Search results for "Sack"
showing 5 items of 55 documents
Onychomadesis Outbreak in Valencia, Spain Associated with Hand, Foot, and Mouth Disease Caused by Enteroviruses
2011
This report evaluates the June 2008 onychomadesis outbreak in Valencia, Spain. The study sample consisted of 221 onychomadesis cases and 77 nonaffected individuals who lived close to those affected. We collected data on dietary variables, hygiene products, and individual pathological histories. Feces and blood specimens were collected from 44 cases and 24 controls to evaluate exposure to infectious agents. Pathological background data revealed a high frequency (61%) of hand, foot, and mouth disease among the onychomadesis cases. Coxsackievirus A10 was the most commonly detected enterovirus in both case and control groups (49%). Other enteroviruses such as coxsackieviruses A5, A6, A16, B1, a…
"Na Ukrainie za owych dobrych czasów" - "Przed laty. Powieść ukraińska" Paulina Święcickiego
2020
The forgotten work and life of Paulin Święcicki (1841–1876), a writer from Kiev region and active in Galicia, represents a rare, authentic example of Polish‑Ukrainian cultural border. His debut work entitled Przed laty. Powieść ukraińska (1865), despite being an artistic failure, is an interesting link between the heritage of the Romantic “Ukrainian School” and the historical vision of Polish Borderlands in With fire and sword by Henryk Sienkiewicz. The creation of the 17th‑century reality of Ukrainian grasslands (noble, rural and Cossack existence), battle scenes (fights against the Tatars), romantic‑melodramatic plot – these are all adapted to a unique Ukrainian (not Polish‑centred) persp…
The activation of aggresomal pathway in Coxsackievirus B3 infection
2016
Aggresomin muodostuminen on yksi solun puolustusmekanismeista, joka pyrkii estämään proteiinien haitallisen aggregoitumisen solulimassa. Aikaisemmat kokeet ovat näyttäneet, että ihmisen enterovirus-infektio aiheuttaa muutoksia vimentiinissä, tyypin III välikokoisessa filamentissa (Turkki et al., julkaisematon data). Nämä muutokset ovat hyvin samankaltaisia aggresomin muodostumisen aikana tapahtuvien muutoksien kanssa. Tämän tutkimuksen tarkoituksena oli selvittää mahdollisen aggresomin muodostumisreitin aktivoituminen Coxsackievirus B3 (CVB3) -infektiossa, ja hypoteesimme oli, että häkkimäisten vimentiinirakenteiden muodostumisen lisäksi myös muita aggresomin muodostumisreitin aktivoitumise…
CVB3 VP1 interacts with MAT1 to inhibit cell proliferation by interfering with Cdk-activating kinase complex activity in CVB3-induced acute pancreati…
2021
Coxsackievirus B3 (CVB3) belongs to the genus Enterovirus of the family Picornaviridae and can cause acute acinar pancreatitis in adults. However, the molecular mechanisms of pathogenesis underlying CVB3-induced acute pancreatitis have remained unclear. In this study, we discovered that CVB3 capsid protein VP1 inhibited pancreatic cell proliferation and exerted strong cytopathic effects on HPAC cells. Through yeast two-hybrid, co-immunoprecipitation, and confocal microscopy, we show that Menage a trois 1 (MAT1), a subunit of the Cdk-Activating Kinase (CAK) complex involved in cell proliferation and transcription, is a novel interaction protein with CVB3 VP1. Moreover, CVB3 VP1 inhibited MAT…
The Jews in Times of Warand the Social and Political Riots in the Southeast of the Polish-Lithuanian Commonwealth in the 17th and 18th Centuries Cont…
2014
W wiekach XVII i XVIII na południowo-wschodnich terenach Rzeczypospolitej znajdowało się największe na świecie, dynamicznie rozwijające się skupisko ludności żydowskiej. Korzystne warunki zamieszkania zapewniały Żydom przywileje prawne i ekonomiczne oraz opiekę ze strony właścicieli wielkich majątków ziemskich. Egzystencja skupisk ludności wyznania mojżeszowego w stosunkowo niewielkim stopniu była zakłócana przez antyżydowskie działania władz kościelnych, procesy o mordy rytualne oraz wrogość ludności rodzimej (Rusinów). W początkowym okresie powstania Chmielnickiego doszło do wielkiego pogromu Żydów na Ukrainie, Podolu i Wołyniu. Jednak już w latach 60. XVII w. gminy żydowskie na tych tere…