Search results for "SYNAPTIC-PLASTICITY"
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Exogenous t-PA Administration Increases Hippocampal Mature BDNF Levels. Plasmin- or NMDA-Dependent Mechanism?
2014
International audience; Brain-derived neurotrophic factor (BDNF) through TrkB activation is central for brain functioning. Since the demonstration that plasmin is able to process pro-BDNF to mature BDNF and that these two forms have opposite effects on neuronal survival and plasticity, a particular attention has been paid to the link between tissue plasminogen activator (tPA)/plasmin system and BDNF metabolism. However, t-PA via its action on different N-methyl-D-aspartate (NMDA) receptor subunits is also considered as a neuromodulator of glutamatergic transmission. In this context, the aim of our study was to investigate the effect of recombinant (r)t-PA administration on brain BDNF metabo…
A MINIREVIEW ABOUT SPORTING PRACTICE IN EPILEPTIC CHILDREN
2017
Movement is important for neuropsycho-physical development, ensuring the correct growth and giving many benefits from childhood to adulthood. Motor activity plays a pivotal role in psychological, educational and social terms: sport practice induces harmonious physical development with common important benefits independently from sport type and each sport imposes rules respect that children learns to know and respect step by step improving the social skills and cognitive abilities. Sport has a very important role in the growth of children and adolescents. Sport and physical activity work as a moral laboratory to practice decision-making and problem-solving skills, as well as teamwork and coo…