Search results for "SUN"
showing 10 items of 935 documents
Correlation between relative sunshine and state of the sky
1981
Abstract It is possible to construct a sunshine map referring to a large zone, lacking in a widespread network of recording stations, correlating the relative sunshine with the “state of the sky”, defined by the monthly mean number of the clear, mixed and overcast days, whose data are more largely available. In the correlation here proposed climatological and meteorological factors are introduced in order to express the helioclimatic characteristics of every location. The application to Italy, using the data of the period 1973–1977 provided by the 31 stations of ITAV, has suggested the classification of these stations in seven “helioclimatic groups” characterized by different values of the …
¿Un ministro para la esperanza? / 1
2004
Lucidez intelectual
2010
La circulación manuscrita de los poemas alfabéticos de Francisco de Osuna: El caso del manuscrito «MSS/74» de la Biblioteca Nacional de España
2013
International audience; A raíz del redescubrimiento en la BNE del manuscrito MSS/74 —una copiosa antología de cartas y opúsculos místicos del siglo xvi—, se pudieron identificar dos de los tres «alfabetos» anónimos al amor de Dios que cierran dicho compendio: se trata en realidad de dos poemas alfabéticos de Francisco de Osuna. Constituyendo un ejemplo inédito de versiones manuscritas de los poemas del franciscano andaluz, estos alfabetos presentan variantes significativas respecto de las versiones impresas procedentes del Segundo y del Cuarto Abecedario espiritual. El cotejo de ambas versiones, y el análisis atento de dichas variantes, evidencian la realidad de una circulación oral y manus…
El llibre de la Çuna e Xara en dos bibliotecas valencianas del siglo XV
2019
Este trabajo estudia la presencia del libro llamado Llibre de la Çuna e Xara, por el que se regían las aljamas musulmanas valencianas durante la Edad Media, en dos bibliotecas valencianas dispares. Una la del noble Ferran Ximénez d’Arenós, señor de Alberic, y la otra de Joan Lopiç, párroco de Silla. En la primera obedece a una mejor ejecución de la jurisdicción civil y criminal entre sus vasallos musulmanes, en la segunda para conseguir una evangelización efectiva de esa población musulmana. This article analyzes the presence of book denominated Llibre de la Çuna e Xarain two Valencian libraries. Muslims are governed by all laws and rules of that book during Medieval Age in the Kingdom of V…
Multiple modes of cell death in neuroendocrine tumors induced by artesunate.
2020
Abstract Background The paucity of effective treatment in neuroendocrine tumors (NETs) encouraged us to investigate the therapeutic value of artesunate (ART) promised by its inhibitory effect against various tumors and broad safety profile. Methods We evaluated the impact of ART on three NET cell lines, BON-1, QGP-1 and NCI-H727 on cellular and molecular levels. Results Our results showed that ART induced endoplasmic reticulum (ER) stress through phosphorylation of eIF2α, which further gave rise to autophagy in all three NET cell lines. Specifically, apoptosis and ferroptosis were also observed in BON-1 cells, which made BON-1 cell line more vulnerable upon ART treatment. The different sens…
Human NK cells selective targeting of colon cancer-initiating cells: a role for natural cytotoxicity receptors and MHC class I molecules
2013
Abstract Tumor cell populations have been recently proposed to be composed of two compartments: tumor-initiating cells characterized by a slow and asymmetrical growth, and the “differentiated” cancer cells with a fast and symmetrical growth. Cancer stem cells or cancer-initiating cells (CICs) play a crucial role in tumor recurrence. The resistance of CICs to drugs and irradiation often allows them to survive traditional therapy. NK cells are potent cytotoxic lymphocytes that can recognize tumor cells. In this study, we have analyzed the NK cell recognition of tumor target cells derived from the two cancer cell compartments of colon adenocarcinoma lesions. Our data demonstrate that freshly p…
Effect of Ultraviolet Irradiation on Biosynthesis of Dna in Guinea-Pig Skin in Vivo
1974
The molecular and metabolic alterations preceding the clinical manifestation of a photobiologic process, the erythematous or sunburn reaction, were investigated in mammalian skin in vivo. The effect of a moderate (2.5–3 times the minimal erythema dose [MED]) and a large (6–8 times MED) dose of ultraviolet radiation (290–320 nm) on the incorporation of [ Me - 3 H]-thymidine into epidermal cell DNA of guinea pigs was studied. The epilated half of the back of each animal was irradiated with various doses of ultraviolet light, and the other half served as the nonirradiated control. The amount of intraperitoneally injected [ Me - 3 H]-thymidine incorporated into the DNA was determined by the iso…
Experimental and theoretical studies on thymine photodimerization mediated by oxidatively generated DNA lesions and epigenetic intermediates.
2020
[EN] Interaction of nucleic acids with light is a scientific question of paramount relevance not only in the understanding of life functioning and evolution, but also in the insurgence of diseases such as malignant skin cancer and in the development of biomarkers and novel light-assisted therapeutic tools. This work shows that the UVA portion of sunlight, not absorbed by canonical DNA nucleobases, can be absorbed by 5-formyluracil (ForU) and 5-formylcytosine (ForC), two ubiquitous oxidatively generated lesions and epigenetic intermediates present in living beings in natural conditions. We measure the strong propensity of these molecules to populate triplet excited states able to transfer th…
The Xícaras from Don Hilarion: the public spaces and private homes in the eighteenth century rural
2012
El inventario post mortem y el libro de cuenta y razón del escribano Hilarión Cardona nos proporcionan una abundante información sobre las formas de vida y las actividades de este singular personaje y de su entorno. A su ascenso económico y social ayudará una estudiada política matrimonial, lo que le permitirá hacerse un hueco destacado entre los miembros de la oligarquía local. Lo nutrido y excepcional de su vestuario, junto con la posesión de novedosos objetos, nada comunes al resto de los inventarios de bienes, nos ofrecen una clara imagen del proceso de trasferencia de las formas de vida entre la ciudad y el medio rural. Hilarión sintetiza la emulación de los hábitos de comportamiento d…