Search results for "SUE"
showing 10 items of 5189 documents
Considerations for the Analysis of Small Extracellular Vesicles in Physical Exercise
2020
Physical exercise induces acute physiological changes leading to enhanced tissue cross-talk and a liberation of extracellular vesicles (EVs) into the circulation. EVs are cell-derived membranous entities which carry bioactive material, such as proteins and RNA species, and are important mediators of cell-cell-communication. Different types of physical exercise interventions trigger the release of diverse EV subpopulations, which are hypothesized to be involved in physiological adaptation processes leading to health benefits and longevity. Large EVs (“microvesicles” and “microparticles”) are studied frequently in the context of physical exercise using straight forward flow cytometry approach…
Characterization of a novel three-dimensional outgrowth model of human bronchial mucosa
2011
Recently it has been hypothesized that a reactivation of the epithelial-mesenchymal trophic unit (EMTU) of the respiratory mucosa, caused by extensive epithelial damage, may be responsible for the pathogenesis of asthma. However, most research on this subject so far has been limited by the unavailability of in vitro models correctly mimicking the three-dimensional architecture of the properly differentiated human bronchial mucosa. For this reason, we have developed a novel 3D outgrowth model, obtained from bronchial biopsies and composed of both human bronchial epithelial cells (goblet and columnar cells) and fibroblasts with their basement membrane. Here we present the preliminary data obt…
Pore size graded scaffold for selective cellular permeation
2014
Development of polypeptide-based therapeutics for topical delivery
2019
Topical administration represents the main route to attain local therapeutic activity of bioactive agents in several organs, such as the skin or the heart by means of devices that enhance drug transport through the endothelium acting as a reservoir. The complex structure of the skin protects the human body against potentially harmful external agents; however, this protective mechanism inhibits the penetration of topically administering bioactive agents employed for the treatment of skin diseases. Unfortunately, many of the topical drugs currently used or under evaluation in clinical trials lack the appropriate physico-chemical characteristics required for delivery through the skin. However,…
Peri-Implant Behavior of Tissue Level Dental Implants with a Convergent Neck
2021
Introduction: The aim of this retrospective study was to analyze the radiographic peri-implant bone loss of bone level implants and tissue level implants with a convergent neck in screw-retained single crowns and in screw-retained fixed partial prostheses, after two years of functional loading. Materials and methods: The sample was divided into two groups according to their type: Group I: supracrestal implants with convergent transmucosal neck
Effectos de la precesión del cultivos, gestión de los residuos y dela irrigación en la respuesta bioagronomica y cualitativa del tomate y sobre algun…
2010
Deep transcriptome profile of early host responses to Huanglongbing in citrus fruit and leaf tissues.
2010
The prolyl-isomerase PIN1 is essential for nuclear Lamin-B structure and function and protects heterochromatin under mechanical stress.
2021
Summary: Chromatin organization plays a crucial role in tissue homeostasis. Heterochromatin relaxation and consequent unscheduled mobilization of transposable elements (TEs) are emerging as key contributors of aging and aging-related pathologies, including Alzheimer’s disease (AD) and cancer. However, the mechanisms governing heterochromatin maintenance or its relaxation in pathological conditions remain poorly understood. Here we show that PIN1, the only phosphorylation-specific cis/trans prolyl isomerase, whose loss is associated with premature aging and AD, is essential to preserve heterochromatin. We demonstrate that this PIN1 function is conserved from Drosophila to humans and prevents…
Estudio electroencefalográfico de las alteraciones de vigilia y sueño en ratas sometidas a pesticidas.
2017
Resumen: Introducción: En los últimos años existe una gran preocupación por el aumento de la incidencia de los trastornos del aprendizaje y del desarrollo en niños. Por ejemplo, las tasas de prevalencia del trastorno del espectro autista (TEA) y del trastorno por déficit de atención e hiperactividad (TDAH) parecen ir en aumento en todo el mundo. El uso de sustancias químicas (pesticidas) en agricultura y en el hogar para combatir diferentes plagas no sólo tiene beneficios asociados, sino también una serie de perjuicios a nivel de los ecosistemas y graves consecuencias para la salud humana. Debido a que la mayoría de los pesticidas dirigen su efecto hacia el sistema nervioso de los insectos …
Salud vial: Teoría y prácticas de los trastornos físicos y psíquicos en la conducción.
2008
Hay una gran parte de la población que padece problemas psicológicos como una depresión, la ansiedad o el estrés. Algunos de estos cuadros clínicos psicológicos también se han derivado de las enfermedades físicas padecidas Así que las enfermedades físicas y psíquicas a veces vienen juntas. Por ello, desde un punto de vista práctico, podemos afianzarnos en la idea de que no podemos plantear un divorcio entre lo físico y lo psíquico, aunque esta división teórica nos sirva para tratar de estudiar mejor “el problema”. Está claro que la principal forma de alivio de una enfermedad es a través de un tratamiento, y éste implica en la mayoría de las ocasiones la utilización de fármacos. De los fárma…