Search results for "STRESS"

Metal ions modify DNA-protecting and mutagen-scavenging capacities of the AV-153 1,4-dihydropyridine.

2019

Abstract 1,4-Dihydropyridines (1,4-DHP) possess important biochemical and pharmacological properties, including antioxidant and antimutagenic activities. AV-153-Na, an antimutagenic and DNA-repair enhancing compound was shown to interact with DNA by intercalation. Here we studied DNA binding of several AV-153 salts to evaluate the impact of AV-153 modifications on its DNA binding capacity, the ability to scavenge the peroxynitrite, to protect HeLa and B-cells cells against DNA damage. Affinity of the AV-153 salts to DNA measured by a fluorescence assay was dependent on the metal ion forming a salt in position 4 of the 1,4-DHP, and it decreased as follows: Mg > Na > Ca > Li > Rb > K. AV-153-…

The Line Element-less Method Analysis of orthotropic beam for the De Saint Venant torsion problem

2010

Abstract This paper deals with the extension of a novel numerical technique, labelled line element-less method (LEM), in order to provide approximate solutions of the De Saint Venant torsion problem for orthotropic beams having simply and multiply connected cross-section. A suitable transformation of coordinates allows to take full advantage of the theory of analytic complex functions as in the isotropic case. A complex potential function analytic in all the transformed domain whose real and imaginary parts are related to the shear stress components and to the orthotropic ratio is introduced and expanded in the double-ended Laurent series involving harmonic polynomials. An element-free weak…

Line element-less method (LEM) for beam torsion solution (truly no-mesh method)

2008

In this paper a new numerical method for finding approximate solutions of the torsion problem is proposed. The method takes full advantage of the theory of analytic complex function. A new potential function directly in terms of shear stresses is proposed and expanded in the double-ended Laurent series involving harmonic polynomials. A novel element-free weak form procedure, labelled Line Element-Less Method (LEM), has been developed imposing that the square of the net flux across the border is minimum with respect to coefficients expansion. Numerical implementation of the LEM results in systems of linear algebraic equations involving symmetric and positive-definite matrices without resorti…

Guaranteed and computable error bounds for approximations constructed by an iterative decoupling of the Biot problem

2021

The paper is concerned with guaranteed a posteriori error estimates for a class of evolutionary problems related to poroelastic media governed by the quasi-static linear Biot equations. The system is decoupled by employing the fixed-stress split scheme, which leads to an iteratively solved semi-discrete system. The error bounds are derived by combining a posteriori estimates for contractive mappings with functional type error control for elliptic partial differential equations. The estimates are applicable to any approximation in the admissible functional space and are independent of the discretization method. They are fully computable, do not contain mesh-dependent constants, and provide r…

Endotelin-1 and 8-isoprostanes Predict Estimated Glomerular Filtration Rate in Arterial Hypertension

2008

Endotelina-1 e 8-isoprostano predicono il GFR stimato nell’ipertensione arteriosa

2008

Plasma endothelin-1 and 8-Iso-ProstaglandinF2alpha levels are related to renal function and predict estimated glomerular filtration rate in hypertens…

2008

Numerical and experimental analysis of a pegs-wing ventilated disk brake rotor, with pads and cylinders

2005

The influence of strain rate and presence of dispersed second phases on the deformation behaviour of polycrystalline D2O ice

2018

ABSTRACTThis contribution discusses results obtained from 3-D neutron diffraction and 2-D fabric analyser in situ deformation experiments on laboratory-prepared polycrystalline deuterated ice and ice containing a second phase. The two-phase samples used in the experiments are composed of an ice matrix with (1) air bubbles, (2) rigid, rhombohedral-shaped calcite and (3) rheologically soft, platy graphite. Samples were tested at 10°C below the melting point of deuterated ice at ambient pressures, and two strain rates of 1 × 10−5 s−1 (fast) and 2.5 × 10−6 s−1 (medium). Nature and distribution of the second phase controlled the rheological behaviour of the ice by pinning grain boundary migratio…

Effect of A Healthy Body Image intervention on risk- and protective factors for eating disorders: A cluster randomized controlled trial

2021

Accepted manuscript version, licensed CC BY-NC-ND 4.0. Objective - To investigate the immediate and 12-months effects of a school-based intervention aiming to reduce risk and enhance protective factors for eating disorder development in high school boys and girls. Method - In total, 4,149 adolescents from 30 high schools were eligible for inclusion and 2,446 consented to participate and were randomly allocated to the Healthy Body Image (HBI) intervention or a control group (classes as usual). The HBI intervention is multicomponent consisting of three workshops targeting body image, social media usage and lifestyle. Linear mixed model and intention-to-treat analyses were applied to investiga…