Search results for "STICS"

Systematic Study of a Library of PDMAEMA-Based, Superparamagnetic Nano-Stars for the Transfection of CHO-K1 Cells.

2017

The introduction of the DNA into mammalian cells remains a challenge in gene delivery, particularly in vivo. Viral vectors are unmatched in their efficiency for gene delivery, but may trigger immune responses and cause severe side-reactions. Non-viral vectors are much less efficient. Recently, our group has suggested that a star-shaped structure improves and even transforms the gene delivery capability of synthetic polycations. In this contribution, this effect was systematically studied using a library of highly homogeneous, paramagnetic nano-star polycations with varied arm lengths and grafting densities. Gene delivery was conducted in CHO-K1 cells, using a plasmid encoding a green fluore…

Spoken-Word Segmentation and Dyslexia

2002

We used magnetoencephalography to elucidate the cortical activation associated with the segmentation of spoken words in nonreading-impaired and dyslexic adults. The subjects listened to binaurally presented sentences where the sentence-ending words were either semantically appropriate or inappropriate to the preceding sentence context. Half of the inappropriate final words shared two or three initial phonemes with the highly expected semantically appropriate words. Two temporally and functionally distinct response patterns were detected in the superior temporal lobe. The first response peaked at approximately 100 msec in the supratemporal plane and showed no sensitivity to the semantic appr…

Attention directed to proprioceptive stimulation alters its cortical processing in the primary sensorimotor cortex.

2021

Funding Information: This study has been supported by the Academy of Finland ”Brain changes across the life‐span” profiling funding to University of Jyväskylä (grant #311877). HP was supported by Academy of Finland (grants #296240, #326988, #307250 and #327288) to HP and Jane and Aatos Erkko Foundation (grant #602.274). Publisher Copyright: © 2021 The Authors. European Journal of Neuroscience published by Federation of European Neuroscience Societies and John Wiley & Sons Ltd. Copyright: Copyright 2021 Elsevier B.V., All rights reserved. Movement-evoked fields to passive movements and corticokinematic coherence between limb kinematics and magnetoencephalographic signals can both be used to …

Adding ‘Sense’ to Conceptual Modeling : An Interdisciplinary Approach

2019

In this paper, our aim is to widen the prevailing foundations of conceptual modeling theories and practices, particularly in the context of information systems development. The approach shifts the focus from the link between a model and the modelled reality to the link between human cognition and the model. Our approach combines theoretical issues of different disciplines relevant to conceptual modeling. We shall make an explicit distinction between individual conceptions and interpersonal concepts and show how this distinction could be utilized to have conceptual models of a better consistency. We wish that this article could also serve as a starting point for a profound scientific discuss…

Osnovnye napravleniâ teolingvističeskih issledovanij v polʹskom i russkom âzykoznanii

2016

The links between the Polish and Russian linguistics are not only history but also a present fact. Theolinguistics’ development and research in the field of modern comparative linguistics led to the fact tliat at the turn of 20th -21th centuries, scientists bcgan to pay attention to the emerging problems of comparative Polish and Russian theolinguistics. A valuable contribution to the flourishing of Slavonic theolinguistics was made by the Polish researchers, who got not only accepted by the western researchers of English Theolinguistics, but also enriched it with new content, thereby giving a new start to the development of Slavonic theolinguistics. To date, the Polish and Russian theoling…

Retour sur la crise de l’euro (2008-2018) : 10 ans après, le malade est-il guéri ? L’image du corps et de la maladie dans le discours économique de m…

2021

Bayesian semiparametric long memory models for discretized event data

2020

We introduce a new class of semiparametric latent variable models for long memory discretized event data. The proposed methodology is motivated by a study of bird vocalizations in the Amazon rain forest; the timings of vocalizations exhibit self-similarity and long range dependence. This rules out Poisson process based models where the rate function itself is not long range dependent. The proposed class of FRActional Probit (FRAP) models is based on thresholding, a latent process. This latent process is modeled by a smooth Gaussian process and a fractional Brownian motion by assuming an additive structure. We develop a Bayesian approach to inference using Markov chain Monte Carlo and show g…

Numerical methods for acoustics and noise control

2010

Artikkeliväitöskirja. Sisältää yhteenveto-osan ja viisi artikkelia. Article dissertation. Contains an introduction part and five articles. This dissertation considers numerical methods for wave propagation modelling and noise control. The first part of the dissertation discusses an efficient method for solving time-harmonic wave equations in acoustic (the Helmholtz equation) and elastic domains (the Navier equation). The solver is based on preconditioning a Krylov subspace method, such as GMRES, with approximations of damped variants of the corresponding wave equations. An algebraic multigrid method is used in approximating the inverse of damped operators. The method can be used in complex …

Multi-objective actuator placement optimization for local sound control evaluated in a stochastic domain

2011

A method to find optimal locations and properties of anti-noise actuators in local noise control system is considered. The local noise control performance is approximated by a finite element method based approach, that attempts to estimate the average performance of optimal active noise control (ANC) system. The local noise control uses a fixed number of circular actuators that are located on the boundary of a three-dimensional enclosed acoustic space. Actuator signals are used to minimize the known harmonic noise at specified locations. The average noise reduction is maximized at two frequency ranges by adjusting the anti-noise actuator configuration, which is a non-linear multi-objective …

Multi-objective actuator placement optimization for local sound control evaluated in a stochastic domain

2013

A method to find optimal locations and properties of anti-noise actuators in a local noise control system is considered. The local noise control performance is approximated by an approach based on a finite element method, attempting to estimate the average performance of an optimal active noise control (ANC) system. Local noise control uses a fixed number of circular actuators that are located on the boundary of a three-dimensional enclosed acoustic space. Actuator signals are used to minimize the known harmonic noise at specified locations. The average noise reduction is maximized at two frequency ranges by adjusting the anti-noise actuator configuration, which is a non-linear multi-object…