Search results for "SYK"

Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder

2018

Psychiatric disorders are thought to have a complex genetic pathology consisting of interplay of common and rare variation. Traditionally, pedigrees are used to shed light on the latter only, while here we discuss the application of polygenic risk scores to also highlight patterns of common genetic risk. We analyze polygenic risk scores for psychiatric disorders in a large pedigree (n ~ 260) in which 30% of family members suffer from major depressive disorder or bipolar disorder. Studying patterns of assortative mating and anticipation, it appears increased polygenic risk is contributed by affected individuals who married into the family, resulting in an increasing genetic risk over generat…

“Symptoms associated with environmental factors” (SAEF) – Towards a paradigm shift regarding “idiopathic environmental intolerance” and related pheno…

2020

Health conditions characterized by symptoms associated with chemical, physical and biological environmental factors unrelated to objectifiable pathophysiological mechanisms are often labelled by the general term “idiopathic environmental intolerances”. More specific, exposure-related terms are also used, e.g. “multiple chemical sensitivities”, “electromagnetic hypersensitivity” and “candidiasis hypersensitivity”. The prevalence of the conditions varies from a few up to more than 50%, depending on definitions and populations. Based on evolving knowledge within this field, we provide arguments for a paradigm shift from terms focusing on exposure and intolerance/(hyper-)sensitivity towards a t…

Family involvement in the intensive care unit in four Nordic countries

2021

BackgroundRelevance to clinical practice The findings from the study highlighting family involvement, high-quality communication and flexible visiting policy as central aspects of family care may inspire clinicians to identify aspects of everyday family care in their ICUs calling for further improvement.Aims and objectivesTo describe family involvement, communication practices and visiting policies in adult ICUs.DesignA cross-sectional survey.MethodA questionnaire consisting of 11 sections was developed, pilot tested and e-mailed to 196 ICUs. The participants were intensive care nurses in adult ICUs in four Nordic countries.ResultsThe survey was conducted in October to December 2019. The re…

Ion source and low energy beam transport prototyping for a single-ended heavy ion ToF-ERDA facility

2023

We present the status of the ion source and low energy beam transport prototyping activities for a heavy ion time-of-flight elastic recoil detection analysis (ToF-ERDA) equipment, designed to accelerate a flux of 1–10 particle nano-Ampere of 40Ar6-12+ ions to 3–6 MeV energy for depth profiling of light elements. The prototype injector consists of a novel permanent magnet electron cyclotron resonance ion source CUBE-ECRIS with a minimum-B quadrupole field topology, and a 90° permanent magnet dipole with adjustable field strength for charge state selection. We report experimentally measured argon beam currents as a function of the applied microwave power and ion source potential to demonstrat…

Study of radial motion phase advance during motion excitations in a Penning trap and accuracy of JYFLTRAP mass spectrometer

2021

Phase-imaging ion-cyclotron-resonance technique has been implemented at the Penning-trap mass spectrometer JYFLTRAP and is routinely employed for mass measurements of stable and short-lived nuclides produced at IGISOL facility. Systematic uncertainties that impose limitations on the accuracy of measurements are discussed. It was found out that the phase evolution of the radial motion of ions in a Penning trap during the application of radio-frequency fields leads to a systematic cyclotron frequency shift when more than one ion species is present in the trap during the cyclotron frequency measurement. An analytic expression was derived to correctly account for the shift. Cross-reference mass…

Phase-Imaging Ion-Cyclotron-Resonance technique at the JYFLTRAP double Penning trap mass spectrometer

2018

The Phase-Imaging Ion-Cyclotron-Resonance (PI-ICR) technique has been commissioned at the JYFLTRAP double Penning trap mass spectrometer. This technique is based on projecting the ion motion in the Penning trap onto a position-sensitive multichannel-plate ion detector. Mass measurements of stable 85 Rb $ ^{+}$ and 87 Rb $ ^{+}$ ions with well-known mass values show that relative uncertainties $ \Delta m/m \leq 7\cdot 10^{-10}$ are possible to reach with the PI-ICR technique at JYFLTRAP. The significant improvement both in resolving power and in precision compared to the conventional Time-of-Flight Ion Cyclotron Resonance technique will enable measurements of close-lying isomeric states and …

High-resolution scattering experiments at the K130 cyclotron in Jyväskylä

2018

Abstract An experimental setup for nuclear reaction studies induced by light and heavy ions is described. It consists of a versatile Large Scattering Chamber equipped with two rotating tables for mounting detectors. A dedicated beam diagnostic system is used to monitor the energy spectrum of the beam on target. The system provides the necessary feedback for tuning of the K-130 cyclotron to reduce the energy spread of the accelerated beam by at least a factor of 3 down to about 0.3% of the nominal energy while maintaining beam currents around 20 pnA. At lower beam currents a 0.1% energy spread can be achieved. This improvement makes a significant impact on the scope of reaction studies possi…

Brief emotional eating scale : A multinational study of factor structure, validity, and invariance

2023

Emotional eating or the tendency to eat in response to emotional states can be assessed using self-report measures. The Emotional Eating Scale-II is a commonly used and reliable instrument that measures the desire to eat in response to a range of unpleasant and pleasant emotions. The current study aimed to corroborate the validity of the EES-II and expand its utility by investigating its dimensionality and testing its measurement invariance in samples from English-speaking and non-English-speaking countries. Convergent and predictive validity in respect of food craving, eating, and health indicators were also examined. This cross-national study included a total of 2485 adult participants re…

Introduction : Open Dialogue around the world – implementation, outcomes, experiences and perspectives

2023

“Open Dialogue behind locked doors” – exploring the experiences of patients, family members, and professionals with network meetings in a locked psyc…

2018

This paper explores and describes the experiences of patients, family members, and professionals with the Open Dialogue approach to network meetings at a locked psychiatric hospital unit in Norway. Previous research on Open Dialogue has mostly focused on acute crises in community care contexts. In this article, we discuss the participants’ experiences with Open Dialogue in a new context; that is in an inpatient locked unit. The inpatients are suffering from severe mental illness and might have been admitted to the unit against their will. The study has a qualitative design. Data were collected through a focus group interview with professionals and from written evaluations by patients and th…