Search results for "STRESS"

Aplidin® induces JNK-dependent apoptosis in human breast cancer cells via alteration of glutathione homeostasis, Rac1 GTPase activation, and MKP-1 ph…

2006

Aplidin® is an antitumor agent in phase II clinical trials that induces apoptosis through the sustained activation of Jun N-terminal kinase (JNK). We report that Aplidin® alters glutathione homeostasis increasing the ratio of oxidized to reduced forms (GSSG/GSH). Aplidin® generates reactive oxygen species and disrupts the mitochondrial membrane potential. Exogenous GSH inhibits these effects and also JNK activation and cell death. We found two mechanisms by which Aplidin® activates JNK: rapid activation of Rac1 small GTPase and downregulation of MKP-1 phosphatase. Rac1 activation was diminished by GSH and enhanced by L-buthionine (SR)-sulfoximine, which inhibits GSH synthesis. Downregulatio…

Physical inactivity increases oxidative stress, endothelial dysfunction, and atherosclerosis.

2005

Objective— Sedentary lifestyle is associated with increased cardiovascular events. The underlying molecular mechanisms are incompletely understood. Reactive oxygen species (ROS) contribute to endothelial dysfunction and atherosclerosis. An important source of vascular ROS is the NADPH oxidase. Methods and Results— C57BL6 mice were subjected to regular housing (physical inactivity) or voluntary training on running wheels (6 weeks). Inactivity increased vascular lipid peroxidation to 148±9% and upregulated superoxide release to 176±17% (L-012 chemiluminescence) and 188±29% (cytochrome C reduction assay), respectively. ROS production was predominantly increased in the endothelium and the medi…

Exploring early adolescents’ stressful IT use experiences

2022

Early adolescents are accustomed to using information technology (IT) for different purposes as a part of their everyday life. While IT use can provide many benefits, it can also include negative experiences, such as feelings of stress (i.e. technostress). Considering that young IT users’ technostress perspectives have remained limited in the literature, this paper attempts to contrast their experiences with aspects from earlier research. A qualitative content analysis of semi-structured interviews with 31 primary and secondary school students reveals that early adolescents have encountered stressful IT use experiences that vary based on the degree of stress. The experiences relate to diffe…

Tapaustutkimus neljän eri rasitustavan vaikutuksista mielialaan, kognitiiviseen suorituskykyyn ja stressihormoneihin

2003

Psychosocial factors affecting employees of clean room work environments during Covid-19 infection

2021

Psihosociālie faktori tīro telpu darba vidē strādājošajiem Covid-19 infekcijas laikā. Darba autore: Ilze Kaugija. Darba zinātniskais vadītājs: Dr.ķīm. Ingars Reinholds. Darbs uzrakstīts uz 75 lpp., 23 ietver attēlus, 12 tabulas, 75 informatīvos avotus. Pētījuma tēzes sastāv no 4 daļām. Pirmā daļa ietver literatūras analīzi par tīrajām telpām, psihosociālajiem riska faktoriem, saslimšanām un attiecīgajiem normatīvajiem aktiem un Covid-19 pandēmijas ietekmi uz darba vidi. Otrajā daļā aprakstītas pētījumā izmantotās metodes: psiholoģiskā klimata darba vidē novērtēšanas metode, Cox un A. Griffith tests, K. Maslačas emocionālās izdegšanas aptauja, depresijas tests un Č.D. Spīlbergera trauksmes a…

Antioxidant Therapies and Oxidative Stress in Friedreich´s Ataxia: The Right Path or Just a Diversion?

2020

Friedreich's ataxia is the commonest autosomal recessive ataxia among population of European descent. Despite the huge advances performed in the last decades, a cure still remains elusive. One of the most studied hallmarks of the disease is the increased production of oxidative stress markers in patients and models. This feature has been the motivation to develop treatments that aim to counteract such boost of free radicals and to enhance the production of antioxidant defenses. In this work, we present and critically review those 'antioxidant' drugs that went beyond the disease's models and were approved for its application in clinical trials. The evaluation of these trials highlights some …

The Role of Work-Nonwork Boundary Management in Work Stress Recovery

2016

The aim of the present study conducted among 1,106 Finnish employees was to identify boundary management profiles based on cross-role interruption behaviors from work to nonwork and from nonwork to work. Adopting a person-oriented approach through latent profile analysis, 5 profiles were identified: Work Guardians (21% of the employees), Nonwork Guardians (14%), Integrators (25%), Separators (18%), and an Intermediate Group (22%). We then examined differences between these profiles with respect to recovery experiences (psychological detachment from work, relaxation, mastery experiences, and control during off-job time) and recovery outcomes (vigor and exhaustion). Work Guardians had the poo…

Plasma redox response of Sicilian Opuntia Ficus Indica juice in young physically active women.

2017

It is known amateur female athletes show an altered redox status [1] and the consumption of Opuntia Ficus Indica (OFI) decreases oxidative stress (OS) in healthy humans [2]. Therefore, the aim of this study was to investigate whether the supplementation with Sicilian OFI juice affected plasma redox balance following a maximal effort test in young physically active women
 . This study was randomized, double blind, placebo controlled and crossover design. Eight women (23.25±2.95 years old, weight of 54.13±9.05 kg, height of 157.75±0.66 cm and BMI of 21.69±0.66 kg/m2) were randomly divided into 2 groups and each group was supplied with either 50 ml OFI, diluted to 170 ml with water, or 170 ml …

Moderate overexpression of glucose-6-phosphate dehydrogenase improves healthspan in mice. Implications in skeletal muscle regeneration

2019

An enormous increment in the average lifespan of diverse populations occurred worldwide in the 20th century. In the last 10–15 years, the importance has changed from extending average and even maximal longevity to favoring healthy aging, and many researchers have focused their studies on the aim at extending healthspan. Prolonging lifespan without taking care of improving healthspan can derive in a long time of living with disabilities and constitutes a risk factor for the old population to suffer a higher prevalence of aging-related diseases. Indeed, modern disease treatments frequently diminish mortality without any effect on the deterioration of overall health. Understanding the mechanis…

Affect self-regulation through music

2018

The present dissertation focused on musical affect regulation, i.e. on the use of music to self-regulate affective states such as emotions, moods, and energy levels. In publication I, relevant findings from previous research were extracted and the field’s conceptual clarity and precision was assessed. Besides identifying weaknesses in conceptualization and providing recommendations for future studies, publication I found that not all the elements of affect regulation through music have been equally explored by research. Given the gap observed on the study of musical mechanisms underlying affect regulation, publication II placed a special focus on this component and its association with regu…