Search results for "SUNA"
showing 10 items of 83 documents
Biblioteca de la Casa de Osuna en la Universidad de Granada
2023
Se pretende dar luz al fondo existente en la Biblioteca de la Universidad de Granada de los libros ingresados de la Casa de Osuna. Existía una parte identificada, pero al no disponer de un listado como otras Universidades, se han tenido que identificar las distintas marcas de procedencia uno a uno, trabajo lento y laborioso. También hemos recogido otras marcas de procedencia de otros poseedores de la Casa de Osuna, con supralibros, dedicatorias, o exlibris impresos y manuscritos.
Tsunami Vulnerability Evaluation for a Small Ancient Village on Eastern Sicily Coast
2022
The Ionian sea is prone to tsunamis due to its proximity to the Calabrian subduction zone, which is one of the major tsunamigenic areas of the Mediterranean. The tsunami disaster risk is, nowadays, significantly higher due to the increased exposure of buildings as a result of the economic and touristic growth of the Mediterranean coastal areas. This study focuses on Marzamemi, a small village in the western coast of Sicily, since its morphology and human presence amplify the need to assess its buildings’ vulnerability. The main objective of this research is to quantify the building vulnerability to tsunami hazards using a physical and realistic tsunami scenario. For this purpose, the relati…
Artesunate derived from traditional Chinese medicine induces DNA damage and repair.
2008
Abstract Artesunate is a semisynthetic derivative from artemisinin, a natural product from the Chinese herb Artemisia annua L. It exerts antimalarial activity, and, additionally, artemisinin and its derivatives are active against cancer cells. The active moiety is an endoperoxide bridge. Its cleavage leads to the formation of reactive oxygen species and carbon-centered radicals. These highly reactive molecules target several proteins in Plasmodia, which is thought to result in killing of the microorganism. DNA damage induced by artemisinins has not yet been described. Here, we show that artesunate induces apoptosis and necrosis. It also induces DNA breakage in a dose-dependent manner as sho…
Development of resistance towards artesunate in MDA-MB-231 human breast cancer cells.
2011
Breast cancer is the most common cancer and the second leading cause of cancer death in industrialized countries. Systemic treatment of breast cancer is effective at the beginning of therapy. However, after a variable period of time, progression occurs due to therapy resistance. Artesunate, clinically used as anti-malarial agent, has recently revealed remarkable anti-tumor activity offering a role as novel candidate for cancer chemotherapy. We analyzed the anti-tumor effects of artesunate in metastasizing breast carcinoma in vitro and in vivo. Unlike as expected, artesunate induced resistance in highly metastatic human breast cancer cells MDA-MB-231. Likewise acquired resistance led to abol…
Artesunate induces oxidative DNA damage, sustained DNA double-strand breaks, and the ATM/ATR damage response in cancer cells.
2011
Abstract Artesunate, the active agent from Artemisia annua L. used in the traditional Chinese medicine, is being applied as a first-line drug for malaria treatment, and trials are ongoing that include this drug in cancer therapy. Despite increasing interest in its therapeutic application, the mode of cell killing provoked by artesunate in human cells is unknown. Here, we show that artesunate is a powerful inducer of oxidative DNA damage, giving rise to formamidopyrimidine DNA glycosylase–sensitive sites and the formation of 8-oxoguanine and 1,N6-ethenoadenine. Oxidative DNA damage was induced in LN-229 human glioblastoma cells dose dependently and was paralleled by cell death executed by ap…
Factors determining sensitivity or resistance of tumor cell lines towards artesunate.
2009
Clinical oncology is still challenged by the development of drug resistance of tumors that result in poor prognosis for patients. There is an urgent necessity to understand the molecular mechanisms of resistance and to develop novel therapy strategies. Artesunate (ART) is an anti-malarial drug, which also exerts profound cytotoxic activity towards cancer cells. We first applied a gene-hunting approach using cluster and COMPARE analyses of microarray-based transcriptome-wide mRNA expression profiles. Among the genes identified by this approach were genes from diverse functional groups such as structural constituents of ribosomes (RPL6, RPL7, RPS12, RPS15A), kinases (CABC1, CCT2, RPL41), tran…
Traditional Chinese medicines (TCMs) for molecular targeted therapies of tumours.
2009
Scientific progress in genetics, cell and molecular biology has greatly ameliorated our comprehensive understanding of the molecular mechanisms of neoplastic transformation and progression. The rapidly advancing identification of molecular targets in human cancers during the last decade has provided an excellent starting point for the development of novel therapeutics. A huge variety of potential molecular targets have been identified, many of which are already in the market for therapeutic purposes. It is now becoming possible to target pathways and/or molecules that are crucial in maintaining the malignant phenotype. Traditional Chinese medicine (TCM) is often considered as alternative or…
La circulación manuscrita de los poemas alfabéticos de Francisco de Osuna: El caso del manuscrito «MSS/74» de la Biblioteca Nacional de España
2013
International audience; A raíz del redescubrimiento en la BNE del manuscrito MSS/74 —una copiosa antología de cartas y opúsculos místicos del siglo xvi—, se pudieron identificar dos de los tres «alfabetos» anónimos al amor de Dios que cierran dicho compendio: se trata en realidad de dos poemas alfabéticos de Francisco de Osuna. Constituyendo un ejemplo inédito de versiones manuscritas de los poemas del franciscano andaluz, estos alfabetos presentan variantes significativas respecto de las versiones impresas procedentes del Segundo y del Cuarto Abecedario espiritual. El cotejo de ambas versiones, y el análisis atento de dichas variantes, evidencian la realidad de una circulación oral y manus…
El llibre de la Çuna e Xara en dos bibliotecas valencianas del siglo XV
2019
Este trabajo estudia la presencia del libro llamado Llibre de la Çuna e Xara, por el que se regían las aljamas musulmanas valencianas durante la Edad Media, en dos bibliotecas valencianas dispares. Una la del noble Ferran Ximénez d’Arenós, señor de Alberic, y la otra de Joan Lopiç, párroco de Silla. En la primera obedece a una mejor ejecución de la jurisdicción civil y criminal entre sus vasallos musulmanes, en la segunda para conseguir una evangelización efectiva de esa población musulmana. This article analyzes the presence of book denominated Llibre de la Çuna e Xarain two Valencian libraries. Muslims are governed by all laws and rules of that book during Medieval Age in the Kingdom of V…
Multiple modes of cell death in neuroendocrine tumors induced by artesunate.
2020
Abstract Background The paucity of effective treatment in neuroendocrine tumors (NETs) encouraged us to investigate the therapeutic value of artesunate (ART) promised by its inhibitory effect against various tumors and broad safety profile. Methods We evaluated the impact of ART on three NET cell lines, BON-1, QGP-1 and NCI-H727 on cellular and molecular levels. Results Our results showed that ART induced endoplasmic reticulum (ER) stress through phosphorylation of eIF2α, which further gave rise to autophagy in all three NET cell lines. Specifically, apoptosis and ferroptosis were also observed in BON-1 cells, which made BON-1 cell line more vulnerable upon ART treatment. The different sens…