Search results for "Sample"
showing 10 items of 2270 documents
Placebo Therapy in Crohn's disease
2009
The knowledge of the outcome among patients receiving placebo is important for evaluating the response to therapy, for evaluating the natural history of a disease and for calculating the sample size for future clinical trials. In Crohn's disease placebo has been used in therapeutic trials in every relevant setting: active disease, prevention of relapse after induced medical remission and after surgery and fistulising disease. The analysis of the placebo response shows that in every setting there is a high heterogeneity demonstrating mainly that the selection of patients is not often homogeneous and that the outcome criteria used in the trials is not highly reliable. Better selection of pati…
From Sample to Section
1998
A sound analysis of microstructures relies on correct sampling and on the right choice of the direction in which thin sections are cut from samples. This chapter discusses the steps of sample collection; choice of sectioning plane, and problems involved in the interpretation of three-dimensional structures from two-dimensional sections.
Fast multi-directional DSLM for confocal detection without striping artifacts
2020
In recent years light-sheet fluorescence microscopy (LSFM) has become a cornerstone technology for neuroscience, improving the quality and capabilities of 3D imaging. By selectively illuminating a single plane, it provides intrinsic optical sectioning and fast image recording, while minimizing out of focus fluorescence background, sample photo-damage and photo-bleaching. However, images acquired with LSFM are often affected by light absorption or scattering effects, leading to un-even illumination and striping artifacts. In this work we present an optical solution to this problem, via fast multi-directional illumination of the sample, based on an acousto-optical deflector (AOD). We demonstr…
Children’s Feeling of Security
2021
This chapter outlines the authors’ work as a research team participating in CUWB (Children’s Understanding of Well Being) since it was first created, based on a project registered with the CICS-UP, School of Social Sciences of the Universidad de Palermo, Argentina. The chapter focuses on a key aspect of their findings: children’s feelings of security. The general objective of the project is to understand the social, cultural and political dimensions of the life experiences of children living in different geographic contexts in the Buenos Aires Region, Argentina, taking account of the children’s own words. This is a qualitative study that recognizes the importance of the contexts and the mea…
Estimating pollutant emissions based on speed profiles at urban roundabouts: A pilot study
2019
The paper describes the pilot study conducted to assess the feasibility of the empirical approach utilizing vehicle trajectory data from a smartphone app and the Vehicle-Specific Power methodology to estimate pollutant emissions at urban roundabouts. The goal of this research phase is to acquire instantaneous speed data from a sample of six roundabouts located in the road network of the City of Palermo, Italy, and quantify emissions generated by the test vehicle through the examined roundabouts. For the case studies of roundabouts acceleration events in the circulating and exiting areas contributed to about 25% of the emissions for a given speed profile. More in general, the results from th…
Analytical challenges to determine emerging persistent organic pollutants in aquatic ecosystems
2018
Emerging persistent organic pollutants (ePOPs) include polybrominated diphenyl ethers (PBDEs) and perfluorooctane sulfonyl fluoride/perfluorooctane sulfonate (POSF/PFOS), which are newly listed in the Stockholm Convention. Other ePOPs, which have not been regulated, include organophosphate flame retardants (PFRs), novel brominated flame retardants (NBFRs) and other perfluoroalkyl substances (PFASs). Often ePOPs data related to occurrence, toxicity, impact or environmental behavior are insufficient or inadequate because of the lack of proper analytical methods to obtain them. Thus, a critical review of the analytical procedures proposed in the last six years (2011–2017) for determining ePOPs…
Eco-efficiency assessment of wastewater treatment plants using a weighted Russell directional distance model
2016
Abstract Improving the performance of wastewater treatment plants is essential to ensuring their long-term sustainability. Most of the previous studies on this topic have assessed the techno-economic efficiency of wastewater treatment plants and ignored the emission of greenhouse gases. For the first time, the weighted Russell directional distance model was applied to estimate the eco-efficiency of a sample of real wastewater treatment plants. Moreover, this approach allowed an inefficiency score to be obtained for each variable (cost factors, pollutant removal and greenhouse gases) involved in the model. Subsequently, a second stage of analysis was applied to identify factors influencing t…
Measuring the wastewater treatment plants productivity change: Comparison of the Luenberger and Luenberger-Hicks-Moorsteen Productivity Indicators
2019
Abstract It is essential to assess the productivity of wastewater treatment plants (WWTPs) to improve their economic and technical performance over time. In doing so, reliable indexes should be used to avoid biased conclusions leading to unsuccessful policy and managerial measures. Ratio-based indexes are typically employed, but are infeasible when any of the variables are equal or close to zero. To overcome this limitation, this paper presents the innovative approach of applying and comparing two difference-based productivity indicators, Luenberger (LPI) and Luenberger-Hicks-Moorsteen (LHMPI), to evaluate how productivity changes in a sample of WWTPs. Because the LHMPI is an additively com…
Analysing the efficiency of wastewater treatment plants: The problem of the definition of desirable outputs and its solution
2020
Abstract Evaluating the efficiency of wastewater treatment plants (WWTPs) is highly relevant to improve their performance from an economic and environmental perspective. The issue is even more critical in countries where WWTPs are benchmarked to regulate water companies and define WWTPs’ economic and environmental objectives. Despite the large number of previous studies on this topic, none has considered that the amount of outputs produced by the WWTPs is restricted by the concentration of pollutants in the effluent. To overcome this limitation, the study’s main objective was to propose a new variant of the Weighted Russell Directional Distance Model (WRDDM) that would solve problems regard…
Application potential of dummy molecularly imprinted polymers as solid-phase extraction sorbents for determination of low-mass polybrominated dipheny…
2019
Abstract Despite the introduction of restrictive regulations in the USA and the European Union, polybrominated diphenyl ethers (PBDEs) are still found in various types of environmental and biological samples at significant concentration levels. The presence of these persistent organic pollutants in the environment raises important issues because of their negative impact on immunological and neurological systems, and on the hormonal balances in living organisms. From the analytical point of view, the final determination of PBDEs would entail substantial challenges, because it would necessitate conducting the pre-concentration of analytes, or sample clean up. The aim of the present study is t…