Search results for "STICS"
showing 10 items of 21128 documents
The Scope of Application of Macrocyclic Polyamines Beyond Metal Chelation
2019
International audience; Recent advances in the use of radiometals for both imaging and therapy has spurred on the development of an original chemistry that endows radionuclide-chelating molecular cages with ever sharper physicochemical properties. Macrocyclic polyamines (MPAs) such as cyclen and DOTA are among the most frequently encountered cages for the design of new radiotracers, owing to their versatile chemistry that makes them customizable molecular tools. The idea of using MPAs for alternative purposes has recently emerged, with an eye towards benefiting from their unique topology, versatility, symmetry and water-solubility. This review summarizes strategies that have been recently i…
Recombinant nanocapsid for targeted theranostic delivery
2017
Developments in diagnostic and therapeutic delivery are trending towards molecular level targeting with nano-platforms. Targeted delivery reduces generalized distribution by localizing diagnostic and/or therapeutic (theranostic) molecules to an intended target site. The first section of this thesis proposes Hepatitis E Virus (HEV) nanocapsids as a vector to stabilize and target theranostic delivery. Derived from the capsid protein of HEV, a feco-orally transmitted virus, HEV-like particles self-assemble in to non-infectious, nanocapsids that can withstand harsh protease and pH conditions in the mucosal system. The flexible nanocapsid surface protrusion domain is amenable to substantial modi…
The Beginning and Development of the Theranostic Approach in Nuclear Medicine, as Exemplified by the Radionuclide Pair
2017
In the context of radiopharmacy and molecular imaging, the concept of theranostics entails a therapy-accompanying diagnosis with the aim of a patient-specific treatment. Using the adequate diagnostic radiopharmaceutical, the disease and the state of the disease are verified for an individual patient. The other way around, it verifies that the radiopharmaceutical in hand represents a target-specific and selective molecule: the “best one” for that individual patient. Transforming diagnostic imaging into quantitative dosimetric information, the optimum radioactivity (expressed in maximum radiation dose to the target tissue and tolerable dose to healthy organs) of the adequate radiotherapeutica…
On the Choice of the Extracellular Vesicles for Therapeutic Purposes
2019
Extracellular vesicles (EVs) are lipid membrane vesicles released by all human cells and are widely recognized to be involved in many cellular processes, both in physiological and pathological conditions. They are mediators of cell-cell communication, at both paracrine and systemic levels, and therefore they are active players in cell differentiation, tissue homeostasis, and organ remodeling. Due to their ability to serve as a cargo for proteins, lipids, and nucleic acids, which often reflects the cellular source, they should be considered the future of the natural nanodelivery of bio-compounds. To date, natural nanovesicles, such as exosomes, have been shown to represent a source of diseas…
Self-reported reflective functioning mediates the association between attachment insecurity and well-being among psychotherapists.
2020
Objective: Subjective well-being is a crucial variable for mental health practitioners. This study examines the influence of therapists’ attachment dimensions and self-reported reflective functioning on their perceived well-being. Further, it examines if reflective functioning mediates the association between attachment insecurity and well-being. Method: A total of 416 experienced psychotherapists were enrolled in this cross-sectional study, and completed self-report measures of attachment insecurity, reflective functioning, and well-being. We tested the hypothesized mediation model with path analysis that examined indirect effects. Results: Both attachment anxiety and avoidance dimensions …
Wytyczne PTL/KLRWP/PTK/PTDL/PTD/PTNT diagnostyki i leczenia zaburzeń lipidowych w Polsce 2021
2021
Thermal and thermo-oxidative stability and kinetics of decomposition of PHBV/sisal composites
2017
The decomposition behaviours of composites made of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) and sisal were assessed in terms of thermal stability and decomposition kinetics, under inert and oxidative conditions, by means of multi-rate linear non-isothermal thermogravimetric experiments. A statistical design of experiments was applied to study the influence of the addition of sisal (0-10-20-30%wt), the presence coupling agent (Yes/No) and the applied conditions of work (inert or oxidative). An improvement of the thermal and thermo-oxidative stability of PHBV with the addition of sisal was observed for all cases. An accurate methodology based on iso-conversional methods was applied…
A Quantitative Analysis of the Thermoelastic Effect in CFRP Composite Materials
2010
In this study the thermoelastic signal from carbon fibre-reinforced plastic (CFRP) laminates is investigated. A comparison between the theoretical and experimental values of the thermoelastic signal is reported, with the theoretical predictions obtained from two different quantitative models. These models are based on the classic thermoelastic effect law extended to the case of orthotropic materials (by using the mesomechanical or bulk approach), and the modified law assuming that the surface resin-rich layer behaves as a strain witness of the laminate. It is found that the theoretical predictions of the two models can be strongly and differently influenced by the intrinsic orthotropy of ca…
Cyber Threat Analysis in Smart Terminal Systems
2023
Cyber threats create significant factors that challenge traditional threat prevention mechanisms in harbor areas and port terminals. It has been recognized that understanding security functionalities in the harbor area is based on a more traditional experience of what it requires. It is not enough that the maritime and harbor ecosystem repeats only physical security service routines regarding random checks of passengers and vehicles and customs functions on cargo and passenger transportation. Smart environments and infrastructures are widely expanded in urban areas and create more challenges if old practices are combined with new technologies and functionalities. Traditional threats have ch…
Les noms prédicatifs sont-ils solubles dans la théorie de Jean-Marie Zemb ?
2011
Manuscrit de 13 pages; Les analyses de la phrase sous la forme de structures prédicat-argument(s) semblent, ces derniers temps, connaître un regain d'intérêt non seulement dans les grammaires descriptives et explicatives mais aussi dans la recherche théorique où elles ont donné lieu à de vifs débats autour de la notion même de prédication et du rapport entre cette dernière et certaines classes de mots, en premier lieu le verbe et le nom. Dans le sillage de ce débat, il peut paraître opportun de revenir sur la place qu'occupe cette notion de prédication dans l'édifice conceptuel construit par Jean-Marie Zemb en s'interrogeant tout spécialement sur les liens potentiels pouvant exister entre d…