Search results for "Salvia"

Cytotoxicity ofSalvia miltiorrhizaAgainst Multidrug-Resistant Cancer Cells

2016

Salvia miltiorrhiza Bunge (Lamiaceae) is a well-known Chinese herb that possesses numerous therapeutic activities, including anticancer effects. In this study, the cytotoxicity and the biological mechanisms of S. miltiorrhiza (SM) root extract on diverse resistant and sensitive cancer cell lines were investigated. CEM/ADR5000 cells were 1.68-fold resistant to CCRF-CEM cells, while HCT116 (p53[Formula: see text] and U87.MG[Formula: see text]EGFR cells were hypersensitive (collateral sensitive) compared to their parental cells. SM root extract stimulated ROS generation, cell cycle S phase arrest and apoptosis. The induction of the intrinsic apoptotic pathway was validated by increased cleavag…

Pharmacogenomic Characterization of Cytotoxic Compounds from Salvia officinalis in Cancer Cells.

2015

Salvia officinalis is used as a dietary supplement with diverse medicinal activity (e.g. antidiabetic and antiatherosclerotic effects). The plant also exerts profound cytotoxicity toward cancer cells. Here, we investigated possible modes of action to explain its activity toward drug-resistant tumor cells. Log10IC50 values of two constituents of S. officinalis (ursolic acid, pomolic acid) were correlated to the expression of ATP-binding cassette (ABC) transporters (P-glycoprotein/ABCB1/MDR1, MRP1/ABCC1, BCRP/ABCG2) and epidermal growth factor receptor (EGFR) or mutations in RAS oncogenes and the tumor suppressor gene TP53 of the NCI panel of cell lines. Gene expression profiles predicting se…

Synthetic studies of neoclerodane diterpenoids from Salvia splendens and evaluation of opioid receptor affinity

2008

Abstract Salvinorin A ( 1 ), a neoclerodane diterpene from the hallucinogenic mint Salvia divinorum , is the only known non-nitrogenous and specific κ-opioid agonist. Several structural congeners of 1 isolated from Salvia splendens ( 2 – 8 ) together with a series of semisynthetic derivatives ( 9 – 24 ), some of which possess a pyrazoline structural moiety ( 9 , 19 – 22 ), have been tested for affinity at human μ, δ, and κ opioid receptors. None of these compounds showed high affinity binding to these receptors. However, 10 showed modest affinity for κ receptors suggesting that other natural neoclerodanes from different Salvia species may possess opioid affinity.

Metabolites from Mediterranean plants: characterization and transformation. Chemotaxonomic assessment and biological activity.

Questo progetto di ricerca ha lo scopo di ampliare le conoscenze di alcune piante appartenenti alla flora Mediterranea. Le piante da studiare sono state scelte in seguito ad un’attenta analisi bibliografica tra specie poco sudiate. La scelta è quindi ricaduta su nove specie appartenenti al genere Anthemis, due specie appartenenti al genere Pulicaria e sulle specie di Tetraclinis articulata, Salvia argentea, Ajuga tenorei, Ballota hispanica, Moluccella Spinosa e Thapsia garganica. Di esse sono stati preparati ed identificati i componenti degli oli essenziali e successivamente effettuati su di essi i saggi antibatterici. Dagli estratti delle specie di Tetraclinis articulata e Ajuga tenorei so…

The «Painted» Hypogeum of Crispia Salvia (Marsala-TP) ‒ 2nd Century C.E. Preliminary Anthropological and Archaeological Report of Tomb 3 and Tomb 4

2021

Summary ― The «Painted Hypogeum of Crispia Salvia» is the most important monument of the ancient Punic-Roman necropolis of Lilibeo (today's Marsala). It is the only known paradigmatic example in Sicily of pictorial wall decoration. Iulius Demetrius commissioned the monument in memory of his wife Crispia Salvia, a noblewoman descended from two very important Sicilian families. Here we report on a preliminary anthropological study of Tombs 3 and 4 (Crispia Salvia and Iulius Demetrius). We integrated the historical-cultural context with the osteological data. The results combining laboratory and archaeological research confirm the presence of two high-ranking individuals characterized by condi…

Chemical composition and anticancer activity of essential oil of Mediterranean sage (Salvia officinalis L.)

2013

Considerazioni sulle strutture edilizie dell'area del Tempio-Criptoportico

2013

Il contributo si prefigge lo scopo di analizzare le emergenze architettoniche dell'area del Tempio-Criptoportico, centro cultuale della città romana di Urbs Salvia. Il grande complesso sntuariale venen eretto in età tiberiano-claudia al di sopra di un quartiere abitativo di notevole pregio che si affacciava sul lato orientale del Foro della città. Un poderoso Criptoportico fungeva da sostegno ad un Tempio esastilo corinzio, del quale oggi restano solo scarni resti del podio, circondato da un portico su tre lati. Lo studio propone una ipotesi ricostruttiva del complesso e delle sue fasi di vita.

Complete 1H and 13C NMR assignments of clerodane diterpenoids of Salvia splendens.

2006

Unambiguous and complete assignments of 1H and 13C NMR chemical shifts for five clerodane diterpenes, four of them isolated from Salvia splendens (salviarin, splendidin and splenolides A and B) and one obtained by acetylation of splenolide A, are presented. The assignments are based on 2D shift-correlated [1H,1H–COSY, 1H,13C-gHSQC–1J(C,H) and 1H,13C-gHMBC-nJ(C,H) (n = 2 and 3)] and nuclear Overhauser effect (NOE) experiments. The conformation of the rings of these compounds is supported by the 3J(H,H) values and NOE results. Copyright © 2006 John Wiley & Sons, Ltd.

Essential oils of Salvia bracteata and Salvia rubifolia from Lebanon: Chemical composition, antimicrobial activity and inhibitory effect on human mel…

2009

Aim of the study: Salvia bracteata Banks et Sol. and Salvia rubifolia Boiss. are known in folk medicine of Lebanon for the treatment of microbial infections, cancer, urinary and pulmonary problems. In the present study the chemical composition and antimicrobial activity of essential oils from aerial parts of Salvia bracteata and Salvia rubifolia collected in Lebanon were evaluated. The oils were also tested for their potential antiproliferative effects against M14 human melanoma cells. Material and methods: The oils were studied by GC and GC-MS and their antibacterial activity (MIC and MBC) was tested against ten bacteria species using the broth dilution method. The inhibitory effect on hum…

Towards a new classification of Salvia s.l.: (re)establishing the genus Pleudia Raf.

2015

Salvia L. In its traditional circumscription is the largest genus within the mint family. To date, the magnitude of the task has rendered it difficult to provide a genus-wide revision based on morphological data. Current molecular investigations based on a dense taxon sampling representing the whole phenotypic diversity and distribution range of Salvia confirmed that the genus is polyphyletic. Salvia species fall in 4 distinct clades, although all of them, except Clade IV, also include non-Salvia genera. A taxonomic revision is thus urgently needed with two different approaches that have to be considered: (1) to include the 5 morphologically distinct non-Salvia genera in Salvia or (2) to sp…