therapies, currently 30–50% of infected individuals fail treatment (3). Therefore, a better understanding of mechanisms involved in CHC-related liver disease progression could permit more efficient therapies. Adaptive effector T cells (frequently assessed by measuring production of prototypic T helper 1 cytokine IFNγ) play an important role in control of HCV infection during the acute phase (4). In CHC, effector HCV-specific T cell immune re…
PTCH-1 and MDM2 expression in ameloblastoma from a West African sub-population: implication for chemotherapeutics
2015
INTRODUCTION: ameloblastoma is a slow growing, painless odontogenic swelling which can attain sizes that result in severe deformities of the craniofacial complex. It is the most commonly encountered odontogenic tumor in Nigeria. Surgical intervention is currently the method of treatment; however identification of altered molecular pathways may inform chemotherapeutic potential. The Protein Patched homolog 1 (PTCH-1) is overexpressed in ameloblastoma. Also, mutation in the MDM2 gene can reduce the tumor suppressor function of p53 and promote ameloblastoma growth. No study however has characterized the molecular profile of African cases of ameloblastoma with a view to developing chemotherapeu…
Hepatogenic differentiation of human mesenchymal stem cells from adipose tissue in comparison with bone marrow mesenchymal stem cells
2006
AIM: To investigate and compare the hepatogenic transdifferentiation of adipose tissue-derived stem cells (ADSC) and bone marrow-derived mesenchymal stem cells (BMSC) in vitro. Transdifferentiation of BMSC into hepatic cells in vivo has been described. Adipose tissue represents an accessible source of ADSC, with similar characteristics to BMSC. METHODS: BMSCs were obtained from patients undergoing total hip arthroplasty and ADSC from human adipose tissue obtained from lipectomy. Cells were grown in medium containing 15% human serum. Cultures were serum deprived for 2 d before cultivating under similar pro-hepatogenic conditions to those of liver development using a 2-step protocol with sequ…
Conectores y secuencias didácticas en primer ciclo de educación primaria
2017
El punto de partida con el que iniciamos este artículo relaciona la enseñanza de elementos gramaticales, como los conectores, con la producción textual de escolares de segundo curso de Educación Primaria. En la investigación, que se lleva a cabo en aula, se elige como dispositivo una secuencia didáctica inspirada en el modelo de la escuela de Ginebra. La mediación elegida demuestra que resulta posible y eficaz introducir estos saberes gramaticales desde el inicio de la escolarización y que estos elementos ayudan, junto con el resto de la intervención, a mejorar los textos de los niños. Para ello aportamos el análisis de la producción inicial y final de un alumno y los resultados obtenidos d…
Cronica del muy esclarecido Principe y Rey don Alonso el onzeno deste nombre, de los Reyes que reynaron en Castilla, y en Leon, padre que fue del Rey…
1595
Escut reial en la port. - Errors tipogr. en la fol. - Capll. orn.
NMR and homology modeling studies of copper(II)-halocyanin from Natronobacterium pharaonis bacteria
2004
Abstract Halocyanin from the haloalkaliphilic archaean Natronobacterium pharaonis is a peripheral membrane type 1 blue copper protein with a single polypeptide chain of 163 amino acid residues. Halocyanin participates as putative electron carrier protein associated to an electron acceptor role for a terminal oxidase and has the lowest redox potential value reported to date for a BCP. NMR studies and homology modeling calculations were performed to evaluate the electronic properties of Cu(II)-halocyanin from Natronobacterium pharaonis . The copper coordination site properties of Cu(II)-halocyanin are discussed. The 1 H NMR spectra, isotropic chemical shifts and relaxation times for halocyani…
Optical and ultraviolet pulsed emission from an accreting millisecond pulsar
2021
Ambrosino, F., et al.
Neutrino pair annihilation near accreting, stellar-mass black holes
2006
We investigate the energy-momentum deposition due to neutrino-antineutrino annihilation in the vicinity of axisymmetric, accreting black holes (BHs) by numerically ray-tracing neutrino trajectories in a Kerr space-time. Hyperaccreting stellar-mass BHs are widely considered as energy sources that can drive ultrarelativistic outflows with the potential to produce gamma-ray bursts. In contrast to earlier works, we provide an extensive and detailed parameter study of the influence of general relativistic (GR) effects and of different neutrinosphere geometries. These include idealized thin disks, tori, and spheres, or are constructed as non-selfgravitating equilibrium matter distributions for va…
Mass Accretion Processes in Young Stellar Objects: Role of Intense Flaring Activity
2014
According to the magnetospheric accretion scenario, young low-mass stars are surrounded by circumstellar disks which they interact with through accretion of mass. The accretion builds up the star to its final mass and is also believed to power the mass outflows, which may in turn have a significant role in removing the excess angular momentum from the star-disk system. Although the process of mass accretion is a critical aspect of star formation, some of its mechanisms are still to be fully understood. On the other hand, strong flaring activity is a common feature of young stellar objects (YSOs). In the Sun, such events give rise to perturbations of the interplanetary medium. Similar but mo…