Search results for "SVR."

showing 9 items of 19 documents

Hepatic decompensation is the major driver of death in HCV-infected cirrhotic patients with successfully treated early hepatocellular carcinoma

2017

Background & Aims Assessment of long-term outcome is required in hepatitis C virus (HCV)-infected patients with cirrhosis, who have been successfully treated for Barcelona Clinic Liver Cancer (BCLC) stage A hepatocellular carcinoma (HCC). However, problems arise due to the lack of models accounting for early changes during follow-up. The aim of this study was to estimate the impact of early events (HCC recurrence or hepatic decompensation within 12Â months of complete radiological response) on 5-year overall survival (OS) in a large cohort of patients with HCV and cirrhosis, successfully treated HCC. Methods A total of 328 consecutive Caucasian patients with HCV-related cirrhosis and BC…

Liver CirrhosisMaleHepatocellular Carcinoma Liver Cirrhosis hepatitis C virus Survival direct-acting antiviral agentsSurvival rateCirrhosisAntiviral agentGastroenterologyLiver cirrhosi0302 clinical medicineRecurrenceHepatic decompensation; Hepatitis C Virus (HCV); Hepatocellular carcinoma (HCC); Prognosis; Recurrences; Sustained virological response (SVR); overall survival (OS)Overall survivalLiver NeoplasmsHepatitis Coverall survival (OS)Middle AgedPrognosisHepatitis CSustained virological responseLocal030220 oncology & carcinogenesisHepatocellular carcinoma030211 gastroenterology & hepatologyFemaleAntiviral agents; Carcinoma hepatocellular; Hepatic decompensation; Hepatitis C; Hepatocellular carcinoma (HCC); Liver cirrhosis; Overall survival; Prognosis; Recurrences; Survival rate; Sustained virological response; Aged; Carcinoma Hepatocellular; Female; Hepatitis C; Humans; Liver Cirrhosis; Liver Neoplasms; Male; Middle Aged; Neoplasm Recurrence Local; Proportional Hazards ModelsLiver cancerHepatic decompensationmedicine.medical_specialtyCarcinoma HepatocellularPrognosiSettore MED/12 - GASTROENTEROLOGIA03 medical and health scienceshepatocellularInternal medicinemedicineEarly Hepatocellular CarcinomaHumansRecurrencesHepatocellular carcinoma (HCC)Survival rateAntiviral agents; Carcinoma hepatocellular; Hepatic decompensation; Hepatitis C; Hepatocellular carcinoma (HCC); Liver cirrhosis; Overall survival; Prognosis; Recurrences; Survival rate; Sustained virological response; HepatologyAgedProportional Hazards ModelsHepatologybusiness.industryHepatitis C Virus (HCV)CarcinomaHepatocellularHepatologymedicine.diseasedigestive system diseasesNeoplasm RecurrenceAntiviral agentsLiver cirrhosisLiver functionNeoplasm Recurrence LocalbusinessSustained virological response (SVR)
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Early menopause is associated with lack of response to antiviral therapy in women with chronic hepatitis C.

2011

Background & Aims Chronic hepatitis C (CHC) and liver fibrosis progress more rapidly in men and menopausal women than in women of reproductive age. We investigated the associations among menopause, sustained virologic response (SVR), and liver damage in patients with CHC. Methods We performed a prospective study of 1000 consecutive, treatment-naive patients 18 years of age and older with compensated liver disease from CHC. Liver biopsy samples were analyzed (for fibrosis, inflammation, and steatosis) before patients received standard antiviral therapy. From women (n = 442), we collected data on the presence, type, and timing of menopause; associated hormone and metabolic features; serum lev…

Liver CirrhosisMaleTime Factorsmedicine.medical_treatmentBiopsyMenopause PrematuremenopauseHepacivirusmedicine.disease_causeGastroenterologySeverity of Illness IndexRisk FactorsOdds RatioProspective StudiesTreatment FailureProspective cohort studymedicine.diagnostic_testGastroenterologyAge FactorsHormone replacement therapy (menopause)Hepatitis CMiddle AgedViral LoadImmunohistochemistryMenopauseItalyLiver biopsyRNA ViralFemaleInflammation Mediatorshcv svr menopauseViral loadAdultmedicine.medical_specialtyantiviral therapy; menopause; prognostic factors; hcv therapyGenotypeHepatitis C virusAntiviral AgentsRisk AssessmentSex FactorsInternal medicinehcvmedicineHumanshcv; ifn; menopauseHepatologybusiness.industryInterleukin-6Tumor Necrosis Factor-alphaOdds ratioHepatitis C Chronicmedicine.diseaseifnEndocrinologyLogistic ModelsbusinessBiomarkersGastroenterology
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Metabolic comorbidities and male sex influence steatosis in chronic hepatitis C after viral eradication by direct-acting antiviral therapy (DAAs): Ev…

2021

Background: Chronic hepatitis C (CHC) is associated with hepatic steatosis, related to both a direct viral action and metabolic features. Vice-versa data on hepatic steatosis after viral eradication by direct-acting antiviral agents (DAA) are undefined although the presence of metabolic alterations could strongly influence the occurrence of steatosis as in NAFLD. The controlled attenuation parameter (CAP) (FibroscanⓇ) allows the qualitative and quantitative evaluation of fatty liver. Aim: to evaluate in patients with CHC whether hepatic steatosis diagnosed by CAP modifies after DAAs-induced sustained virologic response (SVR). Methods: Data were collected the day of DAAs therapy starting and…

Malemedicine.medical_specialtySustained Virologic ResponseOverweightGastroenterologyAntiviral Agents03 medical and health sciences0302 clinical medicineChronic hepatitisInternal medicineGenotypemedicineHumansDe novo steatosiDAAAgedRetrospective StudiesHypertriglyceridemiaHepatologybusiness.industryFatty liverHypertriglyceridemiaGastroenterologyAntiviral therapyOverweightHepatitis C ChronicMiddle Agedmedicine.diseaseMale sexFatty LiverSVR.Italy030220 oncology & carcinogenesisHCV030211 gastroenterology & hepatologyFemalemedicine.symptomSteatosisbusinessDirect actingDigestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
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Pegylated interferon α plus ribavirin for the treatment of chronic hepatitis C: A multicentre independent study supported by the Italian Drug Agency

2014

a b s t r a c t Background: Data on the efficacy of Peg-interferon/ribavirin therapy for chronic hepatitis C are mostly derived from treatment of selected patients enrolled in clinical trials. This study aimed to assess the effectiveness of Peg-interferon/ribavirin therapy in “real world” chronic hepatitis C patients in Italy. Methods: Independent observational multicentre study including consecutive patients receiving Peginterferon/ribavirin in the 18 months before (retrospective phase) and after (prospective phase) the start of the study. Results: 4176 patients were eligible. The final study population consisted of 2051 patients in the retrospective and 2073 in the prospective phase. Sust…

RegistrieMaleCirrhosismedicine.disease_causePolyethylene GlycolGastroenterologyPolyethylene Glycolschemistry.chemical_compoundHepatitis VirusesHepatitis ViruseProspective StudiesViralRegistriesChronicProspective cohort studyDrug CarrierDrug CarriersSettore MED/12 - GastroenterologiaMedicine (all)GastroenterologyRecombinant ProteinMiddle AgedHepatitis CRecombinant ProteinsTreatment OutcomeItalyCombinationRNA ViralPopulation studyDrug Therapy CombinationFemaleHumanmedicine.medical_specialtyGenotypeHepatitis C virusAlpha interferonRibavirin; Sustained virological response (SVR); TreatmentAntiviral AgentsFollow-Up StudieRibavirin; Sustained virological response (SVR); Treatment; Hepatology; GastroenterologyDrug TherapyInternal medicineRibavirinmedicineHumansAntiviral AgentHepatologybusiness.industryRibavirinInterferon-alphaHCV therapyHepatitis C ChronicHepatologymedicine.diseaseClinical trialTreatmentProspective StudiechemistryImmunologyRNARibavirin; Sustained virological response (SVR); Treatment; Antiviral Agents; Drug Carriers; Drug Therapy Combination; Female; Follow-Up Studies; Genotype; Hepatitis C Chronic; Hepatitis Viruses; Humans; Interferon-alpha; Italy; Male; Middle Aged; Polyethylene Glycols; Prospective Studies; RNA Viral; Recombinant Proteins; Ribavirin; Treatment Outcome; RegistriesbusinessRibavirin; Sustained virological response (SVR); Treatment; Antiviral Agents; Drug Carriers; Drug Therapy Combination; Female; Follow-Up Studies; Genotype; Hepatitis C Chronic; Hepatitis Viruses; Humans; Interferon-alpha; Italy; Male; Middle Aged; Polyethylene Glycols; Prospective Studies; RNA Viral; Recombinant Proteins; Ribavirin; Treatment Outcome; Registries; Gastroenterology; Hepatology; Medicine (all)Follow-Up StudiesSustained virological response (SVR)
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COMPUTER ASSISTED IMAGE ANALYSIS OF LIVER COLLAGEN: RELATIONSHIP TO ESOPHAGEAL VARICES, LIVER DECOMPENSATION AND SVR IN PATIENTS WITH COMPENSATED HCV…

2011

SVRLIVER DECOMPENSATIONHCV CIRRHOSISESOPHAGEAL VARICES
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PEG-INTERFERON PLUS RIBAVIRIN IN COMPENSATED HCV CIRRHOSIS WITH PORTAL HYPERTENSION: THE ROLE OF RAPID AND EARLY VIROLOGICAL RESPONSE IN PREDICTING T…

2009

Settore MED/12 - GastroenterologiaSettore MED/07 - Microbiologia E Microbiologia ClinicaPEG IFN/RBV HCV Cirrhosis SVR EVRHCV PEG-Interferon plus Ribavirin Rapid virological response
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Sociālo mediju ziņojumu ietekme uz digitālo aktīvu cenu veidošanos: ekonometriskā analīze.

2022

Darba mērķis ir novērtēt Reddit platformas sentimentu, pirmkārt, noskaidrot vai tas statistiski nozīmīgi ietekmē digitālo aktīvu Decentraland, Tezos vai Chiliz vērtību. Otrkārt, noteikt vai sociālo mediju ietekme atšķiras šiem neaizvietojamajiem tokeniem un kriptovalūtai Ethereum. Pētījums veikts par 2021. gada Reddit platformā publicētajiem ziņojumiem. Tāpat analīzei tika lejuplādēti digitālo aktīvu Decentraland, Tezos, Chiliz un Ethereum monētu tirgus dienas dati no Yahoo! Finance tīmekļa vietnes, tādējādi iegūstot 361 gadījumu par katru no aktīviem. Ziņojumu polaritātes noteikšanai tika izmantots VADER klasifikators. Ar lineāras regresijas palīdzību tika novērtēts, vai pastāv attiecības …

VADERatbalsta vektoru regresija (SVR)Ekonomikalineārā regresijasociālo mediju sentimentsneaizvietojamie tokeni (NFT)
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Alcohol and Cannabis Consumption Does Not Diminish Cure Rates in a Real-World Cohort of Chronic Hepatitis C Virus Infected Patients on Opioid Substit…

2019

Background: The importance of alcohol and cannabis consumption for the effectiveness of treatment of chronic hepatitis C virus (HCV) infection with direct acting antivirals (DAAs) in people on opioid substitution therapy (OST) has not been investigated in detail. Methods: We investigated sustained virological response (SVR) rates and proportion of lost to follow-up (LTFU) between OST (n = 739) and non-OST patients (n = 7008) in the German Hepatitis C-Registry (Deutsches Hepatitis C-Register, DHC-R), which is a national multicenter prospective non-interventional real-world registry. Non-OST patients comprised patients with former/current drug use (non-OST/DU; n = 1500) and patients never con…

cannabismedicine.medical_specialtyMedizinShort ReportAlcoholVirus03 medical and health scienceschemistry.chemical_compound0302 clinical medicineChronic hepatitisInternal medicinereal-world settingmedicine030212 general & internal medicinePWIDConsumption (economics)biologyOSTbusiness.industryalcohollcsh:Public aspects of medicinefungilcsh:RA1-1270Hepatitis Cbiology.organism_classificationmedicine.diseaseSVR12Psychiatry and Mental healthchemistryCohortHCV030211 gastroenterology & hepatologyCannabisbusinessOpioid substitution therapySubstance abuse : research and treatment
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Evaluación y predicción de la reincidencia en agresores sexuales argentinos: el svr20

2015

En este estudio se revisan tanto las teorías y conocimientos existentes sobre etiología y factores de riesgo de agresión sexual, como algunas investigaciones internacionales y españolas que sustentan estos conocimientos. Su principal objetivo es la presentación de un nuevo instrumento de predicción en este campo denominado SVR-20: Manual de valoración del riesgo de violencia sexual. Para su validación se ha efectuado un primer estudio exploratorio sobre la capacidad predictiva del SVR-20 con una muestra de 42 agresores sexuales argentinos que cumplen condena en dos prisiones de Mendoza. Se realizó un estudio retrospectivo y la regresión logística binaria y la curva ROC ofrecen resultados sa…

valoracion del riesgo:svr20violencia sexualreincidencia delictiva:PSICOLOGÍA [UNESCO]delincuencia violentaUNESCO::PSICOLOGÍAagresores sexuales argentinossvr20 [valoracion del riesgo]
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