Search results for "SYNDROME CORONAVIRUS"
showing 10 items of 552 documents
Systemic treatment of patients with solid tumors during the COVID-19 (SARS-CoV-2) pandemic : comprehensive recommendations of the Polish Society of C…
2020
Communication, Cohesion, and Corona: The Impact of People’s Use of Different Information Sources on their Sense of Societal Cohesion in Times of Cris…
2021
Solidarity among society is considered crucial to tackle the corona pandemic. With the crisis evoking a high need for orientation, the information people obtain from different sources may shape whe...
Unexpected tumor reduction in metastatic colorectal cancer patients during SARS-Cov-2 infection: effect of ACE-2 expression on tumor cells or molecul…
2021
Structure‐Activity Relationships of Benzamides and Isoindolines Designed as SARS‐CoV Protease Inhibitors Effective against SARS‐CoV‐2
2020
Abstract Inhibition of coronavirus (CoV)‐encoded papain‐like cysteine proteases (PLpro) represents an attractive strategy to treat infections by these important human pathogens. Herein we report on structure‐activity relationships (SAR) of the noncovalent active‐site directed inhibitor (R)‐5‐amino‐2‐methyl‐N‐(1‐(naphthalen‐1‐yl)ethyl) benzamide (2 b), which is known to bind into the S3 and S4 pockets of the SARS‐CoV PLpro. Moreover, we report the discovery of isoindolines as a new class of potent PLpro inhibitors. The studies also provide a deeper understanding of the binding modes of this inhibitor class. Importantly, the inhibitors were also confirmed to inhibit SARS‐CoV‐2 replication in …
Unreliable predictions about COVID‐19 infections and hospitalizations make people worry: The case of Italy
2021
The Role of Molecular Chaperones in Virus Infection and Implications for Understanding and Treating COVID-19
2020
The COVID-19 pandemic made imperative the search for means to end it, which requires a knowledge of the mechanisms underpinning the multiplication and spread of its cause, the coronavirus SARS-CoV-2. Many viruses use members of the hosts’ chaperoning system to infect the target cells, replicate, and spread, and here we present illustrative examples. Unfortunately, the role of chaperones in the SARS-CoV-2 cycle is still poorly understood. In this review, we examine the interactions of various coronaviruses during their infectious cycle with chaperones in search of information useful for future research on SARS-CoV-2. We also call attention to the possible role of molecular mimicry in the dev…
Does abdominal obesity influence immunological response to SARS-CoV-2 infection?
2021
Several hundred studies, 40 systematic reviews, and nearly 20 meta-analyses had been published by early 2021, confirming an increased need for medical services for people living with overweight or ...
Lead Discovery of SARS-CoV-2 Main Protease Inhibitors through Covalent Docking-Based Virtual Screening
2021
During almost all 2020, coronavirus disease 2019 (COVID-19) pandemic has constituted the major risk for the worldwide health and economy, propelling unprecedented efforts to discover drugs for its prevention and cure. At the end of the year, these efforts have culminated with the approval of vaccines by the American Food and Drug Administration (FDA) and the European Medicines Agency (EMA) giving new hope for the future. On the other hand, clinical data underscore the urgent need for effective drugs to treat COVID-19 patients. In this work, we embarked on a virtual screening campaign against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Mpro chymotrypsin-like cysteine pro…
From virtual to real healing: a critical overview of the therapeutic use of virtual reality to cope with mourning
2021
In recent years, virtual reality (VR) has been effectively employed in several settings, ranging from health care needs to leisure and gaming activities. A new application of virtual stimuli appeared in social media: in the documentary 'I met you' from the South-Korean Munhwa Broadcasting, a mother made the experience of interacting with the avatar of the seven-year-old daughter, who died four years before. We think that this new application of virtual stimuli should open a debate on its possible implications: it represents contents related to grief, a dramatic and yet natural experience, that can have deep psychological impacts on fragile subjects put in virtual environments. In the presen…
A Novel Heuristic Global Algorithm to Predict the COVID-19 Pandemic Trend
2020
SummaryMathematical models are useful tools to predict the course of an epidemic. A heuristic global Gaussian-function-based algorithm for predicting the COVID-19 pandemic trend is proposed for estimating how the temporal evolution of the pandemic develops by predicting daily COVID-19 deaths, for up to 10 days, starting with the day the prediction is made. The validity of the proposed heuristic global algorithm was tested in the case of China (at different temporal stages of the pandemic). The algorithm was used to obtain predictions in six different locations: California, New York, Iran, Sweden, the United Kingdom, and the entire United States, and in all cases the prediction was confirmed…