Search results for "SUBSTANCES"

showing 10 items of 1122 documents

Methionine in a protein hydrophobic core drives tight interactions required for assembly of spider silk

2019

Web spiders connect silk proteins, so-called spidroins, into fibers of extraordinary toughness. The spidroin N-terminal domain (NTD) plays a pivotal role in this process: it polymerizes spidroins through a complex mechanism of dimerization. Here we analyze sequences of spidroin NTDs and find an unusually high content of the amino acid methionine. We simultaneously mutate all methionines present in the hydrophobic core of a spidroin NTD from a nursery web spider’s dragline silk to leucine. The mutated NTD is strongly stabilized and folds at the theoretical speed limit. The structure of the mutant is preserved, yet its ability to dimerize is substantially impaired. We find that side chains of…

congenital hereditary and neonatal diseases and abnormalitiesProtein Foldinggenetic structuresProtein ConformationScienceSilkmacromolecular substancesCircular dichroismcomplex mixturesArticleMethionineddc:590ddc:570AnimalsAmino Acid Sequencelcsh:ScienceFluorescence spectroscopySequence Homology Amino AcidfungiQtechnology industry and agricultureSpidersSpectrometry FluorescenceMutationThermodynamicslcsh:QProtein MultimerizationFibroinsSolution-state NMRHydrophobic and Hydrophilic InteractionsAlgorithmsNature Communications
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ChemInform Abstract: Tuning the Band Gap of PbCrO4Through High-Pressure: Evidence of Wide-to-Narrow Semiconductor Transitions.

2014

Commercial polycrystalline and cleaved platelets from natural PbCrO4 are studied in a diamond anvil cell at ≤ 21 GPa.

congenital hereditary and neonatal diseases and abnormalitiesbusiness.industryBand gapChemistryA diamondmacromolecular substancesGeneral MedicineSemiconductorstomatognathic systemhemic and lymphatic diseasesHigh pressureparasitic diseasesOptoelectronicsCrystallitebusinessChemInform
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Identification of microbial taxa involved in cultural heritage deterioration and able to produce health hazardous substances by molecular techniques.

2008

Fungi and bacterial, wide-spread in biosphere environments, are the main microorganisms related to the deterioration of cultural assets but, moreover, complex microbial communities may emit mixed aerosol into indoor air. In this study the microbial colonization is investigated from to point of view, conservation of cultural heritage and related potential illness to visitors or professionals. The sampling was performed by non-destructive procedures on works of art surfaces, and by the gelatin membrane filter method (Sartorius) for aerosol. The identification of microbial taxa was performed by molecular analyses based on PCR, sequencing, sequence comparison techniques and, particularly for fu…

detection molecular techniques health hazardous substances biodeteriorationSettore BIO/11 - Biologia Molecolare
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AMATEUR DOPING: A SURVEY AMONG SICILIAN PEOPLE

2018

In last years, Amateur Doping has caused many victims. In order to know the diffusion of this phenomenon, we have conducted an online-survey through Google forms. We also transformed the same questionnaire on paper and it was administered in many gyms in Palermo and Trapani (Sicily-Italy). The sample examined consists of 976 people aged between 14 and 65 (47.3% of them are women and 52.7% are men). We asked them if they ever took on substances to improve their athletic performances: 25.8% of them answered affirmatively and they declared to take on protein, amino acids but also Eca Stacks, which are hired on regular basis (34.6%). They bought this substances in sporting stores (32.2%), in ph…

doping substancesDopingSettore BIO/14 - Farmacologia
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Efficient photoinduced electron transfer in a porphyrin tripod-fullerene supramolecular complex via pi-pi interactions in nonpolar media.

2010

A novel porphyrin tripod (TPZn(3)) was synthesized via "click chemistry". Three porphyrin moieties of TPZn(3) are geometrically close and linked by a flexible linker. The electron-transfer oxidation of TPZn(3) results in intramolecular pi-dimer formation between porphyrin moieties as indicated by electrochemical, vis-NIR, and ESR measurements. The cyclic voltammogram of TPZn(3) exhibited stepwise one-electron oxidation processes of three porphyrin moieties in the range from 0.58 to 0.73 V (vs SCE in CH(2)Cl(2)). When TPZn(3) was oxidized by tris(2,2'-bipyridyl)-ruthenium(III) ([Ru(bpy)(3)](3+)), the oxidized species (TPZn(3))(n+) (0n/= 3) exhibited a charge resonance band in the NIR region …

dyadFullerenePorphyrinsMacromolecular SubstancesPhotochemistrySupramolecular chemistrycharge-separated state010402 general chemistryPhotochemistry01 natural sciencesBiochemistryCatalysisPhotoinduced electron transferchemistry.chemical_compoundColloid and Surface Chemistry[ CHIM.ORGA ] Chemical Sciences/Organic chemistryMoleculeComputingMilieux_MISCELLANEOUSMolecular Structure[CHIM.ORGA]Chemical Sciences/Organic chemistry010405 organic chemistryTripod (photography)reaction center mimicryGeneral ChemistryPorphyrin0104 chemical sciences[CHIM.THEO]Chemical Sciences/Theoretical and/or physical chemistryZincchemistryIntramolecular forceclick chemistry[ CHIM.THEO ] Chemical Sciences/Theoretical and/or physical chemistryClick chemistryQuantum TheoryFullerenesporphyrinOxidation-ReductionJournal of the American Chemical Society
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Special Issue: Improvements for Resveratrol Efficacy

2017

International audience; Resveratrol is a well-known phenolic stilbene because of its presence in several edible plants and its proposed properties that are beneficial to human health [...].

educationPharmaceutical Sciencemacromolecular substancesResveratrol010402 general chemistry01 natural sciences[ CHIM ] Chemical SciencesAnalytical Chemistrylcsh:QD241-441Human healthchemistry.chemical_compoundlcsh:Organic chemistryStilbenesDrug DiscoveryHumansMedicine[CHIM]Chemical SciencesPhysical and Theoretical ChemistryCyclodextrins010405 organic chemistrybusiness.industryOrganic Chemistryfood and beverages3. Good health0104 chemical sciencesBiotechnologyEditorialn/achemistryResveratrolChemistry (miscellaneous)LiposomesEdible plantsMolecular MedicinebusinessMolecules
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De Flora Valentina, XVII

2018

Several new or rare taxa of vascular plants found in the west of the Valencia region (E of Spain) are here commented

educationUNESCO::CIENCIAS DE LA VIDAfood and beveragesmacromolecular substanceshumanities:CIENCIAS DE LA VIDA [UNESCO]
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De Flora Valentina, XVI

2017

Several new or rare taxa of vascular plants found in the west of the Valencia region (E Spain) are here commented.

educationUNESCO::CIENCIAS DE LA VIDAfood and beveragesmacromolecular substanceshumanities:CIENCIAS DE LA VIDA [UNESCO]
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De flora valentina, XX

2020

Several new or rare taxa of vascular plants found in the west of the Valencia region (E Spain) are here commented.

educationUNESCO::CIENCIAS DE LA VIDAfood and beveragesmacromolecular substanceshumanities:CIENCIAS DE LA VIDA [UNESCO]
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About Overeducation and Mismatching

2020

Evidence from several developed economies has shown that skill mismatch and overeducation are widespread phenomena and that they typically affect about one-third of the higher educated employed population.

education.field_of_studyPopulationEconomicsDemographic economicsmacromolecular substanceseducationAffect (psychology)
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