Search results for "SUE"
showing 10 items of 5189 documents
Abemaciclib: safety and effectiveness of a unique cyclin-dependent kinase inhibitor
2020
Introduction: The discovery and the clinical availability of novel cyclin-dependent kinases 4 and 6 inhibitors have profoundly changed the therapeutic scenario of metastatic hormone receptor-positive breast carcinoma. Among these inhibitors, abemaciclib can induce potent and sustained cell cycle arrest and immune system stimulation. Areas covered: This review summarizes the safety profile and clinical efficacy data on abemaciclib alone or in combination with aromatase inhibitors or fulvestrant in metastatic hormone receptor-positive breast carcinoma. The management of patients treated with abemaciclib is the object of this paper. Expert opinion: As shown in phase 2 and 3 clinical trials on …
Can the odours modulate salivation? Impact of the nature of the odorant
2015
Introduction :Saliva plays numerous roles in the oral cavity, especially in digestion and taste perception. It is well admitted that tastants are effective stimuli of salivation and that the salivary response (flow and composition) depends on the nature of the tastant. However, the impact of odours on salivation is poorly known and not consensual. Odours are the first chemical signal informing about food palatability before ingestion. In this context, it is necessary to understand if the salivary secretions are modulated in function of this sensory signal. The aim of this study is to compare the salivary flow response after stimulation by different odours having different hedonic values.Mat…
SARS-COV-2 PANDEMIC IN THE MEDITERRANEAN AREA: EPIDEMIOLOGY AND PERSPECTIVES
2020
In December 2019, a disease caused by a novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) was identified in Wuhan, Hubei Province, China. In March 2020, the World Health Organization declared the pandemic due to SARS-CoV-2. At the end of May 2020, SARS-CoV-2 confirmed cases and deaths due to novel Coronavirus disease (COVID-19) were about 6.5 million and 380,000, worldwide. In this commentary the authors argue on the impact of SARS-CoV-2 pandemic in different epidemiological settings within the Mediterranean area, discussing any possible association with higher or lower virus spread according to climatic factors, pollutants, characteristics of general population, and organi…
Alice's Adventures in NEETland. Through the Looking Glass over 20 years
2018
International audience
Study on the effects of the adipose tissue-derived mesenchymal stem cell secretome on the innate inflammatory response
2018
Se ha demostrado que las células madre mesenquimales derivadas de tejido adiposo (MSC) ejercen efectos beneficiosos sobre algunas afecciones inflamatorias, que se han relacionado principalmente con la secreción de factores paracrinos. Por lo tanto, se han investigado las MSC como posibles herramientas terapéuticas para el tratamiento de enfermedades inflamatorias y autoinmunes. El secretoma de las MSC contiene factores solubles y componentes vesiculares conocidos como vesículas extracelulares (EV) que juegan un papel importante en diferentes procesos fisiológicos. En este trabajo, hemos investigado el potencial del medio acondicionado (CM) de ratón de las MSC para modular la respuesta infla…
Do SETA Interventions Change Security Behavior? : A Literature Review
2023
Information security education, training, and awareness (SETA) are approaches to changing end-users’ security behavior. Research into SETA has conducted interventions to study the effects of SETA on security behavior. However, we lack aggregated knowledge on ‘how do SETA interventions influence security behavior?’. This study reviews 21 empirical SETA intervention studies published across the top IS journals. The theoretical findings show that the research has extended Protection Motivation Theory by (1) enhancements to fear appeals; (2) drawing attention to relevance; (3) incorporating temporality; (4) and shifting from intentions to behavior. In terms of behavior, the SETA interventions h…
The Institution of Security Agent: A Comparative Study of Polish and French Laws
2022
In many continental legal systems it was often problematic to grant a security right to an entity separate from the holder(s) of the secured receivables. Such arrangement was especially desired by the parties in complex lending structures with many creditors. To solve this problem various legal solutions have been created in different countries. In Poland and in France the special institution of a security agent has been introduced. Aim of this article is to compare those two regulations. The conclusion is that the French provisions better deals with the challenges posed by the entity separation problem. Security agent, collective security arrangements, entity separation, unity principle, s…
Effects of a School-Based Intervention on Motivation for Out-of-School Physical Activity Participation
2021
Purpose: We tested the effects of an autonomy-supportive intervention in physical education (PE) on high-school students’ autonomous motivation in PE, and their autonomous motivation, intentions, and physical activity (PA) behavior in a leisure time guided by the trans-contextual model. Method: PE classes in two schools were assigned to receive either an autonomy-supportive intervention and/or a control intervention via random allocation by the school. The PE teacher of the school assigned to the autonomy-supportive intervention was trained to provide autonomy support while the PE teacher of the school assigned to the control intervention received no training. Students (N = 256) in all clas…
Infrastructural and Human Factors Affecting Safety Outcomes of Cyclists
2018
The increasing number of registered road crashes involving cyclists during the last decade, and the high proportion of road crashes resulting in severe injuries and fatalities among cyclists constitutes a global issue for community health, urban development, and sustainability. Nowadays, the incidence of many risk factors for road crashes of cyclists remains largely unexplained. Given the importance of this issue, the present study has been conducted with the aim of determining relationships between infrastructural, human factors and safety outcomes of cyclists. Objectives: This study aimed, first, to examine the relationship between key infrastructural and human factors present in cycling,…
Compagnonnage dans la pédagogie audiovisuelle, contribution à "Pierre Guérin, sur les pas de Freinet"
2008
248 pages; Paris, éd. Ibis Presse