Search results for "STRESS"

Monitoring the chemical changes in Pd induced by hydrogen absorption using microcantilevers.

2003

Abstract The reactivity of the palladium shaped as a microcantilever is investigated as a function of the hydrogen stoichiometry. A small cell holding the microcantilever is designed to monitor the deflection and the flexural resonance response from high vacuum to a hydrogen gas pressure of several bars. The measurements show that the Young's modulus is accurate if the cantilever is thick enough to be described by a continuum mechanics approach. The orientation distribution function of the palladium grains determined by X-ray diffraction enables to correlate Young's modulus measured using microcantilevers with the elastic constant tensor issued from the literature. The surface stress induce…

Measurement of Mechanical Properties of Cantilever Shaped Materials

2008

Microcantilevers were first introduced as imaging probes in Atomic Force Microscopy (AFM) due to their extremely high sensitivity in measuring surface forces. The versatility of these probes, however, allows the sensing and measurement of a host of mechanical properties of various materials. Sensor parameters such as resonance frequency, quality factor, amplitude of vibration and bending due to a differential stress can all be simultaneously determined for a cantilever. When measuring the mechanical properties of materials, identifying and discerning the most influential parameters responsible for the observed changes in the cantilever response are important. We will, therefore, discuss the…

Effects of Foliar Application of Gibberellic Acid on the Salt Tolerance of Tomato and Sweet Pepper Transplants

2020

Seed germination and early seedling growth are the plant growth stages most sensitive to salt stress. Thus, the availability of poor-quality brackish water can be a big limiting factor for the nursery vegetable industry. The exogenous supplementation of gibberellic acid (GA3) may promote growth and vigor and counterbalance salt stress in mature plants. This study aimed to test exogenous supplementation through foliar spray of 10&minus

ANALISI E SVILUPPO DI UN SETUP SPERIMENTALE PER LA DETERMINAZIONE DELLA TENACITÀ A FRATTURA A MODO II NEI MATERIALI COMPOSITI E IBRIDI

Il presente lavoro di Tesi si propone a compimento del percorso previsto dal Ciclo XXVI del corso di Dottorato di Ricerca in Ingegneria Civile e Ambientale – Indirizzo Materiali – seguito durante il triennio Gennaio 2013- Dicembre 2015 presso l’Università degli Studi di Palermo. L’elaborato si sviluppa in due principali sezioni. Dopo un’introduzione all’argomento affrontato, nella prima parte del lavoro, viene analizzato, sia sperimentalmente che numericamente, un setup tipicamente utilizzato nell’industria aeronautica per la caratterizzazione delle delaminazione a MODO II nei materiali compositi (Transverse Crack Tensile test – TCT-test). A partire dai risultati ottenuti dalle analisi prel…

Exposure to moderate concentrations of tropospheric ozone impairs tree stomatal response to carbon dioxide.

2011

With rising concentrations of both atmospheric carbon dioxide (CO(2)) and tropospheric ozone (O(3)), it is important to better understand the interacting effects of these two trace gases on plant physiology affecting land-atmosphere gas exchange. We investigated the effect of growth under elevated CO(2) and O(3), singly and in combination, on the primary short-term stomatal response to CO(2) concentration in paper birch at the Aspen FACE experiment. Leaves from trees grown in elevated CO(2) and/or O(3) exhibited weaker short-term responses of stomatal conductance to both an increase and a decrease in CO(2) concentration from current ambient level. The impairement of the stomatal CO(2) respo…

Carbon monoxide: mechanisms of action and potential clinical implications.

2013

International audience; Small amounts of carbon monoxide (CO) are continuously produced in mammals. The intracellular levels of CO can increase under stressful conditions following the induction of HO-1 (heme oxygnase-1), a ubiquitous enzyme responsible for the catabolism of heme. Unlike nitric oxide, which is a free radical, CO does not contain free electrons but may be involved in oxidative stress. The carbonate radical has been proposed to be a key mediator of oxidative damage resulting from peroxynitrite production, likewise, the precursor of the carbonate radical anion being bicarbonate and carbon dioxide. We report herein some of the transcription factors and protein kinases involved …

Improving the preclinical models for the study of chemotherapy-induced cardiotoxicity: a Position Paper of the Italian Working Group on Drug Cardioto…

2015

Although treatment for heart failure induced by cancer therapy has improved in recent years, the prevalence of cardiomyopathy due to antineoplastic therapy remains significant worldwide. In addition to traditional mediators of myocardial damage, such as reactive oxygen species, new pathways and target cells should be considered responsible for the impairment of cardiac function during anticancer treatment. Accordingly, there is a need to develop novel therapeutic strategies to protect the heart from pharmacologic injury, and improve clinical outcomes in cancer patients. The development of novel protective therapies requires testing putative therapeutic strategies in appropriate animal model…

Impact of high-fat diet on antioxidant status, vascular wall thickening and cardiac function in adult female LDLR<sup>–/–</sup> mice

2012

International audience; Background: Western diet, rich in saturated fatty acids and cholesterol, is associated with increased cardiovascular risk. We thus investigated in female mice the influence of this diet on plasma antioxidant status, vascular wall thickening and cardiac function. Methods and Results: Adult female C57BL/6J wild type (WT) and LDLR–/– mice were fed a normal diet (ND) or a high-fat diet (HFD) for 17 weeks. HFD induced an increase in plasma lipids and vitamin C (Vit C) levels in both groups but at a much higher level in LDLR–/– and a decrease in plasma ascorbyl free radical levels to Vit C ratio (an endogenous oxidative stress index) in LDLR–/–. We only found a slight decr…

Ischemic stroke increases heart vulnerability to ischemia-reperfusion and alters myocardial cardioprotective pathways

2018

Background and Purpose— For years, the relationship between cardiac and neurological ischemic events has been limited to overlapping pathophysiological mechanisms and common risk factors. However, acute stroke may induce dramatic changes in cardiovascular function. The aim of this study was to evaluate how prior cerebrovascular lesions affect myocardial function and signaling in vivo and ex vivo and how they influence cardiac vulnerability to ischemia-reperfusion injury. Methods— Cerebral embolization was performed in adult Wistar male rats through the injection of microspheres into the left or right internal carotid artery. Stroke lesions were evaluated by microsphere counting, tissue sta…

miR-133a Enhances the Protective Capacity of Cardiac Progenitors Cells after Myocardial Infarction

2014

Summary miR-133a and miR-1 are known as muscle-specific microRNAs that are involved in cardiac development and pathophysiology. We have shown that both miR-1 and miR-133a are early and progressively upregulated during in vitro cardiac differentiation of adult cardiac progenitor cells (CPCs), but only miR-133a expression was enhanced under in vitro oxidative stress. miR-1 was demonstrated to favor differentiation of CPCs, whereas miR-133a overexpression protected CPCs against cell death, targeting, among others, the proapoptotic genes Bim and Bmf. miR-133a-CPCs clearly improved cardiac function in a rat myocardial infarction model by reducing fibrosis and hypertrophy and increasing vasculari…