Search results for "STELLA"

showing 10 items of 1995 documents

Evaluation of the cytotoxic effects of MEIC chemicals 31-50 on primary culture of rat hepatocytes and hepatic and non-hepatic cell lines

1997

The cytotoxicities of 20 chemicals (numbers 31–50) from the Multicenter Evaluation of In Vitro Cytotoxicity (MEIC) programme were assessed with a primary culture of rat hepatocytes and with two hepatic cell lines (Hep G2 and FaO) and one non-hepatic cell line (3T3). The cytotoxicities of the chemicals were evaluated by using the MTT test after the cells had been exposed to the chemicals for 24 hours. For a better evaluation of results, dose–response curves were mathematically linearised and cytotoxicity was expressed as IC50 values and IC10 values (the concentration causing 50% and 10% loss of cell viability, respectively). We found that all the compounds showed similar acute basal cytotox…

General MedicinePharmacologyBiologyToxicologyGeneral Biochemistry Genetics and Molecular BiologyIn vitroHep G2Medical Laboratory Technologymedicine.anatomical_structureCell cultureHepatocyteImmunologyToxicityHepatic stellate cellmedicineCytotoxic T cellCytotoxicity
researchProduct

Main Sequence Stars with Asymmetric Dark Matter

2012

We study the effects of feebly or non-annihilating weakly interacting Dark Matter (DM) particles on stars that live in DM environments denser than that of our Sun. We find that the energy transport mechanism induced by DM particles can produce unusual conditions in the core of Main Sequence stars, with effects which can potentially be used to probe DM properties. We find that solar mass stars placed in DM densities of rhochi>= e2 GeV/cm3 are sensitive to Spin-Dependent scattering cross-section sigmsd >= e-37 cm2 and a DM particle mass as low as mchi=5 GeV, accessing a parameter range weakly constrained by current direct detection experiments.

General Physicsastro-ph.SRPhysics MultidisciplinaryDark matterFOS: Physical sciencesGeneral Physics and AstronomyAstrophysics01 natural sciencesHigh Energy Physics - Phenomenology (hep-ph)0103 physical sciences010303 astronomy & astrophysicsLight dark matterSolar and Stellar Astrophysics (astro-ph.SR)PhysicsSolar massRange (particle radiation)Science & Technology02 Physical Sciences010308 nuclear & particles physicsPhysicsHot dark matter1ST STARShep-phHigh Energy Physics - PhenomenologyStarsAstrophysics - Solar and Stellar AstrophysicsSTELLAR EVOLUTION13. Climate actionPhysical SciencesMixed dark matterAstrophysics::Earth and Planetary AstrophysicsMain sequencePhysical Review Letters
researchProduct

"Table 26" of "Multiplicity dependence of K*(892)$^{0}$ and $\phi$(1020) production in pp collisions at $\sqrt{s}$ = 13 TeV"

2020

$\phi$ transverse momentum spectrum - V0M multiplicity class VIII

General Relativity and Quantum Cosmology13000.0YieldsAstrophysics::High Energy Astrophysical PhenomenaProton-Proton CollisionsPhysics::Space PhysicsAstrophysics::Solar and Stellar AstrophysicsNuclear ExperimentSIGPhiResonanceP P --> Phi+XV0M Multiplicity
researchProduct

"Table 36" of "Multiplicity dependence of K*(892)$^{0}$ and $\phi$(1020) production in pp collisions at $\sqrt{s}$ = 13 TeV"

2020

$\phi$ transverse momentum spectrum ratio to INEL>0 - V0M multiplicity class VIII

General Relativity and Quantum Cosmology13000.0YieldsProton-Proton CollisionsAstrophysics::Solar and Stellar AstrophysicsSIGPhiResonanceP P --> Phi+XV0M Multiplicity
researchProduct

"Table 7" of "Multiplicity dependence of K*(892)$^{0}$ and $\phi$(1020) production in pp collisions at $\sqrt{s}$ = 13 TeV"

2020

K$^{*0}$ transverse momentum spectrum - V0M multiplicity class VIII, average of particle and antiparticle

General Relativity and Quantum CosmologyPhysics::General PhysicsP P --> Kstar+XKstar13000.0YieldsProton-Proton CollisionsAstrophysics::Solar and Stellar AstrophysicsSIGResonanceV0M Multiplicity
researchProduct

Causes of the genetic architecture of south-west European high mountain disjuncts

2008

Background: Postglacial climatic warming in south-western Europe and the retreat of cold-adapted species into higher elevations, starting in the Sierra Nevada and proceeding northwards to the Pyrenees and Alps, should have resulted in a pattern of ‘successive vicariance’. Alternatively, long-distance dispersal might explain the extant distribution pattern of mountain species in this region. Aims: Here, we report an investigation of two alpine plants, Saxifraga oppositifolia and S. stellaris, which co-occur in the Sierra Nevada, the Pyrenees, and the south-western Alps/Massif Central. Our aim was to distinguish between (successive) vicariance and long-distance dispersal as alternative explan…

Genetic diversitygeography.geographical_feature_categoryEcologybiologyEcologyPlant ScienceSaxifraga stellarisMassifbiology.organism_classificationSaxifraga oppositifoliaGenetic architectureHigh mountainGeographyVicarianceBiological dispersalEcology Evolution Behavior and SystematicsPlant Ecology & Diversity
researchProduct

TGF-beta1 in liver fibrosis: an inducible transgenic mouse model to study liver fibrogenesis.

1999

Transforming growth factor-beta1 (TGF-beta1) is a powerful stimulus for collagen formation in vitro. To determine the in vivo effects of TGF-beta1 on liver fibrogenesis, we generated transgenic mice overexpressing a fusion gene [C-reactive protein (CRP)/TGF-beta1] consisting of the cDNA coding for an activated form of TGF-beta1 under the control of the regulatory elements of the inducible human CRP gene promoter. Two transgenic lines were generated with liver-specific overexpression of mature TGF-beta1. After induction of the acute phase response (15 h) with lipopolysaccharide (100 microgram ip), plasma TGF-beta1 levels reached600 ng/ml in transgenic animals, which is100 times above normal …

Genetically modified mouseLipopolysaccharidesmedicine.medical_specialtyTranscription GeneticPhysiologyTransgeneRecombinant Fusion ProteinsMice TransgenicBiologyRegulatory Sequences Nucleic AcidLiver Cirrhosis ExperimentalMiceDownregulation and upregulationFibrosisIn vivoTransforming Growth Factor betaPhysiology (medical)Internal medicinemedicineAnimalsHumansRNA MessengerPromoter Regions GeneticRegulation of gene expressionHepatologyGastroenterologymedicine.diseaseMolecular biologyImmunohistochemistryEndocrinologymedicine.anatomical_structureC-Reactive ProteinGene Expression RegulationLiverHepatocyteHepatic stellate cellCollagenProcollagen
researchProduct

Spontaneous hepatic fibrosis in transgenic mice overexpressing PDGF-A.

2008

Platelet derived growth factor (PDGF) plays a central role in repair mechanisms after acute and chronic tissue damage. To further evaluate the role of PDGF-A in liver fibrogenesis in vivo, we generated transgenic mice with hepatocyte-specific overexpression of PDGF-A using the CRP-gene promoter. Transgenic but not wildtype mice showed expression of PDGF-A mRNA in the liver. Hepatic PDGF-A overexpression was accompanied by a significant increase in hepatic procollagen III mRNA expression as well as TGF-beta1 expression. Liver histology showed increased deposition of extracellular matrix in transgenic but not in wildtype mice. PDGF-A-transgenic mice showed positive sinusoidal staining for alp…

Genetically modified mouseLiver CirrhosisPlatelet-derived growth factorTransgeneGene ExpressionMice TransgenicTransforming Growth Factor beta1chemistry.chemical_compoundMiceFibrosisGeneticsmedicineAnimalsHumansRNA MessengerPlatelet-Derived Growth FactorbiologyGeneral Medicinemedicine.diseaseMolecular biologyRecombinant ProteinsC-Reactive ProteinCollagen Type IIIchemistryLiverHepatic stellate cellbiology.proteinHepatic fibrosisTyrosine kinasePlatelet-derived growth factor receptorSignal TransductionGene
researchProduct

Plano de rodales del monte La Garganta de los propios del Espinar

1863

Llegenda amb "apeo de rodales". - Taules amb dades del "pino silvestre". - Llegenda amb gradació de tono senyalant l'edat del pi roig

Geologia Castella i Lleó Àvila (Província) MapesArboricultura Castella i Lleó Àvila (Província) Mapes
researchProduct

Solar and interplanetary triggers of the largest Dst variations of the solar cycle 23

2012

Abstract We present the results of an investigation from the Sun to the Earth of the sequence of events that caused major Dst decreases (Δ Dst ≤ – 100 nT during 1 h) that occurred during 1996–2005. These events are expected to be better related to geomagnetic induced current (GIC) events than those events where any geomagnetic index is far from its quiet time value. At least one full halo CME with a speed on the plane of sky above 900 km/s participates in every studied event. The seven events were triggered by interplanetary signatures, which arise as a consequence of interaction among different solar ejections. The interaction arises at different stages from the solar surface, between segm…

Geomagnetic stormPhysicsAtmospheric ScienceIonospheric dynamo regionInterplanetary mediumAstronomySolar physicsSolar windGeophysicsEarth's magnetic fieldSpace and Planetary SciencePhysics::Space PhysicsCoronal mass ejectionAstrophysics::Solar and Stellar AstrophysicsInterplanetary spaceflightJournal of Atmospheric and Solar-Terrestrial Physics
researchProduct