Search results for "STRESS"
showing 10 items of 6278 documents
High levels of the molecular chaperone Mdg1/ERdj4 reflect the activation state of endothelial cells
2003
Mdg1/ERdj4, a mammalian chaperone that belongs to the HSP40 protein family, has been reported to be located in the endoplasmic reticulum (ER), is induced by ER stress, and protects ER stressed cells from apoptosis. Here we show that under normal physiological conditions, Mdg1/ERdj4 is expressed at various levels in the vasculature due to different activation states of the endothelium. To elucidate the stimuli that induce ER stress and thus upregulate Mdg1/ERdj4, we investigated the effect of several endothelium specific stressors on its expression. Mdg1/ERdj4 mRNA is induced by activated macrophages, by nitric oxide (NO) and heat shock, and during terminal cell differentiation, whereas shea…
The pleiotropic effects of antiplatelet therapies
2019
Percutaneous coronary intervention is the most often used method for coronary revascularization. Stenting restores blood perfusion to ischemic areas, but it also causes mechanical disruption of the atheromatous plaque and the nearby endothelium, stimulating the activation of platelets. In a similar way, platelets are activated by thrombin exposure in the setting of plaque rupture. The interaction between platelets, oxidative stress and inflammation is an important factor determining the extent and severity of vascular dysfunction observed in these settings. Platelets activated by the vessel trauma release inflammatory and mitogenic mediators into the vascular microenvironment, activating le…
Numerical Simulations of the Hydrodynamics of the Abdominal Aorta Aneurysm (AAA) Using a Smoothed Particle Hydrodynamics Code with Deformable Wall Pr…
2018
We present some preliminary results of the numerical simulations of the hydrodynamic characteristics of an abdominal aorta aneurysm (AAA) patient specific test case. Images of the AAA lumen have been acquired in 10 discrete time-steps through a stabilized cardiac cycle by electrocardiogram-gated computer tomography angiography, and are used to approximate the in vivo, time dependent kinematic fields of the (internal) arterial wall. The flow field is simulated by a Smoothed Particle SPH numerical model, where the kinematics of the boundary of the computational domain (the internal aortic vessel) is the one computed by the above procedure. The outputs of the SPH model, i.e., pressure and flow…
Residual Stresses due to High Temperature Annealing. Mathematical Model and Calculations
2006
The mathematical model is developed for description of thermomechanical processes at cooling during high temperature annealing with the known initial temperature distribution (the temperature of holding) and stresses (acquired stresses at the final of a holding). It is taken into account the thermal sensitivity and material hardening at elasto-plastic solid deforming. The methodology based on the finite element method is proposed for solving thermomechanics problems of wide range. The suitable software is developed. At the final stage of annealing a cylindrical solid it is investigated residual stresses being formed on the cooling stage.
Determination of Nonuniform Residual Stresses Using the Ring-Core Method
1996
This paper considers residual stress analysis using the ring-core method. In particular, the so-called integral equation method is applied to evaluate nonuniform residual stress fields. The proposed method overcomes typical drawbacks of the incremental strain method which lead to incorrect results for strongly varying stress fields. The experimental results obtained with a specimen subjected to a bending load confirm the theoretical predictions.
KNOWN RESIDUAL STRESS SPECIMENS USING OPPOSED INDENTATION
2009
In order to test new theories for residual stress measurement or to test the effects of residual stress on fatigue, fracture, and stress corrosion cracking, a known stress test specimen was designed and then fabricated, modeled, and experimentally validated. To provide a unique biaxial stress state, a 60 mm diameter 10 mm thick disk of 316L stainless steel was plastically compressed through the thickness with an opposing 15 mm diameter hard steel indenters in the center of the disk. For validation, the stresses in the specimen were first mapped using time-of-flight neutron diffraction and Rietveld full pattern analysis. Next, the hoop stresses were mapped on a cross section of two disks usi…
Influence of correlations between stresses on calculated fatigue life of machine elements
1996
The correlation between components of the random stress tensor and its influence on the calculated fatigue life of machine elements were analysed. Three covariance matrices of components of biaxial stress state were considered. They were determined from measurements of strains in an element of a vibrating screen for aggregate, in the back wall of a bus, and in a welded element of excavator fittings. Calculations were made according to four criteria of multiaxial random fatigue. Cycles were counted with the rainflow method, and damage was cumulated with the Palmgren-Miner hypothesis. It was found that convariances of random stress state components strongly influence the calculated fatigue li…
Bending-Shear interaction domains for externally prestressed concrete girders
2013
In prestressed concrete structures, the evaluation of the safety level is generally carried out by separating the bending moment strength and the shear force capacity. Actually interaction between bending moment (M) and shear force (V) can have significant consequences on evaluations in service life, especially when the ultimate limit state (ULS) is considered. In this paper, the M-V interaction is addressed for prestressed concrete girders, in the cases of both bonded and unbonded prestressing tendons. It can be demonstrated, by drawing the interaction domains (M-V), that a significant reduction of the safety level has to be considered when shear force is evaluated together with bending mo…
An Analytical Tire Model with Flexible Carcass for Combined Slips
2014
Published version of an article in the journal: Mathematical Problems in Engineering. Also available from the publisher at: http://dx.doi.org/10.1155/2014/397538 The tire mechanical characteristics under combined cornering and braking/driving situations have significant effects on vehicle directional controls. The objective of this paper is to present an analytical tire model with flexible carcass for combined slip situations, which can describe tire behavior well and can also be used for studying vehicle dynamics. The tire forces and moments come mainly from the shear stress and sliding friction at the tread-road interface. In order to describe complicated tire characteristics and tire-roa…
Increasing the Capacity of Existing Bridges by Using Unbonded Prestressing Technology: A Case Study
2014
External posttensioning or unbonded prestressing was found to be a powerful tool for retrofitting and for increasing the life extension of existing structures. Since the 1950s, this technique of reinforcement was applied with success to bridge structures in many countries, and was found to provide an efficient and economic solution for a wide range of bridge types and conditions. Unbonded prestressing is defined as a system in which the post-tensioning tendons or bars are located outside the concrete cross-section and the prestressing forces are transmitted to the girder through the end anchorages, deviators, or saddles. In response to the demand for a faster and more efficient transportati…