Search results for "Sarcopenia"
showing 9 items of 159 documents
Role of muscle-targeted nutritional therapy: new data.
2022
Purpose of review To provide an updated overview of recent efficacy data on the use of muscle-targeted nutritional therapy, which should consider the optimization of protein and essential amino acids intakes, possibly in combination with supplementation with vitamin D (correction of deficiency/insufficiency status) and v-3 fatty acids. Recent findings Intervention studies conducted in the last years in different healthcare settings and heterogeneous patient populations support the use of muscle-targeted oral nutritional supplementation to improve muscle mass, function and physical performance in patients with sarcopenia. Higher efficacy is likely to be achieved in combination with individua…
Treatment of sarcopenia by targeting Akt and muscle specific ubiquitin ligases. Evidence from mice and from a clinical trial
2017
Disuse muscle wasting may take place as a result of several such as joint immobilization, inactivity or bed rest. There are no good therapies to treat it. Allopurinol, a drug commonly used to treat hyperuricemia and gout, protects muscle damage, specially after exhaustive exercise and results in functional gains in old persons. Thus, we tested its effect in the prevention of atrophy of the soleus muscle after two weeks of hindlimb unloading in experimental animals (mice), and lower leg immobilization following ankle sprain in humans (Registration of the clinical Trial: EUDRACT2011-003541-17). We have found show that allopurinol protects against muscle atrophy in both mice and humans. The pr…
Sarcopenia, sarcopenic obesity and insulin-resistance
2011
Sarcopenia: Research and Clinical Implications
2021
This book offers a concise and updated guide for all readers (physicians and non-physicians) interested in gaining a comprehensive and precise understanding of sarcopenia. Over the last several years, sarcopenia has increasingly developed from being a concept known only in research settings to one that is commonly explored in journals and scientific meetings for various disciplines, such as geriatrics, rheumatology and rehabilitation medicine. Thus, all domains of sarcopenia, from molecular aspects to clinical management, represent highly active areas of research and clinical practice for health professionals in a variety of fields, including geriatric medicine, nutrition, and epidemiology.…
Efectos de un programa de fuerza de alta intensidad de 6 meses de duración sobre parámetros funcionales, clínicos y biomarcadores de imagen en mujere…
2022
Introducción: La sarcopenia se caracteriza por la pérdida de masa, fuerza y funcionalidad de la musculatura en los adultos mayores. La realización de ejercicio físico, y en concreto, el entrenamiento de fuerza, se recomienda para la prevención y manejo de la sarcopenia, pero se desconoce si comporta un beneficio a nivel de calidad y cantidad de la masa muscular según parámetros de imagen por resonancia magnética (IRM). Actualmente, el diagnóstico de sarcopenia está limitado por la falta de consenso en su definición y la heterogeneidad de herramientas que se usan en su análisis. Los criterios diagnósticos deberían incluir, además de una evaluación clínica, unos marcadores objetivos con el fi…
Age and Muscle Function Are More Closely Associated With Intracellular Magnesium, as Assessed by
2019
Total serum magnesium is a common clinical measurement for assessing magnesium status; however, magnesium in blood represents less than 1% of the body’s total magnesium content. We measured intramuscular ionized magnesium by phosphorus magnetic resonance spectroscopy (31P-MRS) and tested the hypothesis that this measure better correlates with skeletal muscle function and captures more closely the effect of aging than the traditional measure of total serum magnesium. Data were collected from 441 participants (age 24–98 years) in the Baltimore Longitudinal Study of Aging (BLSA), a study of normative aging that encompasses a broad age range. Results showed that intramuscular ionized magnesium …
Diagnóstico de sarcopenia y medición de la composición corporal en pacientes con cáncer mediante tomografía computarizada
2020
Los pacientes con cáncer presentan desnutrición asociada no sólo con las características propias del tumor, sino también a los tratamientos que deben ser aplicados para la curación de la enfermedad (cirugía, quimioterapia o radioterapia). El cáncer tiene un efecto negativo sobre la composición corporal, ya que disminuye directamente la ingesta de alimentos del paciente (interfiere mecánicamente con el tránsito del aparato digestivo), o indirectamente (a través de la secreción de sustancias que actúan sobre los receptores periféricos o el hipotálamo). Asimismo, los diferentes tipos de tratamientos aplicados en pacientes con cáncer son una causa importante de la alteración de su estado nutric…
Role of Menopausal Transition and Physical Activity in Loss of Lean and Muscle Mass : A Follow-Up Study in Middle-Aged Finnish Women
2020
In midlife, women experience hormonal changes due to menopausal transition. A decrease especially in estradiol has been hypothesized to cause loss of muscle mass. This study investigated the effect of menopausal transition on changes in lean and muscle mass, from the total body to the muscle fiber level, among 47–55-year-old women. Data were used from the Estrogenic Regulation of Muscle Apoptosis (ERMA) study, where 234 women were followed from perimenopause to early postmenopause. Hormone levels (estradiol and follicle stimulating hormone), total and regional body composition (dual-energy X-ray absorptiometry (DXA) and computed tomography (CT) scans), physical activity level (self-reported…
Estudio de la sarcopenia y la fragilidad en una población diabética de edad avanzada y su relación con parámetros de estrés oxidativo
2022
El envejecimiento de la población ha provocado que enfermedades crónicas asociadas a la edad como la diabetes mellitus tipo 2 (DM2) y síndromes geriátricos como la fragilidad o la sarcopenia hayan aumentado su prevalencia en la población. La DM2 aumenta el riesgo de padecer sarcopenia y fragilidad en la población geriátrica a la vez que el diagnóstico de sarcopenia y fragilidad supone un factor de riesgo para el desarrollo de diabetes. Al estudiar los mecanismos fisiopatológicos de estas patologías se encuentra el estrés oxidativo (EO) como unión, que podría explicar parte de las consecuencias clínicas asociadas tanto a la fragilidad y sarcopenia como a la DM2. Nuestro objetivo fue estudiar…