Search results for "SUBSTANCES"
showing 10 items of 1122 documents
γ2-Adaptin is functioning in the late endosomal sorting pathway and interacts with ESCRT-I and -III subunits.
2010
Abstractγ2-Adaptin is a clathrin adaptor-related protein with unclear physiological function. Previous studies indicated that γ2-adaptin might act within the multivesicular body (MVB) protein-sorting pathway that is central to receptor down-regulation, lysosome biogenesis, and budding of enveloped viruses. Here, we have analyzed the effects of excess and deficit γ2-adaptin on exogenous and endogenous MVB cargoes and on the MVB machinery itself. Foreign cargoes, like retroviral Gags, are entrapped by overexpressed γ2-adaptin in detergent-insoluble polymers and blocked in budding. When viral budding involves MVB/endosomal structures, excess γ2-adaptin acts by accelerating lysosomal Gag destru…
NG2 and GFAP co-expression after differentiation in cells transfected with mutant GFAP and in undifferentiated glioma cells
2020
Introduction: Alexander disease is a rare disorder caused by mutations in the gene coding for glial fibrillary acidic protein (GFAP). In a previous study, differentiation of neurospheres transfected with these mutations resulted in a cell type that expresses both GFAP and NG2. Objective: To determine the effect of molecular marker mutations in comparison to undifferentiated glioma cells simultaneously expressing GFAP and NG2. Methods: We used samples of human glioblastoma (GBM) and rat neurospheres transfected with GFAP mutations to analyse GFAP and NG2 expression after differentiation. We also performed an immunocytochemical analysis of neuronal differentiation for both cell types and dete…
Modelling nanoscale fluid dynamics and transport in physiological flows
1996
The concept of nanotechnology is discussed, and its connection with biomedical engineering is elucidated. For the specific field of nanoscale flow and transport problems of physiological relevance, some typical examples are presented, and their interaction is discussed for some classic biomechanical problems like the flow in arteries with blood-wall coupling. Then, existing computational models are presented and classified according to the length scale of interest, with emphasis on particle-fluid problems. Final remarks address the essential unity of biomedical and engineering behaviour and the possible relevance to small-scale industrial research.
Different Wings Flowfields Interaction on the Wing-Propeller Coupling
1997
A high-portability numerical technique based on the method of free wake analysis (FWA) is described that analyzes the interference between an aircraft propeller and a wing having different planforms and computes the influence of the wing aerodynamic field on the propeller performance. For an isolated propeller and wing, the models employed are based on the FWA and Prandtl theory, respectively. The performance of the propeller in the presence of the wing is related to the wing angle of attack and to the variation of wing circulation and the corresponding induced velocity at the propeller disk. A numerical model, previously and successfully used, was implemented to account for the effects of …
Warehouse threats and loss prevention management in case of fire
2016
Abstract Warehouses play an important role when it comes to the reception, delivery and storage of various types of goods. Due to the complex scenarios that may occur, as well as the heterogeneous nature of goods, warehouses bear a higher risk of accidents. Regardless if we’re taking about removing hassle or standardizing operations we speak the same language: insuring efficiency and increased efficiency leads to smart cost maintenances. In the article hear by we will observe the behavior of different warehouse materials in the case of trigger fired. Starting from the results obtained during the low scale tests and completing the premises with the large scale experiment (warehouse scale), w…
Thermodynamic Interaction Parameters of Tetra-n-undecylcalix[4]resorcinarenes with Selected Solvents Studied by Inverse Gas Chromatography
2004
The basic thermodynamic parameters, characterising intermolecular interactions of tetra-n-undecylcalix[4]resorcinarene and its octaacetate derivative with simple organic solutes, were calculated by using the inverse gas chromatography method. Free energy, enthalpy and entropy of sorption were determined.
Dewaterability of CAS and MBR Sludge: Effect of Biological Stability and EPS Composition
2018
The dewaterability of sludge from two conventional activated sludge (CAS) and three membrane bioreactor (MBR)-based wastewater treatment plants is investigated prior to and after anaerobic digestion. The concentration and composition of extracellular polymeric substances (EPS) mostly affect the dewaterability of all raw sludge samples. Better sludge dewaterability is observed when the concentration of proteins, carbohydrates, uronic acids, and humic acids is below approximately 400, 250, 200, and 40 mg/L, respectively. In contrast, the specific resistance to filtration (SRF) increases in the sludge samples with a higher EPS concentration. The MBR results in a lower EPS production and a uron…
Effect of extended famine conditions on aerobic granular sludge stability in the treatment of brewery wastewater
2017
Results obtained from three aerobic granular sludge reactors treating brewery wastewater are presented. Reactors were operated for 60 d days in each of the two periods under different cycle duration: (Period I) short 6 h cycle, and (Period II) long 12 h cycle. Organic loading rates (OLR) varying from 0.7 kg COD m-3 d-1 to 4.1 kg COD m-3 d-1 were tested. During Period I, granules successfully developed in all reactors, however, results revealed that the feast and famine periods were not balanced and the granular structure deteriorated and became irregular. During Period II at decreased 12 h cycle time, granules were observed to develop again with superior structural stability compared to the…
Humic substances as catalysts in condensation reactions
2001
Humic substances (HS) demonstrate appreciable impact on the rate of the condensation reactions as shown in the example of the reaction between hydrazine and 4-(dimethylamino)-benzaldhyde in an aquatic environment. The catalytic activity of HS has also been demonstrated in Knoevenagel and Claisen-Schmidt reactions for condensation of carbonyl compounds with CH acids. The aquatic fulvic acids are the most active in these reactions. The velocity of the studied reactions also depends on pH, temperature, the concentration and origin of HS used. A possible micellar and acid-base catalysis mechanism in aquatic media has been suggested.
Sorption of humic substances on aquifer material at artificial recharge of groundwater
2003
Experiments in batch equilibrium system were carried out to evaluate the importance of physical and chemical factors determining the sorption efficiency of humic substances (HS) on aquifer material, which has been used for artificial recharge of groundwater (ARG) in drinking water production. Results showed that an increase of the amount of clay in the aquifer material and a decrease of pH in water increased the sorption efficiency. The sorption of higher molecular weight, more hydrophobic and aromatic HS (Aldrich and forest soil humic acids) were greater than the sorption of acidic HS (river fulvic acids), either on the aquifer material or to its representative sorbing phases, clay and org…