Search results for "STZ"
showing 10 items of 19 documents
Very low doses of muscimol and baclofen ameliorate cognitive deficits and regulate protein expression in the brain of a rat model of streptozocin-ind…
2018
Recent studies devoted to neuroprotection have focused on the role of the gamma-aminobutyric acid (GABA) system in regulating neuroinflammatory processes which play a key role in the neurodegenerative processes observed in Alzheimer's disease (AD) by inducing glial cell overactivation and impairing neurotransmission. Data on the efficacy of classical GABA-A and GABA-B receptor agonists (muscimol and baclofen, respectively) in animal models of AD are not available. Moreover, no published studies have examined the ability of optimal doses of these compounds to prevent neuroinflammation, the alterations in neurotransmission and cognitive deficits. In the present study, we used a non-transgenic…
PORCN mutations in focal dermal hypoplasia: coping with lethality.
2009
Contains fulltext : 81709.pdf (Publisher’s version ) (Closed access) The X-linked dominant trait focal dermal hypoplasia (FDH, Goltz syndrome) is a developmental defect with focal distribution of affected tissues due to a block of Wnt signal transmission from cells carrying a detrimental PORCN mutation on an active X-chromosome. Molecular characterization of 24 unrelated patients from different ethnic backgrounds revealed 23 different mutations of the PORCN gene in Xp11.23. Three were microdeletions eliminating PORCN and encompassing neighboring genes such as EBP, the gene associated with Conradi-Hunermann-Happle syndrome (CDPX2). 12/24 patients carried nonsense mutations resulting in loss …
Mosaicism due to postzygotic mutations in women with focal dermal hypoplasia
2019
International audience; Focal dermal hypoplasia (FDH, Goltz syndrome, MIM: #305600) constitutes a rare multisystem genetic disorder of the skin, skeleton, teeth and eyes with considerable variation in the clinical features. FDH is transmitted as an X-linked dominant trait and is caused by mutations in PORCN. In males, hemizygous PORCN mutations are lethal in utero. Around 300 cases have been reported in the literature to date. About 10% of them are males presenting either Klinefelter syndrome (karyotype 47, XXY) or mosaicism of a postzygotic mutation. Here we describe four cases of women with typical features of FDH, in whom a PORCN mutation was found in DNA from affected cutaneous tissue b…
Cutaneous mosaic syndromes associated with early postzygotic activating BRAF mutations
2017
IF 3.528; International audience
Nanovised Control Flow Attestation
2022
This paper presents an improvement of control flow attestation (C-FLAT) for Linux. C-FLAT is a control attestation system for embedded devices. It was implemented as a software executing in ARM’s TrustZone on bare-metal devices. We extend the design and implementation of C-FLAT through the use of a type 2 Nanovisor in the Linux operating system. We call our improved system “C-FLAT Linux”. Compared to the original C-FLAT, C-FLAT Linux reduces processing overheads and is able to detect the SlowLoris attack. We describe the architecture of C-FLAT Linux and provide extensive measurements of its performance in benchmarks and real-world scenarios. In addition, we demonstrate the…
Exonic Mosaic Mutations Contribute Risk for Autism Spectrum Disorder
2017
AbstractGenetic risk factors for autism spectrum disorder (ASD) have yet to be fully elucidated. Postzygotic mosaic mutations (PMMs) have been implicated in several neurodevelopmental disorders and overgrowth syndromes. We systematically evaluated PMMs by leveraging whole-exome sequencing data on a large family-based ASD cohort, the Simons Simplex Collection. We found evidence that 11% of published single nucleotide variant (SNV)de novomutations are potentially PMMs. We then developed a robust SNV PMM calling approach that leverages complementary callers, logistic regression modeling, and additional heuristics. Using this approach, we recalled SNVs and found that 22% ofde novomutations like…
Skaitļu atpazīšana brīvā dabā uzņemtās fotogrāfijās
2022
Palielinoties digitālo tehnoloģiju lomai cilvēku ikdienā, OCR jeb Optiskā teksta pazīšana kļūst arvien biežāk izmantota. OCR pielietojumu iespējas ir plašas – kā vienu no biežāk izmantotajām var minēt dokumentu digitalizēšanu – tomēr brīvā dabā uzņemtās fotogrāfijās ar skaitļiem OCR precizitātei vēl joprojām ir vieta izaugsmei. Darba mērķis ir noteikt, cik liela loma un ietekme ir OCR tehnoloģijām mūsdienās un kāpēc tās efektivitāte krīt, analizējot attēlus ar skaitļiem. Darba uzdevumi ietver iepazīšanos ar OCR tehnoloģijas vēsturi un pielietojumiem mūsdienās, tehnoloģijas algoritmiem un trūkumiem tajos. Darba pētījumā tika izpētīti divi OCR rīki, izmantojot programmēšanas valodu Python, un…
Embryotoxic potential of persistent organic pollutants extracted from tissues of guillemots (Uria aalge) from the Baltic Sea and the Atlantic Ocean
2002
The Baltic Sea is a heavily polluted area. To assess the current contaminant pressure on the common guillemot (Uria aalge) living there, whole-body extracts of guillemots from the Baltic Sea were prepared and subdivided over six fractions, which differed in composition due to lipophilicity and polarity of the contaminants. The fractions were tested in the chicken embryo assay and compared to fractions of Atlantic guillemot extracts. Fertilized chicken eggs were injected with 0.03, 0.3, or 3 bird egg equivalents (BEQ) of the contaminants present in the fractions and then incubated for 19 d. Endpoints were selected to cover several mechanisms that may play a role in reproductive failures of f…
Rosyjska koncepcja Eurazjatyckiego Systemu Obrony Powietrzno-Kosmicznej. Analiza problemu
2018
Autorka artykułu omawia na tle uwarunkowań geopolitycznych Rosji najważniejsze tezy planu A. Podbieriezkina, które tworzą paradygmat wspólnego bezpieczeństwa w ujęciu rosyjskim na strategicznym obszarze Eurazji. Ma to szczególne znaczenie w obliczu wzrastających zagrożeń współczesnego świata. Szczególnie niebezpieczny charakter, w związku z przeprowadzaniem prób jądrowych i nieobliczalnym reżimem Kim Dzong Una, przybiera obecnie problem Korei Północnej, co rodzi zagrożenie, że nagły i. ARTYKUŁY i rozprawy 85 konflikt może wciągnąć Półwysep w wojnę. To z kolei z pewnością doprowadziłoby do interwencji Stanów Zjednoczonych. Skutki ewentualnego konfliktu z udziałem supermocarstwa są nie do prz…
Per un'"Economia d'azienda" postzappiana. Appunti storici
2017
Il paper intende concorrere ad una ricostruzione in prospettiva storica dei percorsi di nascita, specificazione e rifondazione dell’Economia di azienda. In particolare, esso evidenzia come tale disciplina abbia prediletto in via di principio l’interpretazione dell’azienda in termini di genere, ma altresì come abbia realizzato in via di fatto, nelle opere di Zappa e della più parte dei suoi allievi diretti ed indiretti, un modello dell’azienda in termini di specie. Nel complesso, la disamina di alcune posizioni nel passato e nel presente storico depongono a favore di un ripensamento dei contenuti disciplinari in prospettiva propriamente “postzappiana” che possa essere di maggiore ed attuale …